Glutamin sintetase

Glutamine synthetase,
beta-Grasp domain
Glutamine synthetase,; beta-Grasp domain
Identifikasi
Simbol	Gln-synt_N
Pfam	PF03951
InterPro	IPR008147
PROSITE	PDOC00162
SCOP	2gls
SUPERFAMILY	2gls
Pfam
Struktur protein yang tersedia:
Pfam	struktur
PDB	RCSB PDB; PDBe; PDBj
PDBsum	ringkasan struktur

Pencarian
PMC	artikel
PubMed	artikel
NCBI	protein

glutamate—ammonia ligase
glutamate—ammonia ligase
	Active site between two monomers of glutamine synthetase from Salmonella typhimurium. Cation binding sites are yellow and orange; ADP is pink; phosphinothricin is blue.
Pengidentifikasi
Nomor EC	6.3.1.2
Nomor CAS	9023-70-5
Basis data
IntEnz	tinjauan IntEnz
BRENDA	entri BRENDA
ExPASy	tinjauan NiceZyme
KEGG	entri KEGG
MetaCyc	jalur metabolik
PRIAM	profil
Struktur PDB	RCSB PDB PDBe PDBsum
Ontologi Gen	AmiGO / EGO
PMC
Pencarian
PMC	artikel
PubMed	artikel
NCBI	protein

Glutamine synthetase,
catalytic domain

12-subunit enzyme glutamine synthetase from Salmonella typhimurium.^[2]

Identifikasi

Simbol

Gln-synt_C

Klan Pfam

Struktur protein yang tersedia:
Pfam	struktur
PDB	RCSB PDB; PDBe; PDBj
PDBsum	ringkasan struktur

glutamate-ammonia ligase (glutamine synthetase)

Pengidentifikasi

Simbol

GLUL

Simbol alternatif

GLNS

Data lain

Chr. 1 q31

Pencarian
Struktur	Swiss-model
Domain	InterPro

Glutamin sintetase (GS) (EC 6.3.1.2)^[3] adalah enzim yang memainkan peran penting dalam metabolisme nitrogen dengan mengkatalisis kondensasi glutamat dan amonia untuk membentuk glutamin:

Glutamat + ATP + NH₃ → Glutamin + ADP + fosfat

Referensi

^ PDB: 1FPY; Gill HS, Eisenberg D (February 2001). "The crystal structure of phosphinothricin in the active site of glutamine synthetase illuminates the mechanism of enzymatic inhibition". Biochemistry. 40 (7): 1903–12. doi:10.1021/bi002438h. PMID 11329256.
^ PDB: 2GLS; Yamashita MM, Almassy RJ, Janson CA, Cascio D, Eisenberg D (October 1989). "Refined atomic model of glutamine synthetase at 3.5 A resolution". J. Biol. Chem. 264 (30): 17681–90. PMID 2572586.
^ Eisenberg D, Almassy RJ, Janson CA, Chapman MS, Suh SW, Cascio D, Smith WW (1987). "Some evolutionary relationships of the primary biological catalysts glutamine synthetase and RuBisCO". Cold Spring Harb. Symp. Quant. Biol. 52: 483–90. doi:10.1101/sqb.1987.052.01.055. PMID 2900091.

Pranala luar

InterPro entry Diarsipkan 2018-02-02 di Wayback Machine.
RCSB PDB molecule of the month Diarsipkan 2007-11-13 di Wayback Machine.

Templat:Ligase Templat:Amino acid metabolism enzymes

[pmid11329256-1] PDB: 1FPY; Gill HS, Eisenberg D (February 2001). "The crystal structure of phosphinothricin in the active site of glutamine synthetase illuminates the mechanism of enzymatic inhibition". Biochemistry. 40 (7): 1903–12. doi:10.1021/bi002438h. PMID 11329256.

[pmid2572586-2] PDB: 2GLS; Yamashita MM, Almassy RJ, Janson CA, Cascio D, Eisenberg D (October 1989). "Refined atomic model of glutamine synthetase at 3.5 A resolution". J. Biol. Chem. 264 (30): 17681–90. PMID 2572586.

[pmid2900091-3] Eisenberg D, Almassy RJ, Janson CA, Chapman MS, Suh SW, Cascio D, Smith WW (1987). "Some evolutionary relationships of the primary biological catalysts glutamine synthetase and RuBisCO". Cold Spring Harb. Symp. Quant. Biol. 52: 483–90. doi:10.1101/sqb.1987.052.01.055. PMID 2900091.

[1]

[2]

[3]