LCORL
Korepresoliki ligand-ovisni jedarni receptor jest protein koji je kod ljudi kodiran genom LCOR sa hromosoma 4.[5]
Transkripcijski faktori imaju ključnu ulogu u regulaciji razvoja i funkcija nervnog sistema. Transkripcijski faktor Mblk-1 je prethodno prijavljen na ekranu za faktore koji su možda važni za više moždane funkcije pčele. Upregledu iz 2003. ovaj gen posmatran je u vezi sa ekspresijom Mblk-1 koji je identificiran, a zatim daje razmatra i njihove homolog. Proteini porodice Mblk-1 se široko nalaze u životinjama i pokazalo se da utiču na aktivnosti transkripcije. Studije su otkrile da homolozi sisara mogu komunicirati s nekoliko kofaktora i zajedno regulirati transkripciju. Zanimljivo je da je nedavna studija koja je koristila mišje homologe, Mlr1 i Mlr2, pokazala da jedan od njihovih kofaktorskih proteina, NOL4, ima nekoliko varijanti spajanja s različitim efektima na aktivnosti transaktivacije Mlr proteina. Ovi nalazi sugeriraju da postoji dodatni sloj regulacije proteina porodice Mblk-1 varijantama transkripta kofaktora i daju novi uvid u dotadašnje razumijevanje uloga porodice konzerviranih transkripcijskih faktora.[6]
Funkcija
Ovaj gen kodira transkripcijski faktor za koji funkcionira u spermatogenezi. Polimorfizmi u ovom genu su povezani sa mjerama veličine skeletnog okvira i visine odrasle osobe. Alternativna prerada rezultira višestrukim varijantama transkripta.
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000178177 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015882 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Ligand dependent nuclear receptor corepressor like". Pristupljeno 11. 11. 2016.
- ^ Kunieda T, Park JM, Takeuchi H, Kubo T (2003). "Identification and characterization of Mlr1,2: two mouse homologues of Mblk-1, a transcription factor from the honeybee brain(1)". FEBS Lett. 535 (1–3): 61–5. doi:10.1016/s0014-5793(02)03858-9. PMID 12560079. S2CID 83745027.
Dopunska literatura
- Sovio, U; Bennett, AJ; Millwood, IY; Molitor, J; O'Reilly, PF; Timpson, NJ; Kaakinen, M; Laitinen, J; Haukka, J; Pillas, D; Tzoulaki, I; Molitor, J; Hoggart, C; Coin, LJ; Whittaker, J; Pouta, A; Hartikainen, AL; Freimer, NB; Widen, E; Peltonen, L; Elliott, P; McCarthy, MI; Jarvelin, MR (mart 2009). "Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966". PLOS Genetics. 5 (3): e1000409. doi:10.1371/journal.pgen.1000409. PMC 2646138. PMID 19266077.
- Soranzo N, Rivadeneira F, Chinappen-Horsley U, Malkina I, Richards JB, Hammond N, Stolk L, Nica A, Inouye M, Hofman A, Stephens J, Wheeler E, Arp P, Gwilliam R, Jhamai PM, Potter S, Chaney A, Ghori MJ, Ravindrarajah R, Ermakov S, Estrada K, Pols HA, Williams FM, McArdle WL, van Meurs JB, Loos RJ, Dermitzakis ET, Ahmadi KR, Hart DJ, Ouwehand WH, Wareham NJ, Barroso I, Sandhu MS, Strachan DP, Livshits G, Spector TD, Uitterlinden AG, Deloukas P (2009). "Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size". PLOS Genet. 5 (4): e1000445. doi:10.1371/journal.pgen.1000445. PMC 2661236. PMID 19343178.
- Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država, koji je u javnom vlasništvu.
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