HECT-domen
| HECT-domen (ubikvitin-transferaza) | |
|---|---|
 Struktura kompleksa e6ap-ubch7: uvid u put ubikvitinacije | |
| Identifikatori | |
| Simbol | HECT |
U molekulskoj biologiji, HECT-domen je proteinski domen koji se nalazi u ubikvitin-proteinskim ligazama. Naziv HECT dolazi od Homolog za E6-AP Carboxyl Terminus (C-terminal).[1] Proteini koji sadrže ovaj domen na C-terminalu uključuju ubikvitin-protein ligazu, koja reguliše ubikvitinaciju CDC25. Ubikvitin-proteinska ligaza prihvata ubikvitin od E2 ubikvitin-konjugirajućeg enzima u obliku tioestera, a zatim direktno prenosi ubikvitin na ciljane supstrate.
Za formiranje ubikvitin-tiolestera potreban je cisteinski ostatak. Protein 12, u interakciji sa ljudskim receptorom šhornona štitne žlijezde (TRIP12), koji također sadrži ovaj domen, komponenta je ATP-ovisne multipodjedinice proteina koji reaguje sa ligand vezujućim domenom receptora tiroidnog hormona. To bi mogla biti E3 ubikvitin-proteinska ligaza. Ljudska E6AP ubikvitin-proteinska ligaza međudjeluje sa E6 proteinom ljudskog papiloma virusa tipa 16 i ljudskim papiloma virusom tipa 18. E6/E6 -AP kompleks veže se i cilja na p53 tumor-supresorski protein za proteolizu posredovanu ubikvitinom.
Reference
- ^ Huibregtse JM, Scheffner M, Beaudenon S, Howley PM (mart 1995). "A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase". Proc. Natl. Acad. Sci. U.S.A. 92 (7): 2563–7. Bibcode:1995PNAS...92.2563H. doi:10.1073/pnas.92.7.2563. PMC 42258. PMID 7708685.
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