ALKBH3
AlkB homolog 3 alfa-ketoglutarat dioksigenaze je protein koji je kod ljudi kodiran genom ALKBH3.[5]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 286 aminokiselina, a molekulska težina 33.375 Da.[6]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MEEKRRRARV | QGAWAAPVKS | QAIAQPATTA | KSHLHQKPGQ | TWKNKEHHLS | ||||
| DREFVFKEPQ | QVVRRAPEPR | VIDREGVYEI | SLSPTGVSRV | CLYPGFVDVK | ||||
| EADWILEQLC | QDVPWKQRTG | IREDITYQQP | RLTAWYGELP | YTYSRITMEP | ||||
| NPHWHPVLRT | LKNRIEENTG | HTFNSLLCNL | YRNEKDSVDW | HSDDEPSLGR | ||||
| CPIIASLSFG | ATRTFEMRKK | PPPEENGDYT | YVERVKIPLD | HGTLLIMEGA | ||||
| TQADWQHRVP | KEYHSREPRV | NLTFRTVYPD | PRGAPW |
Funkcija
AlkB protein Escherichia coli štiti od citotoksičnosti metilacijskih agenasa, popravljanjem specifičnih molekulskih lezija DNK, nastalih u jednolančanoj DNK. ALKBH2 (MIM 610602) i ALKBH3 su homolozi AlkB-a 'E. coli koji kataliziraju uklanjanje 1-metiladenina i 3-metilcitozina (Duncan et al., 2002 PubMed 12486230]).
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000166199 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040174 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: AlkB homolog 3, alpha-ketoglutaratedependent dioxygenase". Pristupljeno 4. 3. 2017.
- ^ "UniProt, Q96Q83". Pristupljeno 15. 8. 2021.
Dopunska literatura
- Sundheim O, Vågbø CB, Bjørås M, Sousa MM, Talstad V, Aas PA, Drabløs F, Krokan HE, Tainer JA, Slupphaug G (2006). "Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage". EMBO J. 25 (14): 3389–97. doi:10.1038/sj.emboj.7601219. PMC 1523172. PMID 16858410.
- Liu BQ, Wu YD, Li PH, Wei JX, Zhang T, Liu RL (2007). "Prostate cancer antigen-1 as a potential novel marker for prostate cancer". Asian J. Androl. 9 (6): 821–6. doi:10.1111/j.1745-7262.2007.00279.x. PMID 17968469.
- Monsen VT, Sundheim O, Aas PA, Westbye MP, Sousa MM, Slupphaug G, Krokan HE (2010). "Divergent ß-hairpins determine double-strand versus single-strand substrate recognition of human AlkB-homologues 2 and 3". Nucleic Acids Res. 38 (19): 6447–55. doi:10.1093/nar/gkq518. PMC 2965238. PMID 20525795.
- Chen B, Liu H, Sun X, Yang CG (2010). "Mechanistic insight into the recognition of single-stranded and double-stranded DNA substrates by ABH2 and ABH3". Mol Biosyst. 6 (11): 2143–9. doi:10.1039/c005148a. PMID 20714506.
- Malki K, Uher R, Paya-Cano J, Binder E, Rietschel M, Zobel A, Mors O, Hauser J, Henigsberg N, Jerman B, Souery D, Placentino A, Ng MY, Cohen-Woods S, Sluyter F, Farmer A, Aitchison KJ, Craig IW, Lewis CM, McGuffin P, Schalkwyk LC (2011). "Convergent animal and human evidence suggests a role of PPM1A gene in response to antidepressants". Biol. Psychiatry. 69 (4): 360–5. doi:10.1016/j.biopsych.2010.08.011. PMID 20970119. S2CID 41571515.
- Tasaki M, Shimada K, Kimura H, Tsujikawa K, Konishi N (2011). "ALKBH3, a human AlkB homologue, contributes to cell survival in human non-small-cell lung cancer". Br. J. Cancer. 104 (4): 700–6. doi:10.1038/sj.bjc.6606012. PMC 3049579. PMID 21285982.
- Dango S, Mosammaparast N, Sowa ME, Xiong LJ, Wu F, Park K, Rubin M, Gygi S, Harper JW, Shi Y (2011). "DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation". Mol. Cell. 44 (3): 373–84. doi:10.1016/j.molcel.2011.08.039. PMC 3258846. PMID 22055184.
- Koike K, Ueda Y, Hase H, Kitae K, Fusamae Y, Masai S, Inagaki T, Saigo Y, Hirasawa S, Nakajima K, Ohshio I, Makino Y, Konishi N, Yamamoto H, Tsujikawa K (2012). "anti-tumor effect of AlkB homolog 3 knockdown in hormone- independent prostate cancer cells". Curr Cancer Drug Targets. 12 (7): 847–56. doi:10.2174/156800912802429283. PMID 22515525.
- Yamato I, Sho M, Shimada K, Hotta K, Ueda Y, Yasuda S, Shigi N, Konishi N, Tsujikawa K, Nakajima Y (2012). "PCA-1/ALKBH3 contributes to pancreatic cancer by supporting apoptotic resistance and angiogenesis". Cancer Res. 72 (18): 4829–39. doi:10.1158/0008-5472.CAN-12-0328. PMID 22826605.
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