DACH2
Jazavčarski homolog 2 je protein koji je kod ljudi kodiran genom DACH2.[5]
Funkcija
Ovaj gen je jedan od dva gena koji kodiraju protein jazavčarskolikom proteinu Drosophila , faktor transkripcije uključenom u određivanje sudbine ćelija u oku, udu i genitalnom disku muhe. Kodirani protein sadrži dva karakteristična takva domena: N-krajev domen odgovoran za vezanje DNK i C-krajev domen odgovoran za interakcije protein-protein. Ovaj gen se nalazi na X hromosomu i podložan je inaktivaciji metilacijom DNK. Kodirani protein može biti uključen u regulaciju organogeneze i miogeneze i može imati ulogu u preranom otkazivanju jajnika.
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000126733 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025592 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Za ovaj gen pronađeno je više varijanti transkripta koji kodiraju različite izoforme. "Entrez Gene: Dachshund homolog 2 (Drosophila)". Pristupljeno 15. 4. 2012.
Dopunska literatura
- Bione S, Rizzolio F, Sala C, Ricotti R, Goegan M, Manzini MC, Battaglia R, Marozzi A, Vegetti W, Dalprà L, Crosignani PG, Ginelli E, Nappi R, Bernabini S, Bruni V, Torricelli F, Zuffardi O, Toniolo D (Dec 2004). "Mutation analysis of two candidate genes for premature ovarian failure, DACH2 and POF1B". Human Reproduction. 19 (12): 2759–66. doi:10.1093/humrep/deh502. PMID 15459172.
- Poulin F, Nobrega MA, Plajzer-Frick I, Holt A, Afzal V, Rubin EM, Pennacchio LA (Jun 2005). "In vivo characterization of a vertebrate ultraconserved enhancer" (Submitted manuscript). Genomics. 85 (6): 774–81. doi:10.1016/j.ygeno.2005.03.003. PMID 15885503.
- Davis RJ, Shen W, Sandler YI, Heanue TA, Mardon G (Apr 2001). "Characterization of mouse Dach2, a homologue of Drosophila dachshund". Mechanisms of Development. 102 (1–2): 169–79. doi:10.1016/s0925-4773(01)00307-0. PMID 11287190.
- Aikawa Y, Nguyen LA, Isono K, Takakura N, Tagata Y, Schmitz ML, Koseki H, Kitabayashi I (Sep 2006). "Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation". The EMBO Journal. 25 (17): 3955–65. doi:10.1038/sj.emboj.7601273. PMC 1560355. PMID 16917507.
- Prueitt RL, Chen H, Barnes RI, Zinn AR (2002). "Most X;autosome translocations associated with premature ovarian failure do not interrupt X-linked genes". Cytogenetic and Genome Research. 97 (1–2): 32–8. doi:10.1159/000064052. PMID 12438735.
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