MAN1A2
Mannozil-oligosaharidna 1,2-alfa-manozidaza IB jest enzim koji je kod ljudi kodiran genom MAN1A2 sa hromosoma 1.[5][6]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 641 aminokiselina, a molekulska težina 73.004 Da. [7]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MTTPALLPLS | GRRIPPLNLG | PPSFPHHRAT | LRLSEKFILL | LILSAFITLC | ||||
| FGAFFFLPDS | SKHKRFDLGL | EDVLIPHVDA | GKGAKNPGVF | LIHGPDEHRH | ||||
| REEEERLRNK | IRADHEKALE | EAKEKLRKSR | EEIRAEIQTE | KNKVVQEMKI | ||||
| KENKPLPPVP | IPNLVGIRGG | DPEDNDIREK | REKIKEMMKH | AWDNYRTYGW | ||||
| GHNELRPIAR | KGHSPNIFGS | SQMGATIVDA | LDTLYIMGLH | DEFLDGQRWI | ||||
| EDNLDFSVNS | EVSVFEVNIR | FIGGLLAAYY | LSGEEIFKIK | AVQLAEKLLP | ||||
| AFNTPTGIPW | AMVNLKSGVG | RNWGWASAGS | SILAEFGTLH | MEFIHLSYLT | ||||
| GDLTYYKKVM | HIRKLLQKMD | RPNGLYPNYL | NPRTGRWGQY | HTSVGGLGDS | ||||
| FYEYLLKAWL | MSDKTDHEAR | KMYDDAIEAI | EKHLIKKSRG | GLTFIGEWKN | ||||
| GHLEKKMGHL | ACFAGGMFAL | GADGSRADKA | GHYLELGAEI | ARTCHESYDR | ||||
| TALKLGPESF | KFDGAVEAVA | VRQAEKYYIL | RPEVIETYWY | LWRFTHDPRY | ||||
| RQWGWEAALA | IEKYCRVNGG | FSGVKDVYSS | TPTHDDVQQS | FFLAETLKYL | ||||
| YLLFSGDDLL | PLDHWVFNTE | AHPLPVLHLA | NTTLSGNPAV | R |
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000198162 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000008763 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Tremblay LO, Campbell Dyke N, Herscovics A (Jul 1998). "Molecular cloning, chromosomal mapping and tissue-specific expression of a novel human alpha1,2-mannosidase gene involved in N-glycan maturation". Glycobiology. 8 (6): 585–595. doi:10.1093/glycob/8.6.585. PMID 9592125.
- ^ "Entrez Gene: MAN1A2 mannosidase, alpha, class 1A, member 2".
- ^ "UniProt, O60476" (jezik: eng.). Pristupljeno 30. 11. 2021.CS1 održavanje: nepoznati jezik (link)
Dopunska literatura
- Land A, Braakman I (2001). "Folding of the human immunodeficiency virus type 1 envelope glycoprotein in the endoplasmic reticulum". Biochimie. 83 (8): 783–790. doi:10.1016/S0300-9084(01)01314-1. hdl:1874/5091. PMID 11530211.
- Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–321. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–1332. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
- Hart ML, Saifuddin M, Spear GT (2003). "Glycosylation inhibitors and neuraminidase enhance human immunodeficiency virus type 1 binding and neutralization by mannose-binding lectin". J. Gen. Virol. 84 (Pt 2): 353–360. doi:10.1099/vir.0.18734-0. PMID 12560567.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Papandreou MJ, Fenouillet E (1997). "Effect of various glycosidase treatments on the resistance of the HIV-1 envelope to degradation". FEBS Lett. 406 (1–2): 191–195. doi:10.1016/S0014-5793(97)00273-1. PMID 9109416. S2CID 17660.
- Hu H, Shioda T, Moriya C, et al. (1996). "Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface". J. Virol. 70 (11): 7462–7470. doi:10.1128/jvi.70.11.7462-7470.1996. PMC 190813. PMID 8892864.
- Bolmstedt A, Sjölander S, Hansen JE, et al. (1996). "Influence of N-linked glycans in V4-V5 region of human immunodeficiency virus type 1 glycoprotein gp160 on induction of a virus-neutralizing humoral response". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 12 (3): 213–220. doi:10.1097/00042560-199607000-00001. PMID 8673525.
- Yeh JC, Seals JR, Murphy CI, et al. (1993). "Site-specific N-glycosylation and oligosaccharide structures of recombinant HIV-1 gp120 derived from a baculovirus expression system". Biochemistry. 32 (41): 11087–11099. doi:10.1021/bi00092a019. PMID 8218172.
- Fenouillet E, Jones I, Powell B, et al. (1993). "Functional role of the glycan cluster of the human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain". J. Virol. 67 (1): 150–160. doi:10.1128/jvi.67.1.150-160.1993. PMC 237347. PMID 8093218.
- Montefiori DC, Robinson WE, Mitchell WM (1988). "Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1". Proc. Natl. Acad. Sci. U.S.A. 85 (23): 9248–9252. Bibcode:1988PNAS...85.9248M. doi:10.1073/pnas.85.23.9248. PMC 282716. PMID 3264072.
- Blough HA, Pauwels R, De Clercq E, et al. (1987). "Glycosylation inhibitors block the expression of LAV/HTLV-III (HIV) glycoproteins". Biochem. Biophys. Res. Commun. 141 (1): 33–38. doi:10.1016/S0006-291X(86)80330-8. PMID 3099781.
- Robinson WE, Montefiori DC, Mitchell WM (1988). "Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis". AIDS Res. Hum. Retroviruses. 3 (3): 265–282. doi:10.1089/aid.1987.3.265. PMID 2829950.
- Kozarsky K, Penman M, Basiripour L, et al. (1989). "Glycosylation and processing of the human immunodeficiency virus type 1 envelope protein". J. Acquir. Immune Defic. Syndr. 2 (2): 163–169. PMID 2649653.
- Dewar RL, Vasudevachari MB, Natarajan V, Salzman NP (1989). "Biosynthesis and processing of human immunodeficiency virus type 1 envelope glycoproteins: effects of monensin on glycosylation and transport". J. Virol. 63 (6): 2452–2456. doi:10.1128/jvi.63.6.2452-2456.1989. PMC 250699. PMID 2542563.
Vanjski linkovi
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