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APOLD1

APOLD1
Identifikatori
AliasiAPOLD1
Vanjski ID-jeviOMIM: 612456 MGI: 2685921 HomoloGene: 12781 GeneCards: APOLD1
Lokacija gena (čovjek)
Hromosom 12 (čovjek)
Hrom.Hromosom 12 (čovjek)[1]
Hromosom 12 (čovjek)
Genomska lokacija za APOLD1
Genomska lokacija za APOLD1
Bend12p13.1Početak12,725,917 bp[1]
Kraj12,829,975 bp[1]
Lokacija gena (miš)
Hromosom 6 (miš)
Hrom.Hromosom 6 (miš)[2]
Hromosom 6 (miš)
Genomska lokacija za APOLD1
Genomska lokacija za APOLD1
Bend6|6 G1Početak134,958,681 bp[2]
Kraj134,963,799 bp[2]
Ontologija gena
Molekularna funkcija lipid binding
Ćelijska komponenta extracellular region
ćelijska membrana
integral component of membrane
membrana
nukleoplazma
citosol
Biološki proces Angiogeneza
response to hypoxia
lipid transport
Ćelijska diferencijacija
endothelial cell activation
lipoprotein metabolic process
regulation of endothelial cell differentiation
multicellular organism development
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_030817
NM_001130415

NM_001109914

RefSeq (bjelančevina)

NP_001123887
NP_110444

NP_001103384

Lokacija (UCSC)Chr 12: 12.73 – 12.83 MbChr 6: 134.96 – 134.96 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Apolipoprotein L sa domenom 1 je protein koji je kod ljudi kodiran genom APOLD1.[5] Nalazi se na hromosomu 12.[6]

APOLD1 je protein ranog odgovora endotelnih ćelija koji može imati ulogu u regulaciji signalizacije endotelnih ćelija i vaskularne funkcije (Regard et al., 2004 15102925).(prems OMIM, 2008)

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 279 aminokiselina, a molekulska težina 30.546 Da.[7].

1020304050
MFRAPCHRLRARGTRKARAGAWRGCTFPCLGKGMERPAAREPHGPDALRR
FQGLLLDRRGRLHGQVLRLREVARRLERLRRRSLVANVAGSSLSATGALA
AIVGLSLSPVTLGTSLLVSAVGLGVATAGGAVTITSDLSLIFCNSRELRR
VQEIAATCQDQMREILSCLEFFCRWQGCGDRQLLQCGRNASIALYNSVYF
IVFFGSRGFLIPRRAEGDTKVSQAVLKAKIQKLAESLESCTGALDELSEQ
LESRVQLCTKSSRGHDLKISADQRAGLFF

Reference

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000178878 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000090698 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Apolipoprotein L domain containing 1". Pristupljeno 2. 11. 2012.
  6. ^ APOLD1 apolipoprotein L domain containing 1 [ Homo sapiens (human) ] on NCBI
  7. ^ "UniProt, Q96LR9". Pristupljeno 6. 8. 2021.

Vanjski linkovi

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