RETSAT
| RETSAT | |||||||||||||||||||||||||
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| Identifikatori | |||||||||||||||||||||||||
| Aliasi | RETSAT | ||||||||||||||||||||||||
| Vanjski ID-jevi | OMIM: 617597 MGI: 1914692 HomoloGene: 41195 GeneCards: RETSAT | ||||||||||||||||||||||||
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| Ortolozi | |||||||||||||||||||||||||
| Vrste | Čovjek | Miš | |||||||||||||||||||||||
| Entrez | |||||||||||||||||||||||||
| Ensembl | |||||||||||||||||||||||||
| UniProt | |||||||||||||||||||||||||
| RefSeq (mRNK) | |||||||||||||||||||||||||
| RefSeq (bjelančevina) | |||||||||||||||||||||||||
| Lokacija (UCSC) | Chr 2: 85.34 – 85.35 Mb | Chr 6: 72.58 – 72.59 Mb | |||||||||||||||||||||||
| PubMed pretraga | [3] | [4] | |||||||||||||||||||||||
| Wikipodaci | |||||||||||||||||||||||||
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| Sve-trans-retinol 13,14-reduztaza | |
|---|---|
 Raspon ekspresije gena RETSAT | |
| Identifikatori | |
| Simbol | RETSAT |
| CAS broj | |
U enzimologiji, sve-trans-retinol 13,14-reduktaza (1.3.99.23) je enzim, koji je kod ljudi kodiran genom RETSAT sa hromosoma 2.[5][6][7]Katalizira hemijsku reakciju
- sve-trans-13,14-dihidroretinol + akceptor sve-trans-retinol + reducirani akceptor
Dakle, dva supstrata ovog enzima su sve-trans-13,14-dihidroretinol i akceptor, dok su njegova dva proizvoda sve-trans-retinol i reducirani akceptor. U fiziološkim uslovima, reakcija se odvija u suprotnom smjeru katalizirajući zasićenje 13-14 dvostruke veze sve-trans-retinola.
Amiokiselininska sekvenca
Dužina polipeptidnog lanca je 610 aminokiselina, a molekulska težina 66.820 Da.[8]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MWLPLVLLLA | VLLLAVLCKV | YLGLFSGSSP | NPFSEDVKRP | PAPLVTDKEA | ||||
| RKKVLKQAFS | ANQVPEKLDV | VVIGSGFGGL | AAAAILAKAG | KRVLVLEQHT | ||||
| KAGGCCHTFG | KNGLEFDTGI | HYIGRMEEGS | IGRFILDQIT | EGQLDWAPLS | ||||
| SPFDIMVLEG | PNGRKEYPMY | SGEKAYIQGL | KEKFPQEEAI | IDKYIKLVKV | ||||
| VSSGAPHAIL | LKFLPLPVVQ | LLDRCGLLTR | FSPFLQASTQ | SLAEVLQQLG | ||||
| ASSELQAVLS | YIFPTYGVTP | NHSAFSMHAL | LVNHYMKGGF | YPRGGSSEIA | ||||
| FHTIPVIQRA | GGAVLTKATV | QSVLLDSAGK | ACGVSVKKGH | ELVNIYCPIV | ||||
| VSNAGLFNTY | EHLLPGNARC | LPGVKQQLGT | VRPGLGMTSV | FICLRGTKED | ||||
| LHLPSTNYYV | YYDTDMDQAM | ERYVSMPREE | AAEHIPLLFF | AFPSAKDPTW | ||||
| EDRFPGRSTM | IMLIPTAYEW | FEEWQAELKG | KRGSDYETFK | NSFVEASMSV | ||||
| VLKLFPQLEG | KVESVTAGSP | LTNQFYLAAP | RGACYGADHD | LGRLHPCVMA | ||||
| SLRAQSPIPN | LYLTGQDIFT | CGLVGALQGA | LLCSSAILKR | NLYSDLKNLD | ||||
| SRIRAQKKKN |
Funkcija
Ovaj enzim pripada porodici oksidoreduktaza, posebno onih koji djeluju na CH-CH grupu donora sa drugim akceptorima. Sistematski naziv ove klase enzima je sve-trans-13,14-dihidroretinol:akceptor 13,14-oksidoreduktaze. Drugi nazivi u uobičajenoj upotrebi uključuju retinol saturaza, RetSat, (13,14)-sve-trans-retinol saturaza i sve-trans- retinol:sve-trans-13,14-dihidroretinol saturaza.
Gen je također nazvan PPAR-alfa-reguliranim genskim proteinom koji je izazvan gladovanjem.[9]
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000042445 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000056666 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (Oct 2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- ^ Moise AR, Kuksa V, Imanishi Y, Palczewski K (Nov 2004). "Identification of All-trans-Retinol:All-trans-13,14-dihydroretinol Saturase*". J Biol Chem. 279 (48): 50230–42. doi:10.1074/jbc.M409130200. PMC 2665716. PMID 15358783.
- ^ "Entrez Gene: RETSAT retinol saturase (all-trans-retinol 13,14-reductase)".
- ^ "UniProt, Q6NUM9" (jezik: engleski). Pristupljeno 14. 11. 2021.
- ^ "RETSAT - All-trans-retinol 13,14-reductase precursor - Homo sapiens (Human) - RETSAT gene & protein". www.uniprot.org (jezik: engleski). Pristupljeno 5. 11. 2017.
- Moise AR, Kuksa V, Imanishi Y, Palczewski K (2004). "Identification of all-trans-retinol:all-trans-13,14-dihydroretinol saturase". J. Biol. Chem. 279 (48): 50230–42. doi:10.1074/jbc.M409130200. PMC 2665716. PMID 15358783.
Dopunska literatura
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
- Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Vanjski linkovi
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