CPLX2
Kompleksin-2 jest protein koji je kod ljudi kodiran genom CPLX2.[5][6][7]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 134 aminokiseline, а molekulska težina 15.394 Da.[8]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MDFVMKQALG | GATKDMGKML | GGEEEKDPDA | QKKEEERQEA | LRQQEEERKA | ||||
| KHARMEAERE | KVRQQIRDKY | GLKKKEEKEA | EEKAALEQPC | EGSLTRPKKA | ||||
| IPAGCGDEEE | EEEESILDTV | LKYLPGPLQD | MFKK |
Funkcija
Proteini kodirani genimaa porodice kompleksin/sinafin su citosolni proteini koji funkcioniraju u egzocitozi sinapsnih vezikula. Ovi proteini vežu sintaksin, dio SNAP receptora. Proteinski proizvod ovog gena veže se za kompleks receptora SNAP -a i ometa ga, omogućavajući oslobađanje predajnika. Za ovaj gen pronađene su dvije varijante transkripta koje kodiraju isti protein.[7]
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000145920 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025867 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ McMahon HT, Missler M, Li C, Sudhof TC (Nov 1995). "Complexins: cytosolic proteins that regulate SNAP receptor function". Cell. 83 (1): 111–9. doi:10.1016/0092-8674(95)90239-2. PMID 7553862. S2CID 675343.
- ^ Raevskaya NM, Dergunova LV, Vladychenskaya IP, Stavchansky VV, Oborina MV, Poltaraus AB, Limborska SA (Sep 2005). "Structural organization of the human complexin 2 gene (CPLX2) and aspects of its functional activity". Gene. 359: 127–37. doi:10.1016/j.gene.2005.07.005. PMID 16162394.
- ^ a b "Entrez Gene: CPLX2 complexin 2".
- ^ "UniProt, Q6PUV4" (jezik: engleski). Pristupljeno 13. 10. 2021.
Dopunska literatura
- Abe T (2002). "[The mechanism of neurotransmitter release: role of synaphin/complexin in synaptic vesicle exocytosis]". Tanpakushitsu Kakusan Koso. 47 (7): 794–800. PMID 12058476.
- Christensen VL, Johnston NP (1978). "Effect of time of day of insemination and the position of the egg in the oviduct on the fertility of turkeys". Poult. Sci. 56 (2): 458–62. doi:10.3382/ps.0560458. PMID 605033.
- Morgans CW, Brandstätter JH, Kellerman J, et al. (1996). "A SNARE complex containing syntaxin 3 is present in ribbon synapses of the retina". J. Neurosci. 16 (21): 6713–21. doi:10.1523/JNEUROSCI.16-21-06713.1996. PMC 6579260. PMID 8824312.
- Harrison PJ, Eastwood SL (1998). "Preferential involvement of excitatory neurons in medial temporal lobe in schizophrenia". Lancet. 352 (9141): 1669–73. doi:10.1016/S0140-6736(98)03341-8. PMID 9853440. S2CID 45239545.
- Ishizuka T, Saisu H, Odani S, et al. (1999). "Distinct regional distribution in the brain of messenger RNAs for the two isoforms of synaphin associated with the docking/fusion complex". Neuroscience. 88 (1): 295–306. doi:10.1016/S0306-4522(98)00223-1. PMID 10051208. S2CID 46636775.
- Yamada M, Saisu H, Ishizuka T, et al. (1999). "Immunohistochemical distribution of the two isoforms of synaphin/complexin involved in neurotransmitter release: localization at the distinct central nervous system regions and synaptic types". Neuroscience. 93 (1): 7–18. doi:10.1016/S0306-4522(99)00104-9. PMID 10430466. S2CID 21532356.
- Pabst S, Hazzard JW, Antonin W, et al. (2000). "Selective interaction of complexin with the neuronal SNARE complex. Determination of the binding regions". J. Biol. Chem. 275 (26): 19808–18. doi:10.1074/jbc.M002571200. PMID 10777504.
- Eastwood SL, Cotter D, Harrison PJ (2001). "Cerebellar synaptic protein expression in schizophrenia". Neuroscience. 105 (1): 219–29. doi:10.1016/S0306-4522(01)00141-5. PMID 11483314. S2CID 34257327.
- Eastwood SL, Harrison PJ (2001). "Synaptic pathology in the anterior cingulate cortex in schizophrenia and mood disorders. A review and a Western blot study of synaptophysin, GAP-43 and the complexins". Brain Res. Bull. 55 (5): 569–78. doi:10.1016/S0361-9230(01)00530-5. PMID 11576753. S2CID 23012653.
- Pabst S, Margittai M, Vainius D, et al. (2002). "Rapid and selective binding to the synaptic SNARE complex suggests a modulatory role of complexins in neuroexocytosis". J. Biol. Chem. 277 (10): 7838–48. doi:10.1074/jbc.M109507200. PMID 11751907.
- Sawada K, Young CE, Barr AM, et al. (2002). "Altered immunoreactivity of complexin protein in prefrontal cortex in severe mental illness". Mol. Psychiatry. 7 (5): 484–92. doi:10.1038/sj.mp.4000978. PMID 12082566.
- Hu K, Carroll J, Rickman C, Davletov B (2003). "Action of complexin on SNARE complex". J. Biol. Chem. 277 (44): 41652–6. doi:10.1074/jbc.M205044200. PMID 12200427.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Edwardson JM, Wang CT, Gong B, et al. (2003). "Expression of mutant huntingtin blocks exocytosis in PC12 cells by depletion of complexin II". J. Biol. Chem. 278 (33): 30849–53. doi:10.1074/jbc.M304615200. PMID 12807877.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Eastwood SL, Harrison PJ (2005). "Decreased expression of vesicular glutamate transporter 1 and complexin II mRNAs in schizophrenia: further evidence for a synaptic pathology affecting glutamate neurons". Schizophr. Res. 73 (2–3): 159–72. doi:10.1016/j.schres.2004.05.010. PMID 15653259. S2CID 2335413.
- DiProspero NA, Chen EY, Charles V, et al. (2005). "Early changes in Huntington's disease patient brains involve alterations in cytoskeletal and synaptic elements". J. Neurocytol. 33 (5): 517–33. doi:10.1007/s11068-004-0514-8. PMID 15906159. S2CID 20082165.
Vanjski linkovi
- Lokacija ljudskog genoma CPLX2 i stranica sa detaljima o genu CPLX2 u UCSC Genome Browseru.
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