MOGAT2
2-Acilglicerol O-aciltransferaza 2, znana i kao acil-CoA:monoacilglicerol-aciltransferaza 2 (MGAT2) ili diacilglicerol O-aciltransferazni kandidat 5 (DC5) je enzimkoji je kod ljudi kodiran genom MOGAT2.
MOGAT2 i srodni MOGAT3 geni su članovi porodice acilglicerol o-aciltransferaza (DGAT2/MOGAT) i uključeni su u sintezu diacilglicerola (DAG) i triacilglicerola (TAG) iz monoacilglicerola (MAG).
MOGAT2 i MOGAT3 su geni sa jednom kopijom kod gotovo svih sisara. Međutim, kod preživara oba gena su prošla tandemsku ekspanziju gena), što ukazuje na razvoj funkcionalnosti. MOGAT2 ima više od pet tandemski dupliciranih kopija kod ovaca, pri čemu je prva kopija izražena u duodenumu, a posljednja eksprimirana je u koži, bez ikakvog izraza kopije otkrivene u jetri.[5][6][7]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 334 aminokiseline, a molekulska težina 38.196 Da.[8]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MVEFAPLFMP | WERRLQTLAV | LQFVFSFLAL | AEICTVGFIA | LLFTRFWLLT | ||||
| VLYAAWWYLD | RDKPRQGGRH | IQAIRCWTIW | KYMKDYFPIS | LVKTAELDPS | ||||
| RNYIAGFHPH | GVLAVGAFAN | LCTESTGFSS | IFPGIRPHLM | MLTLWFRAPF | ||||
| FRDYIMSAGL | VTSEKESAAH | ILNRKGGGNL | LGIIVGGAQE | ALDARPGSFT | ||||
| LLLRNRKGFV | RLALTHGAPL | VPIFSFGEND | LFDQIPNSSG | SWLRYIQNRL | ||||
| QKIMGISLPL | FHGRGVFQYS | FGLIPYRRPI | TTVVGKPIEV | QKTLHPSEEE | ||||
| VNQLHQRYIK | ELCNLFEAHK | LKFNIPADQH | LEFC |
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000166391 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052396 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Winter A, van Eckeveld M, Bininda-Emonds OR, Habermann FA, Fries R (Feb 2004). "Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos taurus) and other mammals". Cytogenetic and Genome Research. 102 (1–4): 42–7. doi:10.1159/000075723. PMID 14970677. S2CID 25524277.
- ^ "Entrez Gene: MOGAT2 monoacylglycerol O-acyltransferase 2".
- ^ Jiang Y, Xie M, Chen W, Talbot R, Maddox JF, Faraut T, Wu C, Muzny DM, Li Y, Zhang W, Stanton JA, Brauning R, Barris WC, Hourlier T, Aken BL, Searle SM, Adelson DL, Bian C, Cam GR, Chen Y, Cheng S, DeSilva U, Dixen K, Dong Y, Fan G, Franklin IR, Fu S, Fuentes-Utrilla P, Guan R, Highland MA, Holder ME, Huang G, Ingham AB, Jhangiani SN, Kalra D, Kovar CL, Lee SL, Liu W, Liu X, Lu C, Lv T, Mathew T, McWilliam S, Menzies M, Pan S, Robelin D, Servin B, Townley D, Wang W, Wei B, White SN, Yang X, Ye C, Yue Y, Zeng P, Zhou Q, Hansen JB, Kristiansen K, Gibbs RA, Flicek P, Warkup CC, Jones HE, Oddy VH, Nicholas FW, McEwan JC, Kijas JW, Wang J, Worley KC, Archibald AL, Cockett N, Xu X, Wang W, Dalrymple BP (Jun 2014). "The sheep genome illuminates biology of the rumen and lipid metabolism". Science. 344 (6188): 1168–73. doi:10.1126/science.1252806. PMC 4157056. PMID 24904168.
- ^ "UniProt, Q3SYC2". Pristupljeno 24. 8. 2021.
Dopunska literatura
- Cao J, Hawkins E, Brozinick J, Liu X, Zhang H, Burn P, Shi Y (Apr 2004). "A predominant role of acyl-CoA:monoacylglycerol acyltransferase-2 in dietary fat absorption implicated by tissue distribution, subcellular localization, and up-regulation by high fat diet". The Journal of Biological Chemistry. 279 (18): 18878–86. doi:10.1074/jbc.M313272200. PMID 14966132.
- Lockwood JF, Cao J, Burn P, Shi Y (Nov 2003). "Human intestinal monoacylglycerol acyltransferase: differential features in tissue expression and activity". American Journal of Physiology. Endocrinology and Metabolism. 285 (5): E927–37. doi:10.1152/ajpendo.00179.2003. PMID 12824082.
- Yen CL, Farese RV (maj 2003). "MGAT2, a monoacylglycerol acyltransferase expressed in the small intestine". The Journal of Biological Chemistry. 278 (20): 18532–7. doi:10.1074/jbc.M301633200. PMID 12621063.
- Cao J, Lockwood J, Burn P, Shi Y (Apr 2003). "Cloning and functional characterization of a mouse intestinal acyl-CoA:monoacylglycerol acyltransferase, MGAT2". The Journal of Biological Chemistry. 278 (16): 13860–6. doi:10.1074/jbc.M300139200. PMID 12576479.
Vanjski linkovi
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