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INTS11

INTS11
Identifikatori
AliasiINTS11
Vanjski ID-jeviOMIM: 611354 MGI: 1919207 HomoloGene: 9894 GeneCards: INTS11
Lokacija gena (čovjek)
Hromosom 1 (čovjek)
Hrom.Hromosom 1 (čovjek)[1]
Hromosom 1 (čovjek)
Genomska lokacija za INTS11
Genomska lokacija za INTS11
Bend1p36.33Početak1,311,585 bp[1]
Kraj1,324,687 bp[1]
Lokacija gena (miš)
Hromosom 4 (miš)
Hrom.Hromosom 4 (miš)[2]
Hromosom 4 (miš)
Genomska lokacija za INTS11
Genomska lokacija za INTS11
Bend4 E2|4 87.66 cMPočetak155,954,003 bp[2]
Kraj155,973,560 bp[2]
Obrazac RNK ekspresije
Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija hydrolase activity
GO:0001948, GO:0016582 vezivanje za proteine
Ćelijska komponenta blood microparticle
integrator complex
nukleoplazma
citosol
jedro
citoplazma
Biološki proces snRNA processing
snRNA transcription by RNA polymerase II
snRNA 3'-end processing
regulation of RNA splicing
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)
NM_001256456
NM_001256460
NM_001256462
NM_001256463
NM_017871

NM_032179

NM_028020

RefSeq (bjelančevina)

NP_001243385
NP_001243389
NP_001243391
NP_001243392
NP_060341

NP_082296

Lokacija (UCSC)Chr 1: 1.31 – 1.32 MbChr 4: 155.95 – 155.97 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Podjedinica 11 integratorskog kompleksa jest protein koji je kod ljudi kodiran genom CPSF3L sa hromosoma 1.[5][6][7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 600 aminokiselina, a molekulska težina 67.663 Da.[8]

1020304050
MPEIRVTPLGAGQDVGRSCILVSIAGKNVMLDCGMHMGFNDDRRFPDFSY
ITQNGRLTDFLDCVIISHFHLDHCGALPYFSEMVGYDGPIYMTHPTQAIC
PILLEDYRKIAVDKKGEANFFTSQMIKDCMKKVVAVHLHQTVQVDDELEI
KAYYAGHVLGAAMFQIKVGSESVVYTGDYNMTPDRHLGAAWIDKCRPNLL
ITESTYATTIRDSKRCRERDFLKKVHETVERGGKVLIPVFALGRAQELCI
LLETFWERMNLKVPIYFSTGLTEKANHYYKLFIPWTNQKIRKTFVQRNMF
EFKHIKAFDRAFADNPGPMVVFATPGMLHAGQSLQIFRKWAGNEKNMVIM
PGYCVQGTVGHKILSGQRKLEMEGRQVLEVKMQVEYMSFSAHADAKGIMQ
LVGQAEPESVLLVHGEAKKMEFLKQKIEQELRVNCYMPANGETVTLPTSP
SIPVGISLGLLKREMAQGLLPEAKKPRLLHGTLIMKDSNFRLVSSEQALK
ELGLAEHQLRFTCRVHLHDTRKEQETALRVYSHLKSVLKDHCVQHLPDGS
VTVESVLLQAAAPSEDPGTKVLLVSWTYQDEELGSFLTSLLKKGLPQAPS

Reference

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000127054 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029034 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Dominski Z, Yang XC, Purdy M, Wagner EJ, Marzluff WF (Feb 2005). "A CPSF-73 Homologue Is Required for Cell Cycle Progression but Not Cell Growth and Interacts with a Protein Having Features of CPSF-100". Mol Cell Biol. 25 (4): 1489–500. doi:10.1128/MCB.25.4.1489-1500.2005. PMC 548002. PMID 15684398.
  6. ^ Baillat D, Hakimi MA, Naar AM, Shilatifard A, Cooch N, Shiekhattar R (Oct 2005). "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II". Cell. 123 (2): 265–76. doi:10.1016/j.cell.2005.08.019. PMID 16239144. S2CID 18069461.
  7. ^ "Entrez Gene: CPSF3L cleavage and polyadenylation specific factor 3-like".
  8. ^ "UniProt, Q5TA45" (jezik: eng.). Pristupljeno 29. 11. 2021.CS1 održavanje: nepoznati jezik (link)

Dopunska literatura

Vanjski linkovi

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