CPSF7
Podjedinica 7 faktora specifičnosti cijepanja i poliadenilacije je protein koji je kod ljudi kodiran genom CPSF7.[5][6]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 471 aminokiselina, a molekulska težina 52.050 Da.[7]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MSEGVDLIDI | YADEEFNQDP | EFNNTDQIDL | YDDVLTATSQ | PSDDRSSSTE | ||||
| PPPPVRQEPS | PKPNNKTPAI | LYTYSGLRNR | RAAVYVGSFS | WWTTDQQLIQ | ||||
| VIRSIGVYDV | VELKFAENRA | NGQSKGYAEV | VVASENSVHK | LLELLPGKVL | ||||
| NGEKVDVRPA | TRQNLSQFEA | QARKRECVRV | PRGGIPPRAH | SRDSSDSADG | ||||
| RATPSENLVP | SSARVDKPPS | VLPYFNRPPS | ALPLMGLPPP | PIPPPPPLSS | ||||
| SFGVPPPPPG | IHYQHLMPPP | PRLPPHLAVP | PPGAIPPALH | LNPAFFPPPN | ||||
| ATVGPPPDTY | MKASAPYNHH | GSRDSGPPPS | TVSEAEFEDI | MKRNRAISSS | ||||
| AISKAVSGAS | AGDYSDAIET | LLTAIAVIKQ | SRVANDERCR | VLISSLKDCL | ||||
| HGIEAKSYSV | GASGSSSRKR | HRSRERSPSR | SRESSRRHRD | LLHNEDRHDD | ||||
| YFQERNREHE | RHRDRERDRH | H |
Funkcija
CPSF7, takođe poznat i kao CFIm59, je faktor cijepanja dva blisko povezana proteinska kompleksA u 3' netranslatiranoj regiji molekuli novosintetizirane pre-iRNK, koja se koristi u transkripciji gena.[8] CPSF7 je jedan od tri faktora specifičnosti cijepanja i poliadenilacije (CPSF), a druga dva su CFIm25 (ili CPSF5/NUDT21) i CFIm68 (ili CPSF6).
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000149532 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034820 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (decembar 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- ^ "Entrez Gene: FLJ12529 pre-mRNA cleavage factor I, 59 kDa subunit".
- ^ "UniProt, Q8N684". Pristupljeno 20. 8. 2021.
- ^ Hardy JG, Norbury CJ (august 2016). "Cleavage factor Im (CFIm) as a regulator of alternative polyadenylation". Biochemical Society Transactions. 44 (4): 1051–7. doi:10.1042/BST20160078. PMID 27528751.
Dopunska literatura
- Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (novembar 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
- Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (maj 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
- Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (maj 2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Analytical Chemistry. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
- Rüegsegger U, Beyer K, Keller W (mart 1996). "Purification and characterization of human cleavage factor Im involved in the 3' end processing of messenger RNA precursors". The Journal of Biological Chemistry. 271 (11): 6107–13. doi:10.1074/jbc.271.11.6107. PMID 8626397.
Content Disclaimer
Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.
- The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
- There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
- It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
- Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
- Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.
Index:
pl ar de en es fr it arz nl ja pt ceb sv uk vi war zh ru af ast az bg zh-min-nan bn be ca cs cy da et el eo eu fa gl ko hi hr id he ka la lv lt hu mk ms min no nn ce uz kk ro simple sk sl sr sh fi ta tt th tg azb tr ur zh-yue hy my ace als am an hyw ban bjn map-bms ba be-tarask bcl bpy bar bs br cv nv eml hif fo fy ga gd gu hak ha hsb io ig ilo ia ie os is jv kn ht ku ckb ky mrj lb lij li lmo mai mg ml zh-classical mr xmf mzn cdo mn nap new ne frr oc mhr or as pa pnb ps pms nds crh qu sa sah sco sq scn si sd szl su sw tl shn te bug vec vo wa wuu yi yo diq bat-smg zu lad kbd ang smn ab roa-rup frp arc gn av ay bh bi bo bxr cbk-zam co za dag ary se pdc dv dsb myv ext fur gv gag inh ki glk gan guw xal haw rw kbp pam csb kw km kv koi kg gom ks gcr lo lbe ltg lez nia ln jbo lg mt mi tw mwl mdf mnw nqo fj nah na nds-nl nrm nov om pi pag pap pfl pcd krc kaa ksh rm rue sm sat sc trv stq nso sn cu so srn kab roa-tara tet tpi to chr tum tk tyv udm ug vep fiu-vro vls wo xh zea ty ak bm ch ny ee ff got iu ik kl mad cr pih ami pwn pnt dz rmy rn sg st tn ss ti din chy ts kcg ve
