Dugolančane nekodirajuće RNK (lncRNA) funkcioniraju u razvoju i napredovanju raka, ali je do danas okarakterisan samo mali dio lncRNA. Novi transkript lncRNA, dužine 2,53 kb, identifikovan je analizom sekvencioniranja transkriptoma i nazvan je p53-inducibilnim RNKtranskriptom 1 (PICART1). Utvrđeno je da je PICART1 pojačano reguliran p53 preko p53-vezujućeg mjesta na -1808 do -1783 bp. U ćelijama i tkivima raka dojke i kolorektumskog karcinoma otkriveno je da je ekspresija PICART1 smanjena. Ektopijska ekspresija PICART1 potisnula je rast, proliferaciju, [[ćelijska migracija|migracijugg i invaziju ćelija MCF7, MDA-MB-231 i HCT116, dok je utišavanje PICART1 stimulisalo rast i migraciju ćelija. U ovim ćelijama ekspresija PICART1 je potisnula nivoe p-AKT (Thr308 i Ser473) i p-GSK3β (Ser9), te je shodno tome smanjena ekspresija β-katenina, ciklina D1 i c-Myc, dok je ekspresija p21Waf/cip1 bila manje povećana. Zajedno, ovi podaci sugeriraju da je PICART1 nova p53-inducibilna tumor-supresorska lncRNK, koja funkcionira kroz AKT/GSK3β/β-katenin signalnu kaskadu.[3]
Reference
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Yu Cao, Minglin Lin , Yiwen Bu, Hongyan Ling, Yingchun He, Chenfei Huang, Yi Shen , Bob Song, Deliang Cao (2017): p53-inducible long non-coding RNA PICART1 mediates cancer cell proliferation and migration. Int J Oncol, 50(5):1671-1682; pmid: 28339031; doi: 10.3892/ijo.2017.3918
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