LILRB2
Receptor iz porodice imunoglobulinu sličnih receptora leukocita, podgrupa B, član 2, je protein koji je kod ljudi kodiran genom LILRB2.[1][2][3]
Ovaj gen je član porodice receptora sličnih imunoglobulinima leukocita (LIR), koja se nalazi u genskom klasteru na hromosomskoj regiji 19q13.4. Kodirani protein pripada klasi receptora podgrupe B iz LIR porodice, koji sadrže dva ili četiri vanćelijska imunoglobulinska domena, transmembranski domen i dva do četiri citoplazmatska inhibitorna motiva bazirana na tirozinima imunoreceptora (ITIM). Receptor se izražava na imunim ćelijama, gdje se veže za MHC molekule klase I na ćelijama koje prezentuju antigene i prenosi negativni signal koji inhibira stimulaciju imunskog odgovora. Smatra se da kontroliše upalne odgovore i citotoksičnost kako bi usmjerio imuni odgovor i ograničio autoreaktivnost. Za ovaj gen je pronađeno više transkriptnih varijanti koje kodiraju različite izoforme proteina.[3]
LILRB2 ima ključnu ulogu u inhibiciji regeneracije aksona i funkcionalnog oporavka nakon povrede mozga. Međutim, nedavne studije pokazuju da je LILRB2 receptor za β-amiloid i da može doprinijeti gubitku sinapsi i kognitivnim oštećenjima kod Alzheimerove bolesti.[4]
Interakcije
Pokazano je da LILRB2 stupa u interakciju s proteinom PTPN6.[5][6]
Vidi također
Reference
- ^ Cella, Marina; Döhring, Christian; Samaridis, Jacqueline; Dessing, Mark; Brockhaus, Manfred; Lanzavecchia, Antonio; Colonna, Marco (19. 5. 1997). "A Novel Inhibitory Receptor (ILT3) Expressed on Monocytes, Macrophages, and Dendritic Cells Involved in Antigen Processing". The Journal of Experimental Medicine (jezik: engleski). 185 (10): 1743–1751. doi:10.1084/jem.185.10.1743. ISSN 0022-1007. PMC 2196312.
- ^ Samaridis, Jacqueline; Colonna, Marco (1997). "Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: Structural evidence for new stimulatory and inhibitory pathways". European Journal of Immunology (jezik: engleski). 27 (3): 660–665. doi:10.1002/eji.1830270313. ISSN 0014-2980.
- ^ a b "LILRB2 leukocyte immunoglobulin like receptor B2 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Pristupljeno 29. 7. 2025.
- ^ Kim, Taeho; Vidal, George S.; Djurisic, Maja; William, Christopher M.; Birnbaum, Michael E.; Garcia, K. Christopher; Hyman, Bradley T.; Shatz, Carla J. (20. 9. 2013). "Human LilrB2 Is a β-Amyloid Receptor and Its Murine Homolog PirB Regulates Synaptic Plasticity in an Alzheimer's Model". Science (jezik: engleski). 341 (6152): 1399–1404. doi:10.1126/science.1242077. ISSN 0036-8075. PMC 3853120.
- ^ Fanger, Neil A.; Cosman, David; Peterson, Lori; Braddy, Steven C.; Maliszewski, Charles R.; Borges, Luis (1998). "The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes". European Journal of Immunology (jezik: engleski). 28 (11): 3423–3434. doi:10.1002/(SICI)1521-4141(199811)28:11<3423::AID-IMMU3423>3.0.CO;2-2. ISSN 0014-2980.
- ^ Colonna, M.; Samaridis, J.; Cella, M.; Angman, L.; Allen, R. L.; O'Callaghan, C. A.; Dunbar, R.; Ogg, G. S.; Cerundolo, V. (1. 4. 1998). "Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules". Journal of Immunology (Baltimore, Md.: 1950). 160 (7): 3096–3100. ISSN 0022-1767. PMID 9531263.
Content Disclaimer
Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.
- The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
- There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
- It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
- Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
- Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.
