S1PR1

S1PR1
Struktur yang tersedia
PDB	Pencarian ortolog: PDBe RCSB
Daftar kode ID PDB
	3V2W, 3V2Y
Pengidentifikasi
Alias	S1PR1, CD363, CHEDG1, D1S3362, ECGF1, EDG-1, EDG1, S1P1, sphingosine-1-phosphate receptor 1
ID Eksternal	OMIM: 601974; MGI: 1096355; HomoloGene: 1071; GeneCards: S1PR1; OMA:S1PR1 - orthologs
Lokasi gen (Manusia)
Kr.	Kromosom 1 (manusia)
Akhir	101,243,713 pb
Pola ekspresi RNA
	Ekspresi tertinggi di
	right lung; ; upper lobe of left lung; ; ventricular zone; ; Granulosit; ; subcutaneous adipose tissue; ; apex of heart; ; left ventricle; ; right auricle of heart; ; caudate nucleus; ; right lobe of thyroid gland;
	Ekspresi tertinggi di
	right lung lobe; ; globus pallidus; ; dentate gyrus of hippocampal formation granule cell; ; Atrium (anatomi); ; left lung; ; superior frontal gyrus; ; inferior colliculi; ; mesenteric lymph nodes; ; cerebellar cortex; ; primary visual cortex;
	Referensi data ekspresi selengkapnya
	Data ekspresi referensi lebih lanjut
Ontologi gen
Fungsi molekuler	sphingolipid binding; sphingosine-1-phosphate receptor activity; G protein-coupled receptor activity; signal transducer activity; G protein-coupled receptor binding; Ikatan protein plasma;
Komponen seluler	komponen integral membran; endosom; membran; intrinsic component of plasma membrane; membran sel; membrane raft; external side of plasma membrane; nucleoplasm; intracellular membrane-bounded organelle;
Proses biologis	actin cytoskeleton reorganization; T cell migration; G protein-coupled receptor signaling pathway; heart trabecula morphogenesis; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; sphingosine-1-phosphate receptor signaling pathway; positive regulation of cell migration; regulation of bone mineralization; transmission of nerve impulse; chemotaxis; positive regulation of positive chemotaxis; positive regulation of GTPase activity; brain development; regulation of cell adhesion; Adhesi sel; Angiogenesis; neuron differentiation; positive regulation of cell population proliferation; endothelial cell differentiation; negative regulation of stress fiber assembly; regulation of bone resorption; Migrasi sel; signal transduction; lamellipodium assembly; positive regulation of transcription by RNA polymerase II; cardiac muscle tissue growth involved in heart morphogenesis; positive regulation of smooth muscle cell proliferation; blood vessel maturation; leukocyte chemotaxis; cytokine-mediated signaling pathway;
	Sumber:Amigo / QuickGO
Ortologi
	1901
	13609
	ENSG00000170989
	ENSMUSG00000045092
	P21453
	O08530
	NM_001400; NM_001320730
	NM_007901
	NP_001307659; NP_001391
	NP_031927
	Wikidata
Lihat/Sunting Manusia	Lihat/Sunting Tikus

Sphingosine-1-fosfat reseptor 1 (S1P reseptor 1 atau S1P1), juga dikenal sebagai endotel diferensiasi gen 1 (EDG1) adalah protein yang pada manusia dikodekan oleh gen S1PR1. S1PR1 adalah GReseptor terhubung-protein G yang mengikat sinyal molekul bioaktif sphingosine 1-fosfat (S1P). S1PR1 merupakan anggota subfamili sphingosine-1-fosfat reseptor yang terdiri dari lima anggota (S1PR1-5). S1PR1 awalnya diidentifikasi sebagai transkrip yang melimpah di sel endotel^[4] dan memiliki peran penting dalam mengatur struktur sel endotel sitoskeleton, migrasi, pembentukan jaringan kapiler dan pematangan pembuluh darah.^[5]^[6] selain itu, sinyal S1PR1 penting dalam regulasi pematangan, migrasi dan penyaluran limfosit,.^[7]^[8]

Referensi

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170989 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors". J. Biol. Chem. 265 (16): 9308–13. June 1990. PMID 2160972.
^ "Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1". Science. 279 (5356): 1552–5. March 1998. doi:10.1126/science.279.5356.1552. PMID 9488656.
^ "Ligand-induced trafficking of the sphingosine-1-phosphate receptor EDG-1". Mol. Biol. Cell. 10 (4): 1179–90. April 1999. doi:10.1091/mbc.10.4.1179. PMC 25247. PMID 10198065.
^ "Expression of the sphingosine 1-phosphate receptor, S1P1, on T-cells controls thymic emigration". J. Biol. Chem. 279 (15): 15396–401. April 2004. doi:10.1074/jbc.M314291200. PMID 14732704. Pemeliharaan CS1: DOI bebas tanpa ditandai (link)
^ "Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1". Nature. 427 (6972): 355–60. January 2004. doi:10.1038/nature02284. PMID 14737169.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000170989 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Hla_1990-4] "An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors". J. Biol. Chem. 265 (16): 9308–13. June 1990. PMID 2160972.

[Lee_1998-5] "Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1". Science. 279 (5356): 1552–5. March 1998. doi:10.1126/science.279.5356.1552. PMID 9488656.

[Liu_1999-6] "Ligand-induced trafficking of the sphingosine-1-phosphate receptor EDG-1". Mol. Biol. Cell. 10 (4): 1179–90. April 1999. doi:10.1091/mbc.10.4.1179. PMC 25247. PMID 10198065.

[Allende_2004-7] "Expression of the sphingosine 1-phosphate receptor, S1P1, on T-cells controls thymic emigration". J. Biol. Chem. 279 (15): 15396–401. April 2004. doi:10.1074/jbc.M314291200. PMID 14732704. Pemeliharaan CS1: DOI bebas tanpa ditandai (link)

[Matloubian_2004-8] "Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1". Nature. 427 (6972): 355–60. January 2004. doi:10.1038/nature02284. PMID 14737169.

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S1PR1

Referensi

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