MAB21L2
| MAB21L2 | |||||||||||||||||||||||||
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| Identifikatori | |||||||||||||||||||||||||
| Aliasi | MAB21L2 | ||||||||||||||||||||||||
| Vanjski ID-jevi | OMIM: 604357 MGI: 1346022 HomoloGene: 7824 GeneCards: MAB21L2 | ||||||||||||||||||||||||
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| Ortolozi | |||||||||||||||||||||||||
| Vrste | Čovjek | Miš | |||||||||||||||||||||||
| Entrez | |||||||||||||||||||||||||
| Ensembl | |||||||||||||||||||||||||
| UniProt | |||||||||||||||||||||||||
| RefSeq (mRNK) | |||||||||||||||||||||||||
| RefSeq (bjelančevina) | |||||||||||||||||||||||||
| Lokacija (UCSC) | Chr 4: 150.58 – 150.58 Mb | Chr 3: 86.45 – 86.46 Mb | |||||||||||||||||||||||
| PubMed pretraga | [3] | [4] | |||||||||||||||||||||||
| Wikipodaci | |||||||||||||||||||||||||
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Mab-21-liki protein 2 (C. elegans) je protein koji je kod ljudi kodiran genom MAB21L2 sa hromosoma 4.[5]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 359 aminokiselina, a molekulska težina 40.923 Da.[6]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MIAAQAKLVY | QLNKYYTERC | QARKAAIAKT | IREVCKVVSD | VLKEVEVQEP | ||||
| RFISSLSEID | ARYEGLEVIS | PTEFEVVLYL | NQMGVFNFVD | DGSLPGCAVL | ||||
| KLSDGRKRSM | SLWVEFITAS | GYLSARKIRS | RFQTLVAQAV | DKCSYRDVVK | ||||
| MIADTSEVKL | RIRERYVVQI | TPAFKCTGIW | PRSAAQWPMP | HIPWPGPNRV | ||||
| AEVKAEGFNL | LSKECYSLTG | KQSSAESDAW | VLQFGEAENR | LLMGGCRNKC | ||||
| LSVLKTLRDR | HLELPGQPLN | NYHMKTLLLY | ECEKHPRETD | WDESCLGDRL | ||||
| NGILLQLISC | LQCRRCPHYF | LPNLDLFQGK | PHSALESAAK | QTWRLAREIL | ||||
| TNPKSLDKL |
Funkcija
Ovaj gen, sličan MAB-21 C. elegans jest ćelijski gen koji određuje sudbinu, nizvodni cilj signalizacije transformirajućeg faktora rasta-beta. Smatra se da može biti uključen u razvoj nervnog sistema. Protein kodiran ovim genom je prvenstveno jedarni, iako je uočena određena citoplazmatska lokalizacija (prema RefSeq, juli 2008.).
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000181541 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000057777 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Mab-21-like 2 (C. elegans)".
- ^ "UniProt, Q9Y586" (jezik: engleski). Pristupljeno 29. 10. 2021.
Dopunska literatura
- Mariani M, Baldessari D, Francisconi S, Viggiano L, Rocchi M, Zappavigna V, Malgaretti N, Consalez GG (decembar 1999). "Two murine and human homologs of mab-21, a cell fate determination gene involved in Caenorhabditis elegans neural development". Human Molecular Genetics. 8 (13): 2397–406. doi:10.1093/hmg/8.13.2397. PMID 10556287.
Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država, koji je u javnom vlasništvu.
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