LIMD1
Protein 1 sa LIM domenom jest protein koji je kod ljudi kodiran genom LIMD1 sa hromosoma 3.[5][6]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 676 aminokiselina, а molekulska težina 72.190 Da.[7]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MDKYDDLGLE | ASKFIEDLNM | YEASKDGLFR | VDKGAGNNPE | FEETRRVFAT | ||||
| KMAKIHLQQQ | QQQLLQEETL | PRGSRGPVNG | GGRLGPQARW | EVVGSKLTVD | ||||
| GAAKPPLAAS | TGAPGAVTTL | AAGQPPYPPQ | EQRSRPYLHG | TRHGSQDCGS | ||||
| RESLATSEMS | AFHQPGPCED | PSCLTHGDYY | DNLSLASPKW | GDKPGVSPSI | ||||
| GLSVGSGWPS | SPGSDPPLPK | PCGDHPLNHR | QLSLSSSRSS | EGSLGGQNSG | ||||
| IGGRSSEKPT | GLWSTASSQR | VSPGLPSPNL | ENGAPAVGPV | QPRTPSVSAP | ||||
| LALSCPRQGG | LPRSNSGLGG | EVSGVMSKPN | VDPQPWFQDG | PKSYLSSSAP | ||||
| SSSPAGLDGS | QQGAVPGLGP | KPGCTDLGTG | PKLSPTSLVH | PVMSTLPELS | ||||
| CKEGPLGWSS | DGSLGSVLLD | SPSSPRVRLP | CQPLVPGPEL | RPSAAELKLE | ||||
| ALTQRLEREM | DAHPKADYFG | ACVKCSKGVF | GAGQACQAMG | NLYHDTCFTC | ||||
| AACSRKLRGK | AFYFVNGKVF | CEEDFLYSGF | QQSADRCFLC | GHLIMDMILQ | ||||
| ALGKSYHPGC | FRCVICNECL | DGVPFTVDSE | NKIYCVRDYH | KVLAPKCAAC | ||||
| GLPILPPEGS | DETIRVVSMD | RDYHVECYHC | EDCGLELNDE | DGHRCYPLED | ||||
| HLFCHSCHVK | RLEKRPSSTA | LHQHHF |
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000144791 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025239 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Kiss H, Kedra D, Yang Y, Kost-Alimova M, Kiss C, O'Brien KP, Fransson I, Klein G, Imreh S, Dumanski JP (Feb 2000). "A novel gene containing LIM domains (LIMD1) is located within the common eliminated region 1 (C3CER1) in 3p21.3". Hum Genet. 105 (6): 552–9. doi:10.1007/s004390051144. PMID 10647888.
- ^ "Entrez Gene: LIMD1 LIM domains containing 1".
- ^ "UniProt, Q9UGP4" (jezik: аeng.). Pristupljeno 4. 11. 2021.CS1 održavanje: nepoznati jezik (link)
Dopunska literatura
- Jiang T, Altman S (2001). "Protein-protein interactions with subunits of human nuclear RNase P." Proc. Natl. Acad. Sci. U.S.A. 98 (3): 920–5. doi:10.1073/pnas.021561498. PMC 14685. PMID 11158571.
- Kiss H, Kedra D, Kiss C, et al. (2001). "The LZTFL1 gene is a part of a transcriptional map covering 250 kb within the common eliminated region 1 (C3CER1) in 3p21.3". Genomics. 73 (1): 10–9. doi:10.1006/geno.2000.6498. PMID 11352561.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
- Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Sharp TV, Munoz F, Bourboulia D, et al. (2004). "LIM domains-containing protein 1 (LIMD1), a tumor suppressor encoded at chromosome 3p21.3, binds pRB and represses E2F-driven transcription". Proc. Natl. Acad. Sci. U.S.A. 101 (47): 16531–6. doi:10.1073/pnas.0407123101. PMC 534532. PMID 15542589.
- Feng Y, Longmore GD (2005). "The LIM protein Ajuba influences interleukin-1-induced NF-kappaB activation by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling complex". Mol. Cell. Biol. 25 (10): 4010–22. doi:10.1128/MCB.25.10.4010-4022.2005. PMC 1087715. PMID 15870274.
- Huggins CJ, Gill M, Andrulis IL (2007). "Identification of rare variants in the hLIMD1 gene in breast cancer". Cancer Genet. Cytogenet. 178 (1): 36–41. doi:10.1016/j.cancergencyto.2007.06.007. PMID 17889706.
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