AS3MT

AS3MT
Pengidentifikasi
Alias	AS3MT, CYT19, arsenite methyltransferase
ID Eksternal	OMIM: 611806; MGI: 1929882; HomoloGene: 10754; GeneCards: AS3MT; OMA:AS3MT - orthologs
Nomor EC	2.1.1.137
Pola ekspresi RNA
	Ekspresi tertinggi di
	right adrenal gland; ; right adrenal cortex; ; left adrenal cortex; ; right lobe of liver; ; apex of heart; ; left ventricle; ; ganglionic eminence; ; ventricular zone; ; right auricle of heart; ; limpa;
	Ekspresi tertinggi di
	Kantung kuning telur; ; right kidney; ; soleus muscle; ; Tubulus proksimal; ; interventricular septum; ; median eminence; ; arcuate nucleus; ; myocardium of ventricle; ; neural layer of retina; ; Paneth cell;
	Referensi data ekspresi selengkapnya
	n/a
Ontologi gen
Fungsi molekuler	methyltransferase activity; transferase activity; methylarsonite methyltransferase activity; arsenite methyltransferase activity;
Komponen seluler	sitosol; sitoplasma;
Proses biologis	toxin metabolic process; arsonoacetate metabolic process; Metilasi;
	Sumber:Amigo / QuickGO
Ortologi
	57412
	57344
	ENSG00000214435
	ENSMUSG00000003559
	Q9HBK9
	Q91WU5
	NM_020682
	NM_020577
	NP_065733
	NP_065602
	Wikidata
Lihat/Sunting Manusia	Lihat/Sunting Tikus

Arsenite methyltransferase adalah enzim yang pada manusia disandi oleh gen AS3MT.^[3]^[4]

Referensi

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lin S, Shi Q, Nix FB, Styblo M, Beck MA, Herbin-Davis KM, Hall LL, Simeonsson JB, Thomas DJ (March 2002). "A novel S-adenosyl-L-methionine:arsenic(III) methyltransferase from rat liver cytosol". The Journal of Biological Chemistry. 277 (13): 10795–803. doi:10.1074/jbc.M110246200. PMID 11790780.
^ "Entrez Gene: AS3MT arsenic (+3 oxidation state) methyltransferase".

Bacaan lebih lanjut

Dheeman DS, Packianathan C, Pillai JK, Rosen BP (November 2014). "Pathway of human AS3MT arsenic methylation". Chemical Research in Toxicology. 27 (11): 1979–89. doi:10.1021/tx500313k. PMC 4237493. PMID 25325836.
Hernández A, Xamena N, Sekaran C, Tokunaga H, Sampayo-Reyes A, Quinteros D, Creus A, Marcos R (April 2008). "High arsenic metabolic efficiency in AS3MT287Thr allele carriers". Pharmacogenetics and Genomics. 18 (4): 349–55. doi:10.1097/FPC.0b013e3282f7f46b. PMID 18334919. S2CID 25842224.
Fujihara J, Kunito T, Agusa T, Yasuda T, Iida R, Fujii Y, Takeshita H (December 2007). "Population differences in the human arsenic (+3 oxidation state) methyltransferase (AS3MT) gene polymorphism detected by using genotyping method". Toxicology and Applied Pharmacology. 225 (3): 251–4. Bibcode:2007ToxAP.225..251F. doi:10.1016/j.taap.2007.08.010. PMID 17889916.
Hernández A, Xamena N, Surrallés J, Sekaran C, Tokunaga H, Quinteros D, Creus A, Marcos R (January 2008). "Role of the Met(287)Thr polymorphism in the AS3MT gene on the metabolic arsenic profile". Mutation Research. 637 (1–2): 80–92. doi:10.1016/j.mrfmmm.2007.07.004. PMID 17850829.
Lindberg AL, Kumar R, Goessler W, Thirumaran R, Gurzau E, Koppova K, Rudnai P, Leonardi G, Fletcher T, Vahter M (July 2007). "Metabolism of low-dose inorganic arsenic in a central European population: influence of sex and genetic polymorphisms". Environmental Health Perspectives. 115 (7): 1081–6. Bibcode:2007EnvHP.115.1081L. doi:10.1289/ehp.10026. PMC 1913583. PMID 17637926.
Schläwicke Engström K, Broberg K, Concha G, Nermell B, Warholm M, Vahter M (April 2007). "Genetic polymorphisms influencing arsenic metabolism: evidence from Argentina". Environmental Health Perspectives. 115 (4): 599–605. Bibcode:2007EnvHP.115..599E. doi:10.1289/ehp.9734. PMC 1852682. PMID 17450230.
Meza M, Gandolfi AJ, Klimecki WT (August 2007). "Developmental and genetic modulation of arsenic biotransformation: a gene by environment interaction?". Toxicology and Applied Pharmacology. 222 (3): 381–7. Bibcode:2007ToxAP.222..381M. doi:10.1016/j.taap.2006.12.018. PMC 2040165. PMID 17306849.
Wood TC, Salavagionne OE, Mukherjee B, Wang L, Klumpp AF, Thomae BA, Eckloff BW, Schaid DJ, Wieben ED, Weinshilboum RM (March 2006). "Human arsenic methyltransferase (AS3MT) pharmacogenetics: gene resequencing and functional genomics studies". The Journal of Biological Chemistry. 281 (11): 7364–73. doi:10.1074/jbc.M512227200. PMID 16407288.
Meza MM, Yu L, Rodriguez YY, Guild M, Thompson D, Gandolfi AJ, Klimecki WT (June 2005). "Developmentally restricted genetic determinants of human arsenic metabolism: association between urinary methylated arsenic and CYT19 polymorphisms in children". Environmental Health Perspectives. 113 (6): 775–81. Bibcode:2005EnvHP.113..775M. doi:10.1289/ehp.7780. PMC 1257606. PMID 15929903.
Li J, Waters SB, Drobna Z, Devesa V, Styblo M, Thomas DJ (April 2005). "Arsenic (+3 oxidation state) methyltransferase and the inorganic arsenic methylation phenotype". Toxicology and Applied Pharmacology. 204 (2): 164–9. Bibcode:2005ToxAP.204..164L. doi:10.1016/j.taap.2004.12.002. PMID 15808521.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.