Cas2
| CRISPR-associated protein 2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Streptococcus pyogenes Cas2. PDB: 4QR2 | |||||||||
| Identifikasi | |||||||||
| Simbol | cas2 | ||||||||
| Pfam | PF09827 | ||||||||
| InterPro | IPR019199 | ||||||||
| |||||||||
Cas2 adalah protein yang terkait dengan CRISPR yang terlibat dalam perolehan spacer. Protein Cas2 yang representatif telah dikarakterisasi sebagai endonuklease yang memotong RNA untai tunggal secara preferensial di dalam wilayah kaya U,[1] atau sebagai endonuklease yang bergantung pada logam yang menargetkan DNA untai ganda (dsDNA).[2]
Referensi
- ^ Beloglazova N, Brown G, Zimmerman MD, Proudfoot M, Makarova KS, Kudritska M, et al. (July 2008). "A novel family of sequence-specific endoribonucleases associated with the clustered regularly interspaced short palindromic repeats". The Journal of Biological Chemistry. 283 (29): 20361–71. doi:10.1074/jbc.M803225200. PMC 2459268. PMID 18482976.
- ^ Nam KH, Ding F, Haitjema C, Huang Q, DeLisa MP, Ke A (October 2012). "Double-stranded endonuclease activity in Bacillus halodurans clustered regularly interspaced short palindromic repeats (CRISPR)-associated Cas2 protein". The Journal of Biological Chemistry. 287 (43): 35943–52. doi:10.1074/jbc.M112.382598. PMC 3476262. PMID 22942283.
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