NPDPA
| N-(propan-2-il)-1,2-difeniletilamin | |
|---|---|
 | |
| Općenito | |
| Hemijski spoj | N-(propan-2-il)-1,2-difeniletilamin |
| Druga imena | PSA, NPDPA |
| Molekularna formula | C17H21N |
| CAS registarski broj | [http://www.nlm.nih.gov/cgi/mesh/2006/MB_cgi?term=774118-46-6
PubChem: 110817] |
| SMILES | c1ccccc1CC(NC(C)C)c2ccccc2 |
| Osobine1 | |
| 1 Gdje god je moguće korištene su SI jedinice. Ako nije drugačije naznačeno, dati podaci vrijede pri standardnim uslovima. | |
NPDPA, poznat i kao izopropilfenidin ili izofenidin, je disociativni anestetik koji se prodaje na mreži kao dizajnerski lijek i halucinogen.[1][2][3][4] Prvi put je identificiran u Njemačkoj 2008., i premda se nikada nije toliko prodavao kao srodni spojevi kao što su difenidin i efenidin, nastavio se povremeno pojavljivati u zaplijenjenim uzorcima droga[5] a u Švedskoj zabranjen je 2015.
Metabolizam
Metabolički put izopropilfenidina sastoji se od N-oksidacije, N-dealkilacije, mono- i bis-hidroksilacije benzenskog prstena i hidroksilacije fenilnog prstena, tek nakon N-dealkilacije. Dihidroksi metaboliti konjugirani su metilacijom jedne hidroksi grupe, a hidroksi metaboliti glukuronidacijom ili sulfacijom.[3][6]
Legalnost
Švedska agencija za javno zdravlje predložila je da se NPDPA klasificira kao opasna supstanca 1. juna 2015. Zbog tog prijedloga postao je otkazana supstanca u Švedskoj od 18. avgusta 2015.[7] Također je predložen za kontrolu u Njemačkoj prema analognim odredbama, iako one još nisu stupile na snagu od 2016.
Također pogledajte
Reference
- ^ Morris H, Wallach J (July–August 2014). "From PCP to MXE: a comprehensive review of the non-medical use of dissociative drugs". Drug Testing and Analysis. 6 (7–8): 614–32. doi:10.1002/dta.1620. PMID 24678061.
- ^ Meyer MR, Orschiedt T, Maurer HH (februar 2013). "Michaelis-Menten kinetic analysis of drugs of abuse to estimate their affinity to human P-glycoprotein". Toxicology Letters. 217 (2): 137–42. doi:10.1016/j.toxlet.2012.12.012. PMID 23273999.
- ^ a b Wink CS, Meyer GM, Wissenbach DK, Jacobsen-Bauer A, Meyer MR, Maurer HH (oktobar 2014). "Lefetamine-derived designer drugs N-ethyl-1,2-diphenylethylamine (NEDPA) and N-iso-propyl-1,2-diphenylethylamine (NPDPA): metabolism and detectability in rat urine using GC-MS, LC-MSn and LC-HR-MS/MS". Drug Testing and Analysis. 6 (10): 1038–48. doi:10.1002/dta.1621. PMID 24591097.
- ^ Wink CS, Meyer GM, Meyer MR, Maurer HH (novembar 2015). "Toxicokinetics of lefetamine and derived diphenylethylamine designer drugs-Contribution of human cytochrome P450 isozymes to their main phase I metabolic steps". Toxicology Letters. 238 (3): 39–44. doi:10.1016/j.toxlet.2015.08.012. PMID 26276083.
- ^ Beharry S, Gibbons S (oktobar 2016). "An overview of emerging and new psychoactive substances in the United Kingdom" (PDF). Forensic Science International. 267: 25–34. doi:10.1016/j.forsciint.2016.08.013. PMID 27552699.
- ^ Wink CS, Meyer GM, Zapp J, Maurer HH (februar 2015). "Lefetamine, a controlled drug and pharmaceutical lead of new designer drugs: synthesis, metabolism, and detectability in urine and human liver preparations using GC-MS, LC-MS(n), and LC-high resolution-MS/MS". Analytical and Bioanalytical Chemistry. 407 (6): 1545–57. doi:10.1007/s00216-014-8414-3. PMID 25577353.
- ^ "23 nya ämnen kan klassas som narkotika eller hälsofarlig vara" (jezik: švedski). Folkhälsomyndigheten. 1. 6. 2015. Arhivirano s originala, 17. 6. 2019. Pristupljeno 28. 1. 2021.
Content Disclaimer
Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.
- The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
- There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
- It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
- Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
- Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.
