MTIF2
Mitohondrijski faktor translacijske inicijacije IF-2 jest protein koji je kod ljudi kodiran genom MTIF2 sa hromosoma 2.[5][6][7]
Amiokiselininska sekvenca
Dužina polipeptidnog lanca je 727 aminokiselina, a molkekulska iežina 81.317 Da.[8]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MNQKLLKLEN | LLRFHTIYRQ | LHSLCQRRAL | RQWRHGFSSA | YPVWTAQLCA | ||||
| WPWPTDVLTG | AALSQYRLLV | TKKEEGPWKS | QLSSTKSKKV | VEVWIGMTIE | ||||
| ELARAMEKNT | DYVYEALLNT | DIDIDSLEAD | SHLDEVWIKE | VITKAGMKLK | ||||
| WSKLKQDKVR | KNKDAVRRPQ | ADPALLTPRS | PVVTIMGHVD | HGKTTLLDKF | ||||
| RKTQVAAVET | GGITQHIGAF | LVSLPSGEKI | TFLDTPGHAA | FSAMRARGAQ | ||||
| VTDIVVLVVA | ADDGVMKQTV | ESIQHAKDAQ | VPIILAVNKC | DKAEADPEKV | ||||
| KKELLAYDVV | CEDYGGDVQA | VPVSALTGDN | LMALAEATVA | LAEMLELKAD | ||||
| PNGPVEGTVI | ESFTDKGRGL | VTTAIIQRGT | LRKGSVLVAG | KCWAKVRLMF | ||||
| DENGKTIDEA | YPSMPVGITG | WRDLPSAGEE | ILEVESEPRA | REVVDWRKYE | ||||
| QEQEKGQEDL | KIIEEKRKEH | KEAHQKAREK | YGHLLWKKRS | ILRFLERKEQ | ||||
| IPLKPKEKRE | RDSNVLSVII | KGDVDGSVEA | ILNIIDTYDA | SHECELELVH | ||||
| FGVGDVSAND | VNLAETFDGV | IYGFNVNAGN | VIQQSAAKKG | VKIKLHKIIY | ||||
| RLVEDLQEEL | SSRLPCAVEE | HPVGEASILA | TFSVTEGKKK | VPVAGCRVQK | ||||
| GQLEKQKKFK | LTRNGHVIWK | GSLTSLKHHK | DDISIVKTGM | DCGLSLDEDN | ||||
| MEFQVGDRIV | CYEEKQIQAK | TSWDPGF |
Funkcija
Tokom inicijacije biosinteze proteina, inicijacijski faktor-2 (IF-2) promovira vezivanje inicijatorske tRNK za malu podjedinicu ribosoma na način ovisan o GTP. Prokariotski IF-2 je jedan polipeptid, dok je eukariotski citoplazmatski IF-2 (eIF-2) trimerni protein. Mitohondrije goveđe jetre sadrže IF-2(mt), monomerni protein od 85 kD koji je ekvivalentan prokariotskom IF-2. Predviđeni ljudski protein od 727 aminokiselina sadrži sekvencu od 29 aminokiselina. Ljudski IF-2(mt) dijeli 32 do 38% identičnosti aminokiselinske sekvence sa IF-2(mt) kvasca i nekoliko prokariotskih IF-2, sa najvećim stepenom konzerviranosti u G-domenima proteina. Za ovaj gen su pronađene dvije varijante transkripta koje kodiraju isti protein.[7]
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000085760 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020459 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Bonner DS, Wiley JE, Farwell MA (Mar 1999). "Assignment1 of the mitochondrial translational initiation factor 2 gene (MTIF2) to human chromosome 2 bands p16→p14 by in situ hybridization and with somatic cell hybrids". Cytogenet Cell Genet. 83 (1–2): 80–1. doi:10.1159/000015133. PMID 9925935. S2CID 23290955.
- ^ Ma L, Spremulli LL (Feb 1995). "Cloning and sequence analysis of the human mitochondrial translational initiation factor 2 cDNA". J Biol Chem. 270 (4): 1859–65. doi:10.1074/jbc.270.4.1859. PMID 7829522.
- ^ a b "Entrez Gene: MTIF2 mitochondrial translational initiation factor 2".
- ^ "UniProt, P46199" (jezik: engleski). Pristupljeno 13. 11. 2021.
Dopunska literatura
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Overman RG, Enderle PJ, Farrow JM, et al. (2003). "The human mitochondrial translation initiation factor 2 gene (MTIF2): transcriptional analysis and identification of a pseudogene". Biochim. Biophys. Acta. 1628 (3): 195–205. doi:10.1016/s0167-4781(03)00144-1. PMID 12932832.
- Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
- Miura E, Kato Y, Matsushima R, et al. (2007). "The Balance between Protein Synthesis and Degradation in Chloroplasts Determines Leaf Variegation in Arabidopsis yellow variegated Mutants". Plant Cell. 19 (4): 1313–28. doi:10.1105/tpc.106.049270. PMC 1913758. PMID 17416734.
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