AIM1

AIM1
Dostupne strukture
PDB	Pretraga Human UniProta: PDBe RCSB
Spisak PDB ID kodova
	3CW3, 2DAD,%%s2DAD
Identifikatori
Aliasi	CRYBG1
Vanjski ID-jevi	OMIM: 601797 MGI: 109544 HomoloGene: 18168 GeneCards: CRYBG1
Lokacija gena (čovjek)
Hrom.	Hromosom 6 (čovjek)
Kraj	106,572,017 bp
Lokacija gena (miš)
Hrom.	Hromosom 10 (miš)
Kraj	44,024,849 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• carbohydrate binding; • molekularna funkcija;
Ćelijska komponenta	• ćelijska komponenta;
Biološki proces	• GO:0022610 biološki proces;
	Izvori:Amigo / QuickGO
Ortolozi
	202
	11630
	ENSG00000112297
	ENSMUSG00000019866
	Q9Y4K1; Q96QW7
	n/a
	NM_001624; NM_001371242
	NM_172393; NM_001368305; NM_001368306
	NP_001615; NP_001358171
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Nedostajući protein melanoma 1 jest protein koji je kod ljudi kodiran genom AIM1.^[5]^[6]^[7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 1723 aminokiseline, а molekulska težina 188.676 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MEKRSSGRRS	GRRRGSQKST	DSPGADAELP	ESAARDDAVF	DDEVAPNAAS
DNASAEKKVK	SPRAALDGGV	ASAASPESKP	SPGTKGQLRG	ESDRSKQPPP
ASSPTKRKGR	SRALEAVPAP	PASGPRAPAK	ESPPKRVPDP	SPVTKGTAAE
SGEEAARAIP	RELPVKSSSL	LPEIKPEHKR	GPLPNHFNGR	AEGGRSRELG
RAAGAPGASD	ADGLKPRNHF	GVGRSTVTTK	VTLPAKPKHV	ELNLKTPKNL
DSLGNEHNPF	SQPVHKGNTA	TKISLFENKR	TNSSPRHTDI	RGQRNTPASS
KTFVGRAKLN	LAKKAKEMEQ	PEKKVMPNSP	QNGVLVKETA	IETKVTVSEE
EILPATRGMN	GDSSENQALG	PQPNQDDKAD	VQTDAGCLSE	PVASALIPVK
DHKLLEKEDS	EAADSKSLVL	ENVTDTAQDI	PTTVDTKDLP	PTAMPKPQHT
FSDSQSPAES	SPGPSLSLSA	PAPGDVPKDT	CVQSPISSFP	CTDLKVSENH
KGCVLPVSRQ	NNEKMPLLEL	GGETTPPLST	ERSPEAVGSE	CPSRVLVQVR
SFVLPVESTQ	DVSSQVIPES	SEVREVQLPT	CHSNEPEVVS	VASCAPPQEE
VLGNEHSHCT	AELAAKSGPQ	VIPPASEKTL	PIQAQSQGSR	TPLMAESSPT
NSPSSGNHLA	TPQRPDQTVT	NGQDSPASLL	NISAGSDDSV	FDSSSDMEKF
TEIIKQMDSA	VCMPMKRKKA	RMPNSPAPHF	AMPPIHEDHL	EKVFDPKVFT
FGLGKKKESQ	PEMSPALHLM	QNLDTKSKLR	PKRASAEQSV	LFKSLHTNTN
GNSEPLVMPE	INDKENRDVT	NGGIKRSRLE	KSALFSSLLS	SLPQDKIFSP
SVTSVNTMTT	AFSTSQNGSL	SQSSVSQPTT	EGAPPCGLNK	EQSNLLPDNS
LKVFNFNSSS	TSHSSLKSPS	HMEKYPQKEK	TKEDLDSRSN	LHLPETKFSE
LSKLKNDDME	KANHIESVIK	SNLPNCANSD	TDFMGLFKSS	RYDPSISFSG
MSLSDTMTLR	GSVQNKLNPR	PGKVVIYSEP	DVSEKCIEVF	SDIQDCSSWS
LSPVILIKVV	RGCWILYEQP	NFEGHSIPLE	EGELELSGLW	GIEDILERHE
EAESDKPVVI	GSIRHVVQDY	RVSHIDLFTE	PEGLGILSSY	FDDTEEMQGF
GVMQKTCSMK	VHWGTWLIYE	EPGFQGVPFI	LEPGEYPDLS	FWDTEEAYIG
SMRPLKMGGR	KVEFPTDPKV	VVYEKPFFEG	KCVELETGMC	SFVMEGGETE
EATGDDHLPF	TSVGSMKVLR	GIWVAYEKPG	FTGHQYLLEE	GEYRDWKAWG
GYNGELQSLR	PILGDFSNAH	MIMYSEKNFG	SKGSSIDVLG	IVANLKETGY
GVKTQSINVL	SGVWVAYENP	DFTGEQYILD	KGFYTSFEDW	GGKNCKISSV
QPICLDSFTG	PRRRNQIHLF	SEPQFQGHSQ	SFEETTSQID	DSFSTKSCRV
SGGSWVVYDG	ENFTGNQYVL	EEGHYPCLSA	MGCPPGATFK	SLRFIDVEFS
EPTIILFERE	DFKGKKIELN	AETVNLRSLG	FNTQIRSVQV	IGGIWVTYEY
GSYRGRQFLL	SPAEVPNWYE	FSGCRQIGSL	RPFVQKRIYF	RLRNKATGLF
MSTNGNLEDL	KLLRIQVMED	VGADDQIWIY	QEGCIKCRIA	EDCCLTIVGS
LVTSGSKLGL	ALDQNADSQF	WSLKSDGRIY	SKLKPNLVLD	IKGGTQYDQN
HIILNTVSKE	KFTQVWEAMV	LYT

