AS3MT

AS3MT
Identifikatori
Aliasi	AS3MT
Vanjski ID-jevi	OMIM: 611806 MGI: 1929882 HomoloGene: 10754 GeneCards: AS3MT
Lokacija gena (čovjek)
Hrom.	Hromosom 10 (čovjek)
Kraj	102,901,899 bp
Lokacija gena (miš)
Hrom.	Hromosom 19 (miš)
Kraj	46,729,538 bp
Ontologija gena
Molekularna funkcija	• GO:0102674, GO:0102675 methyltransferase activity; • aktivnost sa transferazom; • methylarsonite methyltransferase activity; • arsenite methyltransferase activity;
Ćelijska komponenta	• citosol; • citoplazma;
Biološki proces	• toxin metabolic process; • arsonoacetate metabolic process; • Metilacija;
	Izvori:Amigo / QuickGO
Ortolozi
	57412
	57344
	ENSG00000214435
	ENSMUSG00000003559
	Q9HBK9
	Q91WU5
	NM_020682
	NM_020577
	NP_065733
	NP_065602
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Arsenit metiltransferaza je enzim koji je kod ljudi kodiran genom AS3MT.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca proteina je 375 aminokiselina, a molekulska težina 41.748^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MAALRDAEIQ	KDVQTYYGQV	LKRSADLQTN	GCVTTARPVP	KHIREALQNV
HEEVALRYYG	CGLVIPEHLE	NCWILDLGSG	SGRDCYVLSQ	LVGEKGHVTG
IDMTKGQVEV	AEKYLDYHME	KYGFQASNVT	FIHGYIEKLG	EAGIKNESHD
IVVSNCVINL	VPDKQQVLQE	AYRVLKHGGE	LYFSDVYTSL	ELPEEIRTHK
VLWGECLGGA	LYWKELAVLA	QKIGFCPPRL	VTANLITIQN	KELERVIGDC
RFVSATFRLF	KHSKTGPTKR	CQVIYNGGIT	GHEKELMFDA	NFTFKEGEIV
EVDEETAAIL	KNSRFAQDFL	IRPIGEKLPT	SGGCSALELK	DIITDPFKLA
EESDSMKSRC	VPDAAGGCCG	TKKSC

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000214435 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000003559 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lin S, Shi Q, Nix FB, Styblo M, Beck MA, Herbin-Davis KM, Hall LL, Simeonsson JB, Thomas DJ (mart 2002). "A novel S-adenosyl-L-methionine:arsenic(III) methyltransferase from rat liver cytosol". The Journal of Biological Chemistry. 277 (13): 10795–803. doi:10.1074/jbc.M110246200. PMID 11790780.
^ "Entrez Gene: AS3MT arsenic (+3 oxidation state) methyltransferase".
^ "UniProt, Q9HBK9". Pristupljeno 30. 8. 2021.

