TFAM
TFAM (Transcription factor A, mitochondrial) هوَ بروتين يُشَفر بواسطة جين TFAM في الإنسان.[1][2]
الوظيفة
![[أيقونة]](https://infokontak.com/ar/%D9%85%D9%84%D9%81:Crystal_xedit.svg){kind=small} | هذا القسم فارغ أو غير مكتمل. ساهم في توسيعه. (يوليو 2018) |
الأهمية السريرية
| هذا القسم فارغ أو غير مكتمل. ساهم في توسيعه. (يوليو 2018) |
المراجع
- ^ Tiranti V، Rossi E، Ruiz-Carrillo A، Rossi G، Rocchi M، DiDonato S، Zuffardi O، Zeviani M (يوليو 1995). "Chromosomal localization of mitochondrial transcription factor A (TCF6), single-stranded DNA-binding protein (SSBP), and endonuclease G (ENDOG), three human housekeeping genes involved in mitochondrial biogenesis". Genomics. ج. 25 ع. 2: 559–64. DOI:10.1016/0888-7543(95)80058-T. PMID:7789991.
- ^ "Entrez Gene: TFAM transcription factor A, mitochondrial". مؤرشف من الأصل في 2010-12-05.
قراءة متعمقة
- Tominaga K، Akiyama S، Kagawa Y، Ohta S (1992). "Upstream region of a genomic gene for human mitochondrial transcription factor 1". Biochim. Biophys. Acta. ج. 1131 ع. 2: 217–9. DOI:10.1016/0167-4781(92)90082-b. PMID:1610904.
- Fisher RP، Lisowsky T، Parisi MA، Clayton DA (1992). "DNA wrapping and bending by a mitochondrial high mobility group-like transcriptional activator protein". J. Biol. Chem. ج. 267 ع. 5: 3358–67. PMID:1737790.
- Parisi MA، Clayton DA (1991). "Similarity of human mitochondrial transcription factor 1 to high mobility group proteins". Science. ج. 252 ع. 5008: 965–9. DOI:10.1126/science.2035027. PMID:2035027.
- Tominaga K، Hayashi J، Kagawa Y، Ohta S (1993). "Smaller isoform of human mitochondrial transcription factor 1: its wide distribution and production by alternative splicing". Biochem. Biophys. Res. Commun. ج. 194 ع. 1: 544–51. DOI:10.1006/bbrc.1993.1854. PMID:8333869.
- Larsson NG، Oldfors A، Garman JD، Barsh GS، Clayton DA (1997). "Down-regulation of mitochondrial transcription factor A during spermatogenesis in humans". Hum. Mol. Genet. ج. 6 ع. 2: 185–91. DOI:10.1093/hmg/6.2.185. PMID:9063738.
- Lezza AM، Pesce V، Cormio A، Fracasso F، Vecchiet J، Felzani G، Cantatore P، Gadaleta MN (2001). "Increased expression of mitochondrial transcription factor A and nuclear respiratory factor-1 in skeletal muscle from aged human subjects". FEBS Lett. ج. 501 ع. 1: 74–8. DOI:10.1016/S0014-5793(01)02628-X. PMID:11457459.
- Takamatsu C، Umeda S، Ohsato T، Ohno T، Abe Y، Fukuoh A، Shinagawa H، Hamasaki N، Kang D (2002). "Regulation of mitochondrial D-loops by transcription factor A and single-stranded DNA-binding protein". EMBO Rep. ج. 3 ع. 5: 451–6. DOI:10.1093/embo-reports/kvf099. PMC:1084112. PMID:11964388.
- Falkenberg M، Gaspari M، Rantanen A، Trifunovic A، Larsson NG، Gustafsson CM (2002). "Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA". Nat. Genet. ج. 31 ع. 3: 289–94. DOI:10.1038/ng909. PMID:12068295.
- Reyes A، Mezzina M، Gadaleta G (2002). "Human mitochondrial transcription factor A (mtTFA): gene structure and characterization of related pseudogenes". Gene. ج. 291 ع. 1–2: 223–32. DOI:10.1016/S0378-1119(02)00600-5. PMID:12095695.
- Yoshida Y، Izumi H، Ise T، Uramoto H، Torigoe T، Ishiguchi H، Murakami T، Tanabe M، Nakayama Y، Itoh H، Kasai H، Kohno K (2002). "Human mitochondrial transcription factor A binds preferentially to oxidatively damaged DNA". Biochem. Biophys. Res. Commun. ج. 295 ع. 4: 945–51. DOI:10.1016/S0006-291X(02)00757-X. PMID:12127986.
- Garrido N، Griparic L، Jokitalo E، Wartiovaara J، van der Bliek AM، Spelbrink JN (2003). "Composition and dynamics of human mitochondrial nucleoids". Mol. Biol. Cell. ج. 14 ع. 4: 1583–96. DOI:10.1091/mbc.E02-07-0399. PMC:153124. PMID:12686611.
- Yoshida Y، Izumi H، Torigoe T، Ishiguchi H، Itoh H، Kang D، Kohno K (2003). "P53 physically interacts with mitochondrial transcription factor A and differentially regulates binding to damaged DNA". Cancer Res. ج. 63 ع. 13: 3729–34. PMID:12839966.
- McCulloch V، Shadel GS (2003). "Human mitochondrial transcription factor B1 interacts with the C-terminal activation region of h-mtTFA and stimulates transcription independently of its RNA methyltransferase activity". Mol. Cell. Biol. ج. 23 ع. 16: 5816–24. DOI:10.1128/MCB.23.16.5816-5824.2003. PMC:166325. PMID:12897151.
- Deschauer M، Kiefer R، Blakely EL، He L، Zierz S، Turnbull DM، Taylor RW (2003). "A novel Twinkle gene mutation in autosomal dominant progressive external ophthalmoplegia". Neuromuscul. Disord. ج. 13 ع. 7–8: 568–72. DOI:10.1016/S0960-8966(03)00071-3. PMID:12921794.
- Günther C، von Hadeln K، Müller-Thomsen T، Alberici A، Binetti G، Hock C، Nitsch RM، Stoppe G، Reiss J، Gal A، Finckh U (2005). "Possible association of mitochondrial transcription factor A (TFAM) genotype with sporadic Alzheimer disease". Neurosci. Lett. ج. 369 ع. 3: 219–23. DOI:10.1016/j.neulet.2004.07.070. PMID:15464268.
- Kanki T، Ohgaki K، Gaspari M، Gustafsson CM، Fukuoh A، Sasaki N، Hamasaki N، Kang D (2004). "Architectural role of mitochondrial transcription factor A in maintenance of human mitochondrial DNA". Mol. Cell. Biol. ج. 24 ع. 22: 9823–34. DOI:10.1128/MCB.24.22.9823-9834.2004. PMC:525493. PMID:15509786.
- Cam H، Balciunaite E، Blais A، Spektor A، Scarpulla RC، Young R، Kluger Y، Dynlacht BD (2004). "A common set of gene regulatory networks links metabolism and growth inhibition". Mol. Cell. ج. 16 ع. 3: 399–411. DOI:10.1016/j.molcel.2004.09.037. PMID:15525513.
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