HDHD1A
Halokiselinski dehalogenazoliki hidrolazni domen-sadržavajući protein 1A je enzim koji je kod ljudi kodiran genom HDHD1A.[5][6][7] Kodira pseudouridin-5'-fosfatazu, ali može primiti i druge fosforilirane metabolite s nižim afinitetom.[8][9]
Funkcije
- Molekulske
• pseudouridin 5'-fosfatazna aktivnost • aktivnost hidrolaze • vezivanje metalnih jona • aktivnost fosfataze • molekulska funkcija • vezivanje iona magnezija
- Ćelijska komponenta
• citosol • citoplazma
- Biološki proces:
• spašavanje pirimidin nukleozida • metabolizam • metabolički proces nukleotida • defosforilacija
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000130021 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000048875 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Salido EC, Yen PH, Koprivnikar K, Yu LC, Shapiro LJ (februar 1992). "The human enamel protein gene amelogenin is expressed from both the X and the Y chromosomes". American Journal of Human Genetics. 50 (2): 303–16. PMC 1682460. PMID 1734713.
- ^ Yen PH, Ellison J, Salido EC, Mohandas T, Shapiro L (april 1992). "Isolation of a new gene from the distal short arm of the human X chromosome that escapes X-inactivation". Human Molecular Genetics. 1 (1): 47–52. doi:10.1093/hmg/1.1.47. PMID 1284467.
- ^ "Entrez Gene: HDHD1A haloacid dehalogenase-like hydrolase domain containing 1A".
- ^ Preumont A, Rzem R, Vertommen D, Van Schaftingen E (oktobar 2010). "HDHD1, which is often deleted in X-linked ichthyosis, encodes a pseudouridine-5'-phosphatase". The Biochemical Journal. 431 (2): 237–44. doi:10.1042/bj20100174. PMID 20722631.
- ^ Defenouillère Q, Verraes A, Laussel C, Friedrich A, Schacherer J, Léon S (septembar 2019). "The induction of HAD-like phosphatases by multiple signaling pathways confers resistance to the metabolic inhibitor 2-deoxyglucose". Science Signaling. 12 (597): eaaw8000. doi:10.1126/scisignal.aaw8000. PMID 31481524.
Dopunska literatura
- Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (januar 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Suzuki Y, Tsunoda T, Sese J, Taira H, Mizushima-Sugano J, Hata H, et al. (maj 2001). "Identification and characterization of the potential promoter regions of 1031 kinds of human genes". Genome Research. 11 (5): 677–84. doi:10.1101/gr.gr-1640r. PMC 311086. PMID 11337467.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (oktobar 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Maruyama K, Sugano S (januar 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
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