GGT6
Gama-glutamiltransferaza 6 je enzimski protein koji je kod ljudi kodiran genom GGT6.[5]
Dužina polipeptidnog lanca je 493 aminokiseline, sa molekulskom težinom od 50.509[6].
Aminokiselinska sekvenca
- Simboli
C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MERAEEPVVY | QKLLPWEPSL | ESEEEVEEEE | TSEALVLNPR | RHQDSSRNKA | ||||
| GGLPGTWARV | VAALLLLAVG | CSLAVRQLQN | QGRSTGSLGS | VAPPPGGHSH | ||||
| GPGVYHHGAI | ISPAGRELLV | AGGNVVDAGV | GAALCLAVVH | PHATGLGAMF | ||||
| WGLFHDSSSG | NSTALTSGPA | QTLAPGLGLP | AALPTLHLLH | ARFGRLPWPR | ||||
| LLVGPTTLAQ | EGFLVDTPLA | RALVARGTEG | LCPLLCHADG | TPLGAGARAT | ||||
| NPQLAAVLRS | AALAPTSDLA | GDALLSLLAG | DLGVEVPSAV | PRPTLEPAEQ | ||||
| LPVPQGILFT | TPSPSAGPEL | LALLEAALRS | GAPIPDPCPP | FLQTAVSPES | ||||
| SALAAVDSSG | SVLLLTSSLN | CSFGSAHLSP | STGVLLSNLV | AKSTTSAWAC | ||||
| PLILRGSLDD | TEADVLGLVA | SGTPDVARAM | THTLLRHLAA | RPPTQAQHQH | ||||
| QGQQEPTEHP | STCGQGTLLQ | VAAHTEHAHV | SSVPHACCPF | QGF |
Funkcija
GGT6 pripada porodici gena gama-glutamiltransferaza (GGT; EC 2.3.2.2). GGT je vezana za membranu vanćelijski enzim koji cijepa gama-glutamil peptidne veze u glutationu i drugim peptidima i prenosi gama-glutamilni dio na akceptore. GGT je također ključna za homeostazu glutationa jer pruža supstrate za sintezu glutationa (Heisterkamp et al., 2008 [PubMed 18357469]).
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000167741 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040471 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Gamma-glutamyltransferase 6". Pristupljeno 11. 3. 2016.
- ^ "UniProt, Q6P531". Pristupljeno 12. 9. 2017.
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