GSTM1
Glutation S-transferaza Mu 1 jest glutation S-transferaza, enzim koji je kod ljudi kodiran genom GSTM1 sa hromosoma 1.
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 218 aminokiselina, a molekulska težina 25.712 Da.[5]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MPMILGYWDI | RGLAHAIRLL | LEYTDSSYEE | KKYTMGDAPD | YDRSQWLNEK | ||||
| FKLGLDFPNL | PYLIDGAHKI | TQSNAILCYI | ARKHNLCGET | EEEKIRVDIL | ||||
| ENQTMDNHMQ | LGMICYNPEF | EKLKPKYLEE | LPEKLKLYSE | FLGKRPWFAG | ||||
| NKITFVDFLV | YDVLDLHRIF | EPKCLDAFPN | LKDFISRFEG | LEKISAYMKS | ||||
| SRFLPRPVFS | KMAVWGNK |
Funkcija
Citosolni i membranski oblici glutation S-transferaze kodirani su od putem dvije različite porodice supergena. Do sada je identifikovano osam različitih klasa rastvorljivih citoplazmatskih sisarskih glutation S-transferaza: alfa, kapa, mu, omega, pi, sigma, teta i zeta. Ovaj gen kodira citoplazmatsku glutation S-transferazu koja pripada mu klasi. Mu klasa enzima funkcionira u detoksikaciji elektrofilnih spojeva, uključujući karcinogene, terapeutske lijekove, otrove iz okoline i proizvode oksidativnih stresova, konjugacije sa glutationom.
Geni koji kodiraju mu klasu enzima su organizovani u genski klaster na hromosomskoj regiji 1p13.3 i poznato je da su veoma polimorfni. Ove genetičke varijacije mogu promijeniti osjetljivost osoba na karcinogene i toksine, kao i uticati na toksičnost i djelotvornost određenih lijekova. Nulta mutacija ove klase mu gena povezana je sa povećanjem broja kancera, vjerovatno zbog povećane osjetljivosti na toksine i karcinogene iz okoline. Varijantama transkripta ovog gena kodirano je više izoformi proteina.[6]
Također pogledajte
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000134184 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040562 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "UniProt, P09488" (jezik: eng.). Pristupljeno 28. 11. 2021.CS1 održavanje: nepoznati jezik (link)
- ^ "Entrez Gene: GSTM1 glutathione S-transferase M1".
Dopunska literatura
- Engel LS, Taioli E, Pfeiffer R, Garcia-Closas M, Marcus PM, Lan Q, et al. (juli 2002). "Pooled analysis and meta-analysis of glutathione S-transferase M1 and bladder cancer: a HuGE review". American Journal of Epidemiology. 156 (2): 95–109. doi:10.1093/aje/kwf018. PMID 12117698.
- Navarro SL, Chang JL, Peterson S, Chen C, King IB, Schwarz Y, Li SS, Li L, Potter JD, Lampe JW (novembar 2009). "Modulation of human serum glutathione S-transferase A1/2 concentration by cruciferous vegetables in a controlled feeding study is influenced by GSTM1 and GSTT1 genotypes". Cancer Epidemiology, Biomarkers & Prevention. 18 (11): 2974–8. doi:10.1158/1055-9965.EPI-09-0701. PMC 2777676. PMID 19900941.
Vanjski linkovi
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Glutathione S-transferase Mu 1
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