JPH4
Junktofilin 4 je protein koji je kod ljudi kodiran genom JPH4. [5]
Ovaj gen kodira člana porodice junktofilinskih transmembranskih proteina koji su uključeni u stvaranje kompleksa spojnih membrana između plazmamembrane i endoplazme /
sarkoplazmatskog retikuluma u pobuđenimim ćelijama. Kodirani protein sadrži konzerviranu regiju ponavljanja N-kraja koja se naziva sekvencom zauzimanja i prepoznavanja neksusa membrane koja se nalazi u drugih članova porodice junktofilina. Alternativna prerada rezultira u više varijanti transkripta.
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 628 aminokiselina, a molekulska težina 65.861 Da.[6]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MSPGGKFDFD | DGGCYVGGWE | AGRAHGYGVC | TGPGAQGEYS | GCWAHGFESL | ||||
| GVFTGPGGHS | YQGHWQQGKR | EGLGVERKSR | WTYRGEWLGG | LKGRSGVWES | ||||
| VSGLRYAGLW | KDGFQDGYGT | ETYSDGGTYQ | GQWQAGKRHG | YGVRQSVPYH | ||||
| QAALLRSPRR | TSLDSGHSDP | PTPPPPLPLP | GDEGGSPASG | SRGGFVLAGP | ||||
| GDADGASSRK | RTPAAGGFFR | RSLLLSGLRA | GGRRSSLGSK | RGSLRSEVSS | ||||
| EVGSTGPPGS | EASGPPAAAP | PALIEGSATE | VYAGEWRADR | RSGFGVSQRS | ||||
| NGLRYEGEWL | GNRRHGYGRT | TRPDGSREEG | KYKRNRLVHG | GRVRSLLPLA | ||||
| LRRGKVKEKV | DRAVEGARRA | VSAARQRQEI | AAARAADALL | KAVAASSVAE | ||||
| KAVEAARMAK | LIAQDLQPML | EAPGRRPRQD | SEGSDTEPLD | EDSPGVYENG | ||||
| LTPSEGSPEL | PSSPASSRQP | WRPPACRSPL | PPGGDQGPFS | SPKAWPEEWG | ||||
| GAGAQAEELA | GYEAEDEAGM | QGPGPRDGSP | LLGGCSDSSG | SLREEEGEDE | ||||
| EPLPPLRAPA | GTEPEPIAML | VLRGSSSRGP | DAGCLTEELG | EPAATERPAQ | ||||
| PGAANPLVVG | AVALLDLSLA | FLFSQLLT |
- Simboli
C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000092051 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022208 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Junctophilin 4". Pristupljeno 13. 4. 2013.
- ^ "UniProt, Q96JJ6". Pristupljeno 26. 7. 2021.
Content Disclaimer
Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.
- The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
- There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
- It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
- Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
- Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.
