Akuaporin 2

AQP2
Struktur yang tersedia
PDB	Pencarian Ortolog: PDBe RCSB
Daftar kode id PDB
	4OJ2, 4NEF
Pengidentifikasi
Alias	AQP2, AQP-CD, WCH-CD, aquaporin 2, NDI2
ID eksternal	OMIM: 107777 MGI: 1096865 HomoloGene: 20137 GeneCards: AQP2
Lokasi gen (Tikus)
Kr.	Kromosom 15 (tikus)
Akhir	99,482,428 bp
Pola ekspresi RNA
	Referensi data ekspresi selengkapnya
Ontologi gen
Fungsi molekuler	• aktivitas transporter; • aktivitas transporter transmembran gliserol; • aktivitas transporter transmembran air; • aktivitas saluran air; • GO:0001948, GO:0016582 Ikatan protein plasma; • aktivitas saluran;
Komponen seluler	• komponen integral membran; • recycling endosome; • badan Golgi; • membran; • Membran sel; • transport vesicle membrane; • membran plasma basolateral; • membran plasma apikal; • extracellular exosome; • cytoplasmic vesicle membrane; • GO:0016023 cytoplasmic vesicle; • integral component of plasma membrane; • lumenal side of membrane;
Proses biologis	• cellular response to mercury ion; • Ekskresi; • transpor air; • ion transmembrane transport; • renal water transport; • renal water homeostasis; • cellular response to copper ion; • metanephric collecting duct development; • cellular response to water deprivation; • glycerol transport; • GO:0015915 transpor; • transpor transmembran; • protein homotetramerization;
	Sumber:Amigo / QuickGO
Ortolog
	359
	11827
	ENSG00000167580
	ENSMUSG00000023013
	P41181
	P56402
	NM_000486
	NM_009699
	NP_000477
	NP_033829
	Wikidata
Lihat/Sunting Manusia	Lihat/Sunting Tikus

AQP2 ditemukan pada membran sel apikal sel utama duktus koligentes ginjal dan vesikel intraseluler yang terletak di seluruh sel.

Regulasi

Akuaporin 2 merupakan satu-satunya akuaporin yang diregulasi oleh vasopresin.^[4] Fungsi dasar akuaporin 2 adalah untuk mereabsorbsi air dari urin ketika air tersebut dibuang dari darah oleh ginjal. Akuaporin 2 ditemukan pada sel epitel ginjal dan biasanya dorman di dalam membran vesikel intraseluler. Ketika dibutuhkan, vasopresin berikatan dengan reseptor vasopresin permukaan sel yang mengaktifkan jalur pensinyalan dan menyebabkan vesikel yang memuat akuaporin 2 untuk berfusi dengan membran plasma sehingga akuaporin 2 dapat digunakan oleh sel.^[5]

Akuaporin ini diregulasi dengan dua cara oleh hormon peptida vasopresin, yaitu:

Regulasi jangka pendek (menit) melalui lalu lintas vesikel AQP2 ke wilayah apikal yang kemudian berfusi dengan membran plasma apikal.
Regulasi jangka panjang (hari) melalui peningkatan ekspresi gen AQP2.

Akuaporin ini juga diregulasi oleh asupan makanan. Berpuasa mengurangi ekspresi akuaporin ini yang tak bergantung vasopresin.

Signifikansi klinis

Mutasi saluran ini diasosiasikan dengan diabetes insipidus nefrogenik, yang dapat berupa dominan atau resesif autosomal. Mutasi pada reseptor vasopresin menyebabkan fenotipe terpaut-X serupa.

Litium, sering digunakan untuk mengobati gangguan bipolar, dapat menyebabkan diabetes insipidus perolehan (ditandai dengan ekskresi urin encer bervolume besar) dengan menurunkan ekspresi gen AQP2.

Ekspresi gen AQP2 meningkat dalam kondisi yang berkaitan dengan retensi air, seperti kehamilan dan gagal jantung kongestif.

Lihat juga

Akuaporin

Referensi

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023013 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dibas AI, Mia AJ, Yorio T (Desember 1998). "Aquaporins (water channels): role in vasopressin-activated water transport". Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine. 219 (3): 183–99. doi:10.3181/00379727-219-44332. PMID 9824541.
^ Lodish H, Berk A, Kaiser CA, Krieger M, Scott MP, Bretscher A, Ploegh H, Matsudaira P (2008). Molecular Cell Biology (edisi ke-6th). New York: Freeman. hlm. 445. ISBN 978-0-7167-7601-7.

Bacaan lanjutan

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Pranala luar

GeneReviews/NCBI/NIH/UW entri Diabetes Insipidus Nefrogenik
MeSH Aquaporin+2
Lokasi genom AQP2 manusia dan halaman rincian gen AQP2 dalam UCSC Genome Browser.

Artikel bertopik biokimia ini adalah sebuah rintisan. Anda dapat membantu Wikipedia dengan mengembangkannya.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000023013 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9824541-4] Dibas AI, Mia AJ, Yorio T (Desember 1998). "Aquaporins (water channels): role in vasopressin-activated water transport". Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine. 219 (3): 183–99. doi:10.3181/00379727-219-44332. PMID 9824541.

[5] Lodish H, Berk A, Kaiser CA, Krieger M, Scott MP, Bretscher A, Ploegh H, Matsudaira P (2008). Molecular Cell Biology (edisi ke-6th). New York: Freeman. hlm. 445. ISBN 978-0-7167-7601-7.

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