LEFTY1
Faktor 1 određenja lijevo-desno jest protein koji je kod ljudi kodiran genom LEFTY1 sa hromosoma 1.[5]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 366 aminokiselina, a molekulska težina Da. 40.880 [6]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MQPLWLCWAL | WVLPLASPGA | ALTGEQLLGS | LLRQLQLKEV | PTLDRADMEE | ||||
| LVIPTHVRAQ | YVALLQRSHG | DRSRGKRFSQ | SFREVAGRFL | ALEASTHLLV | ||||
| FGMEQRLPPN | SELVQAVLRL | FQEPVPKAAL | HRHGRLSPRS | ARARVTVEWL | ||||
| RVRDDGSNRT | SLIDSRLVSV | HESGWKAFDV | TEAVNFWQQL | SRPRQPLLLQ | ||||
| VSVQREHLGP | LASGAHKLVR | FASQGAPAGL | GEPQLELHTL | DLGDYGAQGD | ||||
| CDPEAPMTEG | TRCCRQEMYI | DLQGMKWAEN | WVLEPPGFLA | YECVGTCRQP | ||||
| PEALAFKWPF | LGPRQCIASE | TDSLPMIVSI | KEGGRTRPQV | VSLPNMRVQK | ||||
| CSCASDGALV | PRRLQP |
Funkcija
Ovaj gen kodira člana porodice proteina TGF-beta. Sličan izlučeni protein kod miša ima ulogu u određivanju asimetrije lijevo-desno u sistemima organa tokom razvoja. Alternativna prerada ovog proteina može dati tri različita izoformna proizvoda. Ovaj gen je usko povezan i sa srodnim članom porodice i sa srodnim pseudogenom.
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000243709 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038793 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Left-right determination factor 1". Pristupljeno 3. 8. 2016.
- ^ "UniProt, O75610" (jezik: engleski). Pristupljeno 13. 12. 2021.
Dopunska literatura
- Besser D (2004). "Expression of nodal, lefty-a, and lefty-B in undifferentiated human embryonic stem cells requires activation of Smad2/3". J. Biol. Chem. 279 (43): 45076–84. doi:10.1074/jbc.M404979200. PMID 15308665.
Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država, koji je u javnom vlasništvu.
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