HIST1H4A
Histon H4 jest protein koji je kod ljudi kodiran genom HIST1H4A sa hromosoma 6.[5][6][7]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 103 aminokiseline, a molekulska težina 11.367 Da.[7]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MSGRGKGGKG | LGKGGAKRHR | KVLRDNIQGI | TKPAIRRLAR | RGGVKRISGL | ||||
| IYEETRGVLK | VFLENVIRDA | VTYTEHAKRK | TVTAMDVVYA | LKRQGRTLYG | ||||
| FGG |
Funkcija
Histoni su osnovni jedarni proteini koji su odgovorni za nukleosomsku strukturu hromosomskog vlakna u eukariotima. Dvije molekule svakog od četiri jezgra histona (H2A, H2B, H3 i H4) formiraju oktamer, oko kojeg je oko 146 bp DNK omotano u ponavljajuće jedinice, zvane nukleosomi. Linkerski histon, H1, stupa u interakciju sa linkerom DNK, između nukleosoma i funkcionira u zbijanju hromatina u strukture višeg reda. Ovaj gen je bez introna i kodira člana porodice histona H4. Transkripti ovog gena nemaju poliA repove, ali umjesto toga sadrže palindromski terminacijski element. Ovaj gen se nalazi u velikom klasteru histonskih gena na hromosomu 6.[7]
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000278637 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000061482 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics. 40 (2): 314–22. doi:10.1006/geno.1996.4592. PMID 9119399.
- ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
- ^ a b c "Entrez Gene: HIST1H4A histone cluster 1, H4a".
Dopunska literatura
- Pauli U, Chrysogelos S, Stein G, et al. (1987). "Protein-DNA interactions in vivo upstream of a cell cycle-regulated human H4 histone gene". Science. 236 (4806): 1308–11. Bibcode:1987Sci...236.1308P. doi:10.1126/science.3035717. PMID 3035717.
- Albig W, Doenecke D (1998). "The human histone gene cluster at the D6S105 locus". Hum. Genet. 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656. S2CID 38539096.
- El Kharroubi A, Piras G, Zensen R, Martin MA (1998). "Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter". Mol. Cell. Biol. 18 (5): 2535–44. doi:10.1128/mcb.18.5.2535. PMC 110633. PMID 9566873.
- Lorain S, Quivy JP, Monier-Gavelle F, et al. (1998). "Core histones and HIRIP3, a novel histone-binding protein, directly interact with WD repeat protein HIRA". Mol. Cell. Biol. 18 (9): 5546–56. doi:10.1128/MCB.18.9.5546. PMC 109139. PMID 9710638.
- Deng L, de la Fuente C, Fu P, et al. (2001). "Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones". Virology. 277 (2): 278–95. doi:10.1006/viro.2000.0593. PMID 11080476.
- Freire J, Covelo G, Sarandeses C, et al. (2001). "Identification of nuclear-import and cell-cycle regulatory proteins that bind to prothymosin alpha". Biochem. Cell Biol. 79 (2): 123–31. doi:10.1139/bcb-79-2-123. PMID 11310559.
- Deng L, Wang D, de la Fuente C, et al. (2001). "Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA". Virology. 289 (2): 312–26. doi:10.1006/viro.2001.1129. PMID 11689053.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Yoon HG, Chan DW, Huang ZQ, et al. (2003). "Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1". EMBO J. 22 (6): 1336–46. doi:10.1093/emboj/cdg120. PMC 151047. PMID 12628926.
- Lusic M, Marcello A, Cereseto A, Giacca M (2004). "Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter". EMBO J. 22 (24): 6550–61. doi:10.1093/emboj/cdg631. PMC 291826. PMID 14657027.
- Phee H, Abraham RT, Weiss A (2005). "Dynamic recruitment of PAK1 to the immunological synapse is mediated by PIX independently of SLP-76 and Vav1". Nat. Immunol. 6 (6): 608–17. doi:10.1038/ni1199. PMID 15864311. S2CID 23076354.
Vanjski linkovi
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