CCL16
| Hemokinski (C-C motivni) ligand 16 | |||||||
|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||
| Simbol | CCL16 | ||||||
| Alt. simboli | SCYA16, NCC-4, SCYL4, LEC, HCC-4, LMC, LCC-1, CKb12, Mtn-1 | ||||||
| NCBI gen | 6360 | ||||||
| HGNC | 10614 | ||||||
| OMIM | 601394 | ||||||
| RefSeq | NM_004590 | ||||||
| UniProt | O15467 | ||||||
| Ostali podaci | |||||||
| Lokus | Hrom. 17 q11.2 | ||||||
| |||||||
Hemokinski (C-C motivni) ligand 16 (CCL16) jest mali citokin koji pripada porodici CC hemokina i poznat je pod nekoliko pseudonima, uključujući hemokine koji eksprimira jetra (LEC) i monotaktin-1 (MTN-1). Ovaj hemokin se ekspimira u jetri, timusu i slezeni i hemoatraktivan je za monocite i limfocite.[3] Ćelijska ekspresija CCL16 može se snažno inducirati u monocitima pomoću InterleukinIL-10, IFN-γ i bakterijsi lipopolisaharid. Njegov gen nalazi se na hromosomu 17, kod ljudi, među skupinom ostalih CC-hemokina.[4] CCL16 izaziva učinke na ćelije interakcijom sa hemokinskim receptorima na površini ćelije, kao što su CCR1, CCR2, CCR5 i CCR8.[5][6]
C-C motiv hemokinskih liganada 16 pronađen je u visokim nivoima u ljudskoj krvnoj plazmi.[7] CCL16 može biti koristan za promet eozinofila. Utvrđeno je da ovaj ligand ima funkcionalni afinitet za H4 receptore koji se eksprimiraju u eozinofilima i mastocitima.[7] Pokazano je da ovaj hemokin suzbija brzu proliferaciju mijeloidnih progenitornih ćelija.[8]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 120 aminokiselina, a molekulska težina 13.600 Da.[9].
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MKVSEAALSL | LVLILIITSA | SRSQPKVPEW | VNTPSTCCLK | YYEKVLPRRL | ||||
| VVGYRKALNC | HLPAIIFVTK | RNREVCTNPN | DDWVQEYIKD | PNLPLLPTRN | ||||
| LSTVKIITAK | NGQPQLLNSQ |
- Simboli
C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin
Reference
- ^ a b c ENSG00000275095 GRCh38: Ensembl release 89: ENSG00000275152, ENSG00000275095 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Youn BS, Zhang S, Broxmeyer HE, Antol K, Fraser MJ, Hangoc G, Kwon BS (juni 1998). "Isolation and characterization of LMC, a novel lymphocyte and monocyte chemoattractant human CC chemokine, with myelosuppressive activity". Biochemical and Biophysical Research Communications. 247 (2): 217–22. doi:10.1006/bbrc.1998.8762. PMID 9642106.
- ^ Nomiyama H, Fukuda S, Iio M, Tanase S, Miura R, Yoshie O (mart 1999). "Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, HCC-1, LEC, and RANTES". Journal of Interferon & Cytokine Research. 19 (3): 227–34. doi:10.1089/107999099314153. PMID 10213461.
- ^ Nomiyama H, Hieshima K, Nakayama T, Sakaguchi T, Fujisawa R, Tanase S, Nishiura H, Matsuno K, Takamori H, Tabira Y, Yamamoto T, Miura R, Yoshie O (august 2001). "Human CC chemokine liver-expressed chemokine/CCL16 is a functional ligand for CCR1, CCR2 and CCR5, and constitutively expressed by hepatocytes". International Immunology. 13 (8): 1021–9. doi:10.1093/intimm/13.8.1021. PMID 11470772.
- ^ Howard OM, Dong HF, Shirakawa AK, Oppenheim JJ (august 2000). "LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8". Blood. 96 (3): 840–5. doi:10.1182/blood.V96.3.840. PMID 10910894.
- ^ a b Nakayama T, Kato Y, Hieshima K, Nagakubo D, Kunori Y, Fujisawa T, Yoshie O (august 2004). "Liver-expressed chemokine/CC chemokine ligand 16 attracts eosinophils by interacting with histamine H4 receptor". Journal of Immunology. 173 (3): 2078–83. doi:10.4049/jimmunol.173.3.2078. PMID 15265943.
- ^ "CCL16 C-C Motif Chemokine Ligand 16 [Homo Sapiens (Human)] Gene". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "UniProt, O15467". Pristupljeno 28. 6. 2021.
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