DNASE2
| DNASE2 | |||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||||||||||||||||
| Aliasi | DNASE2 | ||||||||||||||||||||||||
| Vanjski ID-jevi | OMIM: 126350 MGI: 1329019 HomoloGene: 68179 GeneCards: DNASE2 | ||||||||||||||||||||||||
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| Ortolozi | |||||||||||||||||||||||||
| Vrste | Čovjek | Miš | |||||||||||||||||||||||
| Entrez | |||||||||||||||||||||||||
| Ensembl | |||||||||||||||||||||||||
| UniProt | |||||||||||||||||||||||||
| RefSeq (mRNK) | |||||||||||||||||||||||||
| RefSeq (bjelančevina) | |||||||||||||||||||||||||
| Lokacija (UCSC) | Chr 19: 12.88 – 12.88 Mb | n/a | |||||||||||||||||||||||
| PubMed pretraga | [2] | [3] | |||||||||||||||||||||||
| Wikipodaci | |||||||||||||||||||||||||
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Lizosomska dezoksiribonukleaza II je protein koji je kod ljudi kodiran genom DNASE2.[4]
Aminokiselinska sekvenca
- Simboli
C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MIPLLLAALL | CVPAGALTCY | GDSGQPVDWF | VVYKLPALRG | SGEAAQRGLQ | ||||
| YKYLDESSGG | WRDGRALINS | PEGAVGRSLQ | PLYRSNTSQL | AFLLYNDQPP | ||||
| QPSKAQDSSM | RGHTKGVLLL | DHDGGFWLVH | SVPNFPPPAS | SAAYSWPHSA | ||||
| CTYGQTLLCV | SFPFAQFSKM | GKQLTYTYPW | VYNYQLEGIF | AQEFPDLENV | ||||
| VKGHHVSQEP | WNSSITLTSQ | AGAVFQSFAK | FSKFGDDLYS | GWLAAALGTN | ||||
| LQVQFWHKTV | GILPSNCSDI | WQVLNVNQIA | FPGPAGPSFN | STEDHSKWCV | ||||
| SPKGPWTCVG | DMNRNQGEEQ | RGGGTLCAQL | PALWKAFQPL | VKNYQPCNGM | ||||
| ARKPSRAYKI |
Funkcija
Ovaj gen kodira člana porodice DNaza. Protein koji se nalazi u lizosomima, hidrolizira DNK u kiselim uslovima i posreduje u njenom raspadanju tokom eritropoeze i apoptoze.
Okarakterizirana su dva kodominantna alelA, DNASE2 * L (niska aktivnost) i DNASE2 * H (visoka aktivnost), koji se razlikuju PO jednom nukleotidU u promotorskoj regiji. U ovom TRANSKRIPTU zastupljen je alel DNASE2 * H.
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000105612 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Deoxyribonuclease II, lysosomal". Pristupljeno 7. 9. 2016.
Dopunska literatura
- Chou SF, Chen HL, Lu SC (2002). "Up-regulation of human deoxyribonuclease II gene expression during myelomonocytic differentiation of HL-60 and THP-1 cells". Biochem. Biophys. Res. Commun. 296 (1): 48–53. doi:10.1016/s0006-291x(02)00835-5. PMID 12147225.
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