CD59
CD59 glikoprotein, juga dikenal sebagai MAC-inhibitory protein (MAC-IP), membrane inhibitor of reactive lysis (MIRL), atau protectin, adalah protein yang pada manusia dikodekan oleh gen CD59.[1] CD59 mengandung domain LU dan bagian dari keluarga protein LY6/uPAR/alpha-neurotoxin.[2]
CD59 menempel pada sel inang melalui jangkar glikofosfatidlinositol (GPI). Aktivasi komplemen menyebabkan deposisi C5b678 pada sel inang, tetapi CD59 dapat mencegah polimerisasi C9, sehingga mengahambat pembentukan kompleks serangan membran (MAC).[3]
Mutasi yang memengaruhi GPI sehingga mengurangi ekspresi CD59 dan DAF pada sel darah merah mengakibatkan hemoglobinuria nokturnal paroksismal.[4]
Virus seperti HIV, human cytomegalovirus dan vaccinia memasukkan CD59 sel inang ke dalam selubung virusnya sendiri untuk mencegah lisis oleh komplemen.[5]
Referensi
- ^ "Entrez Gene: CD59 molecule, complement regulatory protein".
- ^ Maio M, Brasoveanu LI, Coral S, Sigalotti L, Lamaj E, Gasparollo A, Visintin A, Altomonte M, Fonsatti E (Aug 1998). "Structure, distribution, and functional role of protectin (CD59) in complement-susceptibility and in immunotherapy of human malignancies (Review)". International Journal of Oncology. 13 (2): 305–18. doi:10.3892/ijo.13.2.305. PMID 9664126.
- ^ Huang Y, Qiao F, Abagyan R, Hazard S, Tomlinson S (September 2006). "Defining the CD59-C9 binding interaction". J. Biol. Chem. 281 (37): 27398–27404. doi:10.1074/jbc.M603690200. PMID 16844690. Pemeliharaan CS1: DOI bebas tanpa ditandai (link)
- ^ Parker C, Omine M, Richards S (2005). "Diagnosis and management of paroxysmal nocturnal hemoglobinuria". Blood. 106 (12): 3699–709. doi:10.1182/blood-2005-04-1717. PMC 1895106. PMID 16051736.
- ^ Bohana-Kashtan O, Ziporen L, Donin N, Kraus S, Fishelson Z (July 2004). "Cell signals transduced by complement". Mol. Immunol. 41 (6–7): 583–597. doi:10.1016/j.molimm.2004.04.007. PMID 15219997.
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