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MIR146A

MIR146A

Identifikatori

Vanjski ID-jevi

OMIM: 610566 GeneCards: MIR146A

Lokacija gena (čovjek)

Hrom.	Hromosom 5 (čovjek)^[1]

Bend	5q33.3	Početak	160,485,352 bp^[1]
Bend	5q33.3	Kraj	160,485,450 bp^[1]

Vrste

Čovjek

Miš


406938


n/a


ENSG00000283733


n/a


n a


n/a

RefSeq (mRNK)


n/a


n/a

RefSeq (bjelančevina)


n/a


n/a

Lokacija (UCSC)

Chr 5: 160.49 – 160.49 Mb

n/a

PubMed pretraga

^[2]

n/a

Pogledaj/uredi – čovjek

MikroRNK 146a jest mala nekodirajuća RNK koja je kod ljudi kodirana genom MIR146A sa hromosoma 5.^[3]

mikroRNK (miRNK) su kratke (20-24 nt) nekodirajuće RNK koje su uključene u posttranskripcijsku regulaciju ekspresije gena u višećelijskim organizmima, utičući i na stabilnost i na translaciju iRNK. miRNK se transkribira RNK-polimerazom II, kao dio kapiranih i poliadeniliranih primarnih transkripata (pri-miRNK), koji mogu biti protein-kodirajući ili nekodirajući. Primarni transkript se cijepa enzimom Drosha (ribonukleaza III), kako bi se proizvela približno 70-nt prekursorska miRNK iz matične petlje (pre-miRNK), koja se dalje cijepa citoplazmatskom Dicer ribonukleazom, kako bi nastali proizvodi: zrela miRNK i antisens miRNK sa zjezdomvi (miRNK*). Zrela miRNK ugrađena je u kompleks za utišavanje induciran RNK (RISC), koji prepoznaje ciljane mRNK, preko nesavršenog uparivanja baze s miRNK i najčešće rezultira translacijskom inhibicijom ili destabilizacijom ciljane iRNK. RefSeq predstavlja predviđenu matičnu petlju mikroRNK.^[3]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000283733 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: MicroRNA 146a". Pristupljeno 27. 1. 2012.

Dopunska literatura

Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T (april 2002). "Identification of tissue-specific microRNAs from mouse". Current Biology. 12 (9): 735–9. doi:10.1016/S0960-9822(02)00809-6. PMID 12007417.
Cai X, Lu S, Zhang Z, Gonzalez CM, Damania B, Cullen BR (april 2005). "Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells". Proceedings of the National Academy of Sciences of the United States of America. 102 (15): 5570–5. Bibcode:2005PNAS..102.5570C. doi:10.1073/pnas.0408192102. PMC 556237. PMID 15800047.
He H, Jazdzewski K, Li W, Liyanarachchi S, Nagy R, Volinia S, Calin GA, Liu CG, Franssila K, Suster S, Kloos RT, Croce CM, de la Chapelle A (decembar 2005). "The role of microRNA genes in papillary thyroid carcinoma". Proceedings of the National Academy of Sciences of the United States of America. 102 (52): 19075–80. Bibcode:2005PNAS..10219075H. doi:10.1073/pnas.0509603102. PMC 1323209. PMID 16365291.
Taganov KD, Boldin MP, Chang KJ, Baltimore D (august 2006). "NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses". Proceedings of the National Academy of Sciences of the United States of America. 103 (33): 12481–6. Bibcode:2006PNAS..10312481T. doi:10.1073/pnas.0605298103. PMC 1567904. PMID 16885212.
Sonkoly E, Wei T, Janson PC, Sääf A, Lundeberg L, Tengvall-Linder M, Norstedt G, Alenius H, Homey B, Scheynius A, Ståhle M, Pivarcsi A (juli 2007). Zimmer J (ured.). "MicroRNAs: novel regulators involved in the pathogenesis of psoriasis?". PLOS ONE. 2 (7): e610. Bibcode:2007PLoSO...2..610S. doi:10.1371/journal.pone.0000610. PMC 1905940. PMID 17622355.
Cameron JE, Yin Q, Fewell C, Lacey M, McBride J, Wang X, Lin Z, Schaefer BC, Flemington EK (februar 2008). "Epstein-Barr virus latent membrane protein 1 induces cellular MicroRNA miR-146a, a modulator of lymphocyte signaling pathways". Journal of Virology. 82 (4): 1946–58. doi:10.1128/JVI.02136-07. PMC 2258704. PMID 18057241.
Stanczyk J, Pedrioli DM, Brentano F, Sanchez-Pernaute O, Kolling C, Gay RE, Detmar M, Gay S, Kyburz D (april 2008). "Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis". Arthritis and Rheumatism. 58 (4): 1001–9. doi:10.1002/art.23386. PMID 18383392.
Perry MM, Moschos SA, Williams AE, Shepherd NJ, Larner-Svensson HM, Lindsay MA (april 2008). "Rapid changes in microRNA-146a expression negatively regulate the IL-1beta-induced inflammatory response in human lung alveolar epithelial cells". Journal of Immunology. 180 (8): 5689–98. doi:10.4049/jimmunol.180.8.5689. PMC 2639646. PMID 18390754.
Jazdzewski K, Murray EL, Franssila K, Jarzab B, Schoenberg DR, de la Chapelle A (maj 2008). "Common SNP in pre-miR-146a decreases mature miR expression and predisposes to papillary thyroid carcinoma". Proceedings of the National Academy of Sciences of the United States of America. 105 (20): 7269–74. Bibcode:2008PNAS..105.7269J. doi:10.1073/pnas.0802682105. PMC 2438239. PMID 18474871.
Labbaye C, Spinello I, Quaranta MT, Pelosi E, Pasquini L, Petrucci E, Biffoni M, Nuzzolo ER, Billi M, Foà R, Brunetti E, Grignani F, Testa U, Peschle C (juli 2008). "A three-step pathway comprising PLZF/miR-146a/CXCR4 controls megakaryopoiesis". Nature Cell Biology. 10 (7): 788–801. doi:10.1038/ncb1741. PMID 18568019. S2CID 30191805.

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