Perfenazin
 | |
| Data klinis | |
|---|---|
| AHFS/Drugs.com | monograph |
| MedlinePlus | a682165 |
| Kategori kehamilan |
|
| Rute pemberian | Oral dan intramuskular |
| Kelas obat | Antipsikotik tipikal |
| Kode ATC | |
| Status hukum | |
| Status hukum | |
| Data farmakokinetika | |
| Bioavailabilitas | 40% |
| Metabolisme | hati |
| Waktu paruh eliminasi | 8–12 (hingga 20) jam |
| Pengenal | |
| |
| Nomor CAS | |
| PubChem CID | |
| IUPHAR/BPS | |
| DrugBank | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEBI | |
| ChEMBL | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.000.346 |
| Data sifat kimia dan fisik | |
| Rumus | C21H26ClN3OS |
| Massa molar | 403,97 g·mol−1 |
| Model 3D (JSmol) | |
| |
| |
| (verify) | |
Perfenazin adalah suatu obat antipsikotik tipikal. Secara kimia, obat ini diklasifikasikan sebagai piperazinil fenotiazina. Awalnya dipasarkan di Amerika Serikat dengan nama Trilafon. Obat ini telah digunakan secara klinis selama beberapa dekade.
Perfenazin kira-kira sepuluh kali lebih poten daripada klorpromazin pada reseptor dopamin-2 (D2);[2] sehingga perfenazin dianggap sebagai antipsikotik dengan potensi sedang.[3][4]
Referensi
- ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (dalam bahasa Brazilian Portuguese). Diário Oficial da União (dipublikasikan 2023-04-04). Diarsipkan dari versi aslinya tanggal 2023-08-03. Diakses tanggal 2023-08-16.
- ^ Rees L (August 1960). "Chlorpromazine and allied phenothiazine derivatives". British Medical Journal. 2 (5197): 522–5. doi:10.1136/bmj.2.5197.522. PMC 2097091. PMID 14436902.
- ^ Ascher-Svanum H, Zhu B, Faries D, Landbloom R, Swartz M, Swanson J (February 2006). "Time to discontinuation of atypical versus typical antipsychotics in the naturalistic treatment of schizophrenia". BMC Psychiatry. 6 8. doi:10.1186/1471-244X-6-8. PMC 1402287. PMID 16504026.
- ^ Freudenreich O (2007). "Treatment of psychotic disorders". Psychotic disorders. Practical Guides in Psychiatry. Lippincott Williams & Wilkins. hlm. 88. ISBN 978-0-7817-8543-3. Diakses tanggal 2009-06-22.
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