Dopunska literatura

Dheeman DS, Packianathan C, Pillai JK, Rosen BP (novembar 2014). "Pathway of human AS3MT arsenic methylation". Chemical Research in Toxicology. 27 (11): 1979–89. doi:10.1021/tx500313k. PMC 4237493. PMID 25325836.
Hernández A, Xamena N, Sekaran C, Tokunaga H, Sampayo-Reyes A, Quinteros D, Creus A, Marcos R (april 2008). "High arsenic metabolic efficiency in AS3MT287Thr allele carriers". Pharmacogenetics and Genomics. 18 (4): 349–55. doi:10.1097/FPC.0b013e3282f7f46b. PMID 18334919. S2CID 25842224.
Fujihara J, Kunito T, Agusa T, Yasuda T, Iida R, Fujii Y, Takeshita H (decembar 2007). "Population differences in the human arsenic (+3 oxidation state) methyltransferase (AS3MT) gene polymorphism detected by using genotyping method". Toxicology and Applied Pharmacology. 225 (3): 251–4. doi:10.1016/j.taap.2007.08.010. PMID 17889916.
Hernández A, Xamena N, Surrallés J, Sekaran C, Tokunaga H, Quinteros D, Creus A, Marcos R (januar 2008). "Role of the Met(287)Thr polymorphism in the AS3MT gene on the metabolic arsenic profile". Mutation Research. 637 (1–2): 80–92. doi:10.1016/j.mrfmmm.2007.07.004. PMID 17850829.
Lindberg AL, Kumar R, Goessler W, Thirumaran R, Gurzau E, Koppova K, Rudnai P, Leonardi G, Fletcher T, Vahter M (juli 2007). "Metabolism of low-dose inorganic arsenic in a central European population: influence of sex and genetic polymorphisms". Environmental Health Perspectives. 115 (7): 1081–6. doi:10.1289/ehp.10026. PMC 1913583. PMID 17637926.
Schläwicke Engström K, Broberg K, Concha G, Nermell B, Warholm M, Vahter M (april 2007). "Genetic polymorphisms influencing arsenic metabolism: evidence from Argentina". Environmental Health Perspectives. 115 (4): 599–605. doi:10.1289/ehp.9734. PMC 1852682. PMID 17450230.
Meza M, Gandolfi AJ, Klimecki WT (august 2007). "Developmental and genetic modulation of arsenic biotransformation: a gene by environment interaction?". Toxicology and Applied Pharmacology. 222 (3): 381–7. doi:10.1016/j.taap.2006.12.018. PMC 2040165. PMID 17306849.
Wood TC, Salavagionne OE, Mukherjee B, Wang L, Klumpp AF, Thomae BA, Eckloff BW, Schaid DJ, Wieben ED, Weinshilboum RM (mart 2006). "Human arsenic methyltransferase (AS3MT) pharmacogenetics: gene resequencing and functional genomics studies". The Journal of Biological Chemistry. 281 (11): 7364–73. doi:10.1074/jbc.M512227200. PMID 16407288.
Meza MM, Yu L, Rodriguez YY, Guild M, Thompson D, Gandolfi AJ, Klimecki WT (juni 2005). "Developmentally restricted genetic determinants of human arsenic metabolism: association between urinary methylated arsenic and CYT19 polymorphisms in children". Environmental Health Perspectives. 113 (6): 775–81. doi:10.1289/ehp.7780. PMC 1257606. PMID 15929903.
Li J, Waters SB, Drobna Z, Devesa V, Styblo M, Thomas DJ (april 2005). "Arsenic (+3 oxidation state) methyltransferase and the inorganic arsenic methylation phenotype". Toxicology and Applied Pharmacology. 204 (2): 164–9. doi:10.1016/j.taap.2004.12.002. PMID 15808521.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (oktobar 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (januar 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

Vanjski linkovi

Lokacija ljudskog genoma AS3MT i stranica sa detaljima o genu AS3MT u UCSC Genome Browseru.

Šablon:Jednougljične transferaze

Portal Biologija

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000214435 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000003559 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11790780-5] Lin S, Shi Q, Nix FB, Styblo M, Beck MA, Herbin-Davis KM, Hall LL, Simeonsson JB, Thomas DJ (mart 2002). "A novel S-adenosyl-L-methionine:arsenic(III) methyltransferase from rat liver cytosol". The Journal of Biological Chemistry. 277 (13): 10795–803. doi:10.1074/jbc.M110246200. PMID 11790780.

[entrez-6] "Entrez Gene: AS3MT arsenic (+3 oxidation state) methyltransferase".

[UniProt-7] "UniProt, Q9HBK9". Pristupljeno 30. 8. 2021.

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p r u Enzimi
Teme	Aktivno mjesto Alosterna regulacija Difuzijski limitirani enzim EC broj Enzimska kataliza Inhibicija enzimskih reakcija Kinetika enzima Koenzim Kooperativnost Lineweaver–Burkov dijagram Michaelis–Mentenova kinetika Mjesto vezanja Spisak enzima
Tipovi	EC1 Oksidoreduktaze/spisak EC2 Transferaze/spisak EC3 Hidrolaze/spisak EC4 Lijaze/spisak EC5 Izomeraze/spisak EC6 Ligaze/spisak

AS3MT

Aminokiselinska sekvenca

Reference

Dopunska literatura

Vanjski linkovi

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