CREG1
Protein CREG1 (ćelijski represor E1A-stimuliranih gena 1) jest protein koji je kod ljudi kodiran genom CREG1 sa hromosoma 1.[5][6]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 220 aminokiselina, a molekulska težina 24.075 Da.[7]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MAGLSRGSAR | ALLAALLAST | LLALLVSPAR | GRGGRDHGDW | DEASRLPPLP | ||||
| PREDAARVAR | FVTHVSDWGA | LATISTLEAV | RGRPFADVLS | LSDGPPGAGS | ||||
| GVPYFYLSPL | QLSVSNLQEN | PYATLTMTLA | QTNFCKKHGF | DPQSPLCVHI | ||||
| MLSGTVTKVN | ETEMDIAKHS | LFIRHPEMKT | WPSSHNWFFA | KLNITNIWVL | ||||
| DYFGGPKIVT | PEEYYNVTVQ |
Funkcija
Protein adenovirusa E1A istovremeno aktivira i potiskuje ekspresiju gena, kako bi promovirao ćelijsku proliferaciju i inhibirao diferencijaciju. Protein kodiran ovim genom antagonizira transkripcijsku aktivaciju i ćelijsku transformaciju pomoću E1A. Ovaj protein dijeli ograničenu sličnost sekvence sa E1A i vezuje se za opći transkripcijski faktor TBP i tumorski supresor pRb in vitro. Ovaj gen može doprinijeti transkripcijskoj kontroli rasta i ćelijske diferencijacije.[6]
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000143162 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040713 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Veal E, Eisenstein M, Tseng ZH, Gill G (Sep 1998). "A Cellular Repressor of E1A-Stimulated Genes That Inhibits Activation by E2F". Mol Cell Biol. 18 (9): 5032–41. doi:10.1128/mcb.18.9.5032. PMC 109088. PMID 9710587.
- ^ a b "Entrez Gene: CREG1 cellular repressor of E1A-stimulated genes 1".
- ^ "UniProt, O75629" (jezik: en.). Pristupljeno 9. 12. 2021.CS1 održavanje: nepoznati jezik (link)
Dopunska literatura
- Veal E, Groisman R, Eisenstein M, Gill G (2000). "The secreted glycoprotein CREG enhances differentiation of NTERA-2 human embryonal carcinoma cells". Oncogene. 19 (17): 2120–8. doi:10.1038/sj.onc.1203529. PMID 10815803.
- Jiang LQ, Wen SJ, Wang HY, Chen LY (2003). "Screening the proteins that interact with calpain in a human heart cDNA library using a yeast two-hybrid system". Hypertens. Res. 25 (4): 647–52. doi:10.1291/hypres.25.647. PMID 12358155.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Di Bacco A, Gill G (2003). "The secreted glycoprotein CREG inhibits cell growth dependent on the mannose-6-phosphate/insulin-like growth factor II receptor". Oncogene. 22 (35): 5436–45. doi:10.1038/sj.onc.1206670. PMID 12934103.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
- Sacher M, Di Bacco A, Lunin VV, et al. (2006). "The crystal structure of CREG, a secreted glycoprotein involved in cellular growth and differentiation". Proc. Natl. Acad. Sci. U.S.A. 102 (51): 18326–31. doi:10.1073/pnas.0505071102. PMC 1317909. PMID 16344469.
- Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Vanjski linkovi
- Lokacija ljudskog genoma CREG1 i stranica sa detaljima o genu CREG1 u UCSC Genome Browseru.
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Index:
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