BPIFB4
| BPIFB4 | |||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||||||||||||||||
| Aliasi | BPIFB4 | ||||||||||||||||||||||||
| Vanjski ID-jevi | OMIM: 615718 MGI: 2685852 HomoloGene: 66971 GeneCards: BPIFB4 | ||||||||||||||||||||||||
| |||||||||||||||||||||||||
| |||||||||||||||||||||||||
| Ortolozi | |||||||||||||||||||||||||
| Vrste | Čovjek | Miš | |||||||||||||||||||||||
| Entrez | |||||||||||||||||||||||||
| Ensembl | |||||||||||||||||||||||||
| UniProt | |||||||||||||||||||||||||
| RefSeq (mRNK) | |||||||||||||||||||||||||
| RefSeq (bjelančevina) | |||||||||||||||||||||||||
| Lokacija (UCSC) | Chr 20: 33.08 – 33.11 Mb | Chr 2: 153.78 – 153.81 Mb | |||||||||||||||||||||||
| PubMed pretraga | [3] | [4] | |||||||||||||||||||||||
| Wikipodaci | |||||||||||||||||||||||||
| |||||||||||||||||||||||||
BPI nabor koji sadrži člana 4 porodicu B je protein koji kod ljudi kodiran genom BPIFB4.[5]
BPIFB4 ima sličnost u sekvenci s antimikrobnim peptidima koji vežu lipofilne supstrate i pružaju odbranu od od gram-negativnih bakterija.[6]
Pretragom baze podataka o mirisnom epitelu EST za sekvence slične pacovskim Ry2g5, nakon čega slijedi PCR biblioteke cDNK ljudskog ]]fetus]]nog mozga, klonirali su BPIFB4, koji su nazvali RY2G5. Izvedeni protein s 575 aminokiselina ima područje bogato leucinom, dva konzervirana cisteina i tri konzervirana prolina. Dijeli 90% aminokiselinskog identiteta s 462-aminokiselinskim mišjim ortologom. Northern blot analiza 16 ljudskih tkiva otkrila je transkript RY2G5 od 2,2 kb samo u leukocitima periferne krvi. RT-PCR analiza 14 tkiva miša otkrila je ekspresiju Ry2g5 samo u mirisnom epitelu. Fluorescentno označeni ljudski RY2G5 eksprimiran je u distribuciji tačaka citoplazme u transficiranim HEK293 ćelijama. Utvrdiili su da gen BPIFB4 sadrži 15 kodirajućih egzona i obuhvata približno 28,8 kb.
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000186191 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000074665 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: BPI fold containing family B, member 4".
- ^ Andrault, J.-B., Gaillard, I., Giorgi, D., Rouquier, S. Expansion of the BPI family by duplication on human chromosome 20: characterization of the RY gene cluster in 20q11.21 encoding olfactory transporters/antimicrobial-like peptides. Genomics 82: 172-184, 2003. [PubMed: 12837268]
Dopunska literatura
- Bingle CD, Craven CJ (august 2003). "Comparative analysis of the PLUNC (palate, lung and nasal epithelium clone) protein families". Biochemical Society Transactions. 31 (Pt 4): 806–9. doi:10.1042/bst0310806. PMID 12887310.
- Andrault JB, Gaillard I, Giorgi D, Rouquier S (august 2003). "Expansion of the BPI family by duplication on human chromosome 20: characterization of the RY gene cluster in 20q11.21 encoding olfactory transporters/antimicrobial-like peptides". Genomics. 82 (2): 172–84. doi:10.1016/S0888-7543(03)00102-2. PMID 12837268.
- Bingle CD, Seal RL, Craven CJ (august 2011). "Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a subfamily of the BPI fold-containing superfamily". Biochemical Society Transactions. 39 (4): 977–83. doi:10.1042/BST0390977. PMC 3196848. PMID 21787333.
- Bingle CD, Craven CJ (april 2002). "PLUNC: a novel family of candidate host defence proteins expressed in the upper airways and nasopharynx". Human Molecular Genetics. 11 (8): 937–43. doi:10.1093/hmg/11.8.937. PMID 11971875.
Content Disclaimer
Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.
- The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
- There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
- It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
- Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
- Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.