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000112297 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019866 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Millikin D, Meese E, Vogelstein B, Witkowski C, Trent J (Nov 1991). "Loss of heterozygosity for loci on the long arm of chromosome 6 in human malignant melanoma". Cancer Research. 51 (20): 5449–53. PMID 1680551.
^ Rajini B, Graham C, Wistow G, Sharma Y (Apr 2003). "Stability, homodimerization, and calcium-binding properties of a single, variant betagamma-crystallin domain of the protein absent in melanoma 1 (AIM1)". Biochemistry. 42 (15): 4552–9. doi:10.1021/bi027384l. PMID 12693952.
^ "Entrez Gene: AIM1 absent in melanoma 1".
^ "UniProt, Q9Y4K1" (jezik: engleski). Pristupljeno 6. 10. 2021.

Dopunska literatura

Ray ME, Su YA, Meltzer PS, Trent JM (1996). "Isolation and characterization of genes associated with chromosome-6 mediated tumor suppression in human malignant melanoma". Oncogene. 12 (12): 2527–33. PMID 8700511.
Ray ME, Wistow G, Su YA, et al. (1997). "AIM1, a novel non-lens member of the betagamma-crystallin superfamily, is associated with the control of tumorigenicity in human malignant melanoma". Proceedings of the National Academy of Sciences of the United States of America. 94 (7): 3229–34. doi:10.1073/pnas.94.7.3229. PMC 20351. PMID 9096375.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nature Genetics. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Aravind P, Rajini B, Sharma Y, Sankaranarayanan R (2006). "Crystallization and preliminary X-ray crystallographic investigations on a betagamma-crystallin domain of absent in melanoma 1 (AIM1), a protein from Homo sapiens". Acta Crystallographica Section F. 62 (Pt 3): 282–4. doi:10.1107/S1744309106005380. PMC 2197174. PMID 16511323.

Vanjski linkovi

Lokacija ljudskog genoma AIM1 i stranica sa detaljima o genu AIM1 u UCSC Genome Browseru.
PDBe-KB provides an overview of all the structure information available in the PDB for Human Beta/gamma crystallin domain-containing protein 1 (AIM1)

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000112297 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000019866 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1680551-5] Millikin D, Meese E, Vogelstein B, Witkowski C, Trent J (Nov 1991). "Loss of heterozygosity for loci on the long arm of chromosome 6 in human malignant melanoma". Cancer Research. 51 (20): 5449–53. PMID 1680551.

[pmid12693952-6] Rajini B, Graham C, Wistow G, Sharma Y (Apr 2003). "Stability, homodimerization, and calcium-binding properties of a single, variant betagamma-crystallin domain of the protein absent in melanoma 1 (AIM1)". Biochemistry. 42 (15): 4552–9. doi:10.1021/bi027384l. PMID 12693952.

[entrez-7] "Entrez Gene: AIM1 absent in melanoma 1".

[UniProt-8] "UniProt, Q9Y4K1" (jezik: engleski). Pristupljeno 6. 10. 2021.

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AIM1

Aminokiselinska sekvenca

Reference

Dopunska literatura

Vanjski linkovi

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