ADM2
ADM2 jest protein koji je kod ljudi kodiran genom ADM2 sa hromosoma 22.[5][6]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 148 aminokiselina, a molekulska težina 15.865 Da.
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MARIPTAALG | CISLLCLQLP | GSLSRSLGGD | PRPVKPREPP | ARSPSSSLQP | ||||
| RHPAPRPVVW | KLHRALQAQR | GAGLAPVMGQ | PLRDGGRQHS | GPRRHSGPRR | ||||
| TQAQLLRVGC | VLGTCQVQNL | SHRLWQLMGP | AGRQDSAPVD | PSSPHSYG |
Funkcija
ADM2 pripada porodici kalcitoninskih (MIM 114130) povezanih peptidnih hormona važnih za regulaciju različitih fizioloških funkcija i hemijskog sastava tečnosti i tkiva (prema OMIM[6])
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000128165 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000054136 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Takei Y, Inoue K, Ogoshi M, Kawahara T, Bannai H, Miyano S (Jan 2004). "Identification of novel adrenomedullin in mammals: a potent cardiovascular and renal regulator". FEBS Lett. 556 (1–3): 53–8. doi:10.1016/S0014-5793(03)01368-1. PMID 14706825. S2CID 2063665.
- ^ a b "Entrez Gene: ADM2 adrenomedullin 2".
Dopumska literatura
- Kawai M (2004). "[Diagnosis of dermatophytoses: conventional methods and recent molecular biological methods]". Nihon Ishinkin Gakkai Zasshi (Japanese Journal of Medical Mycology). 44 (4): 261–4. doi:10.3314/jjmm.44.261. PMID 14615790.
- Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Roh J, Chang CL, Bhalla A, et al. (2004). "Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexes". J. Biol. Chem. 279 (8): 7264–74. doi:10.1074/jbc.M305332200. PMID 14615490.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
- Takahashi K, Kikuchi K, Maruyama Y, et al. (2006). "Immunocytochemical localization of adrenomedullin 2/intermedin-like immunoreactivity in human hypothalamus, heart and kidney". Peptides. 27 (6): 1383–9. doi:10.1016/j.peptides.2005.11.004. PMID 16359754. S2CID 27665694.
- Kindt F, Wiegand S, Löser C, et al. (2007). "Intermedin: a skin peptide that is downregulated in atopic dermatitis". J. Invest. Dermatol. 127 (3): 605–13. doi:10.1038/sj.jid.5700576. PMID 17008878.
- Morimoto R, Satoh F, Murakami O, et al. (2007). "Expression of adrenomedullin2/intermedin in human brain, heart, and kidney". Peptides. 28 (5): 1095–103. doi:10.1016/j.peptides.2007.01.018. PMID 17346853. S2CID 23005775.
Vanjski linkovi
- Lokacija ljudskog genoma ADM2 i stranica sa detaljima o genu ADM2 u UCSC Genome Browseru.
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Index:
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