AEBP1
AE-vezujući protein 1 je protein koji je kod ljudi kodiran genom AEBP1.[5]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 1.158 aminokiselina, а molekulska težina 130.929 Da.[6]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MAAVRGAPLL | SCLLALLALC | PGGRPQTVLT | DDEIEEFLEG | FLSELEPEPR | ||||
| EDDVEAPPPP | EPTPRVRKAQ | AGGKPGKRPG | TAAEVPPEKT | KDKGKKGKKD | ||||
| KGPKVPKESL | EGSPRPPKKG | KEKPPKATKK | PKEKPPKATK | KPKEKPPKAT | ||||
| KKPKEKPPKA | TKKPPSGKRP | PILAPSETLE | WPLPPPPSPG | PEELPQEGGA | ||||
| PLSNNWQNPG | EETHVEAREH | QPEPEEETEQ | PTLDYNDQIE | REDYEDFEYI | ||||
| RRQKQPRPPP | SRRRRPERVW | PEPPEEKAPA | PAPEERIEPP | VKPLLPPLPP | ||||
| DYGDGYVIPN | YDDMDYYFGP | PPPQKPDAER | QTDEEKEELK | KPKKEDSSPK | ||||
| EETDKWAVEK | GKDHKEPRKG | EELEEEWTPT | EKVKCPPIGM | ESHRIEDNQI | ||||
| RASSMLRHGL | GAQRGRLNMQ | TGATEDDYYD | GAWCAEDDAR | TQWIEVDTRR | ||||
| TTRFTGVITQ | GRDSSIHDDF | VTTFFVGFSN | DSQTWVMYTN | GYEEMTFHGN | ||||
| VDKDTPVLSE | LPEPVVARFI | RIYPLTWNGS | LCMRLEVLGC | SVAPVYSYYA | ||||
| QNEVVATDDL | DFRHHSYKDM | RQLMKVVNEE | CPTITRTYSL | GKSSRGLKIY | ||||
| AMEISDNPGE | HELGEPEFRY | TAGIHGNEVL | GRELLLLLMQ | YLCREYRDGN | ||||
| PRVRSLVQDT | RIHLVPSLNP | DGYEVAAQMG | SEFGNWALGL | WTEEGFDIFE | ||||
| DFPDLNSVLW | GAEERKWVPY | RVPNNNLPIP | ERYLSPDATV | STEVRAIIAW | ||||
| MEKNPFVLGA | NLNGGERLVS | YPYDMARTPT | QEQLLAAAMA | AARGEDEDEV | ||||
| SEAQETPDHA | IFRWLAISFA | SAHLTLTEPY | RGGCQAQDYT | GGMGIVNGAK | ||||
| WNPRTGTIND | FSYLHTNCLE | LSFYLGCDKF | PHESELPREW | ENNKEALLTF | ||||
| MEQVHRGIKG | VVTDEQGIPI | ANATISVSGI | NHGVKTASGG | DYWRILNPGE | ||||
| YRVTAHAEGY | TPSAKTCNVD | YDIGATQCNF | ILARSNWKRI | REIMAMNGNR | ||||
| PIPHIDPSRP | MTPQQRRLQQ | RRLQHRLRLR | AQMRLRRLNA | TTTLGPHTVP | ||||
| PTLPPAPATT | LSTTIEPWGL | IPPTTAGWEE | SETETYTEVV | TEFGTEVEPE | ||||
| FGTKVEPEFE | TQLEPEFETQ | LEPEFEEEEE | EEKEEEIATG | QAFPFTTVET | ||||
| YTVNFGDF |
Funkcija
AE-vezujući protein 1 je član proteinske porodice karboksipeptidaza A. Protein može funkcionirati kao transkripcijski represor i imati ulogu u adipogenezi i diferencijaciji ćelija u glatkim mišićima. Studije na miševima sugeriraju da gen AEBP1 koji kodira proteinske funkcije u zacjeljivanju rana i razvoju trbušnog zida. Prekomjerna ekspresija ovog gena povezana je s glioblastomomom.[5]
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000106624 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020473 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: AE binding protein 1".
- ^ "UniProt, Q8IUX7" (jezik: engleski). Pristupljeno 22. 9. 2021.
Dopunska literatura
- Tumelty KE, Smith BD, Nugent MA, Layne MD (2014). "Aortic carboxypeptidase-like protein (ACLP) enhances lung myofibroblast differentiation through transforming growth factor β receptor-dependent and -independent pathways". Journal of Biological Chemistry. 289 (5): 2526–36. doi:10.1074/jbc.M113.502617. PMC 3908388. PMID 24344132.
- Lyons PJ, Muise AM, Ro HS (2005). "MAPK modulates the DNA binding of adipocyte enhancer-binding protein 1". Biochemistry. 44 (3): 926–31. doi:10.1021/bi0480178. PMID 15654748.
- Majdalawieh A, Ro HS (2010). "PPARgamma1 and LXRalpha face a new regulator of macrophage cholesterol homeostasis and inflammatory responsiveness, AEBP1". Nuclear Receptor Signaling. 8: e004. doi:10.1621/nrs.08004. PMC 2858268. PMID 20419060.
- Muise AM, Ro HS (1999). "Enzymic characterization of a novel member of the regulatory B-like carboxypeptidase with transcriptional repression function: Stimulation of enzymic activity by its target DNA". The Biochemical Journal. 343 (2): 341–5. doi:10.1042/0264-6021:3430341. PMC 1220559. PMID 10510298.
- Feldkamp ML, Bowles NE, Botto LD (2012). "AEBP1 gene variants in infants with gastroschisis". Birth Defects Research Part A: Clinical and Molecular Teratology. 94 (9): 738–42. doi:10.1002/bdra.23041. PMID 22821744.
- Layne MD, Yet SF, Maemura K, Hsieh CM, Bernfield M, Perrella MA, Lee ME (2001). "Impaired abdominal wall development and deficient wound healing in mice lacking aortic carboxypeptidase-like protein". Molecular and Cellular Biology. 21 (15): 5256–61. doi:10.1128/MCB.21.15.5256-5261.2001. PMC 87249. PMID 11438679.
- Ohno I, Hashimoto J, Shimizu K, Takaoka K, Ochi T, Matsubara K, Okubo K (1996). "A cDNA cloning of human AEBP1 from primary cultured osteoblasts and its expression in a differentiating osteoblastic cell line". Biochemical and Biophysical Research Communications. 228 (2): 411–4. doi:10.1006/bbrc.1996.1675. PMID 8920928.
- Majdalawieh A, Ro HS (2010). "Regulation of Ikappa Balpha function and NF-kappaB signaling: AEBP1 is a novel proinflammatory mediator in macrophages". Mediators of Inflammation. 2010: 823821. doi:10.1155/2010/823821. PMC 2855089. PMID 20396415.
- Song L, Fricker LD (1997). "Cloning and expression of human carboxypeptidase Z, a novel metallocarboxypeptidase". The Journal of Biological Chemistry. 272 (16): 10543–50. doi:10.1074/jbc.272.16.10543. PMID 9099699.
Vanjski linkovi
- Lokacija ljudskog genoma AEBP1 i stranica sa detaljima o genu AEBP1 u UCSC Genome Browseru.
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