RIF1
Telomerno-pridruženi protein RIF1 jest protein koji je kod ljudi kodiran genom RIF1 sa hromosoma 2.[5][6][7]
Amiokiselininska sekvenca
Dužina polipeptidnog lanca je 2.472 aminokiseline, a molekulska 274.466 težina Da.[8]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MTARGQSPLA | PLLETLEDPS | ASHGGQTDAY | LTLTSRMTGE | EGKEVITEIE | ||||
| KKLPRLYKVL | KTHISSQNSE | LSSAALQALG | FCLYNPKITS | ELSEANALEL | ||||
| LSKLNDTIKN | SDKNVRTRAL | WVISKQTFPS | EVVGKMVSSI | IDSLEILFNK | ||||
| GETHSAVVDF | EALNVIVRLI | EQAPIQMGEE | AVRWAKLVIP | LVVHSAQKVH | ||||
| LRGATALEMG | MPLLLQKQQE | IASITEQLMT | TKLISELQKL | FMSKNETYVL | ||||
| KLWPLFVKLL | GRTLHRSGSF | INSLLQLEEL | GFRSGAPMIK | KIAFIAWKSL | ||||
| IDNFALNPDI | LCSAKRLKLL | MQPLSSIHVR | TETLALTKLE | VWWYLLMRLG | ||||
| PHLPANFEQV | CVPLIQSTIS | IDSNASPQGN | SCHVATSPGL | NPMTPVHKGA | ||||
| SSPYGAPGTP | RMNLSSNLGG | MATIPSIQLL | GLEMLLHFLL | GPEALSFAKQ | ||||
| NKLVLSLEPL | EHPLISSPSF | FSKHANTLIT | AVHDSFVAVG | KDAPDVVVSA | ||||
| IWKELISLVK | SVTESGNKKE | KPGSEVLTLL | LKSLESIVKS | EVFPVSKTLV | ||||
| LMEITIKGLP | QKVLGSPAYQ | VANMDILNGT | PALFLIQLIF | NNFLECGVSD | ||||
| ERFFLSLESL | VGCVLSGPTS | PLAFSDSVLN | VINQNAKQLE | NKEHLWKMWS | ||||
| VIVTPLTELI | NQTNEVNQGD | ALEHNFSAIY | GALTLPVNHI | FSEQRFPVAT | ||||
| MKTLLRTWSE | LYRAFARCAA | LVATAEENLC | CEELSSKIMS | SLEDEGFSNL | ||||
| LFVDRIIYII | TVMVDCIDFS | PYNIKYQPKV | KSPQRPSDWS | KKKNEPLGKL | ||||
| TSLFKLIVKV | IYSFHTLSFK | EAHSDTLFTI | GNSITGIISS | VLGHISLPSM | ||||
| IRKIFATLTR | PLALFYENSK | LDEVPKVYSC | LNNKLEKLLG | EIIACLQFSY | ||||
| TGTYDSELLE | QLSPLLCIIF | LHKNKQIRKQ | SAQFWNATFA | KVMMLVYPEE | ||||
| LKPVLTQAKQ | KFLLLLPGLE | TVEMMEESSG | PYSDGTENSQ | LNVKISGMER | ||||
| KSNGKRDSFL | AQTKNKKENM | KPAAKLKLES | SSLKVKGEIL | LEEEKSTDFV | ||||
| FIPPEGKDAK | ERILTDHQKE | VLKTKRCDIP | AMYNNLDVSQ | DTLFTQYSQE | ||||
| EPMEIPTLTR | KPKEDSKMMI | TEEQMDSDIV | IPQDVTEDCG | MAEHLEKSSL | ||||
| SNNECGSLDK | TSPEMSNSNN | DERKKALISS | RKTSTECASS | TENSFVVSSS | ||||
| SVSNTTVAGT | PPYPTSRRQT | FITLEKFDGS | ENRPFSPSPL | NNISSTVTVK | ||||
| NNQETMIKTD | FLPKAKQREG | TFSKSDSEKI | VNGTKRSSRR | AGKAEQTGNK | ||||
| RSKPLMRSEP | EKNTEESVEG | IVVLENNPPG | LLNQTECVSD | NQVHLSESTM | ||||
| EHDNTKLKAA | TVENAVLLET | NTVEEKNVEI | NLESKENTPP | VVISADQMVN | ||||
| EDSQVQITPN | QKTLRRSSRR | RSEVVESTTE | SQDKENSHQK | KERRKEEEKP | ||||
| LQKSPLHIKD | DVLPKQKLIA | EQTLQENLIE | KGSNLHEKTL | GETSANAETE | ||||
| QNKKKADPEN | IKSEGDGTQD | IVDKSSEKLV | RGRTRYQTRR | ASQGLLSSIE | ||||
| NSESDSSEAK | EEGSRKKRSG | KWKNKSNESV | DIQDQEEKVV | KQECIKAENQ | ||||
| SHDYKATSEE | DVSIKSPICE | KQDESNTVIC | QDSTVTSDLL | QVPDDLPNVC | ||||
| EEKNETSKYA | EYSFTSLPVP | ESNLRTRNAI | KRLHKRDSFD | NCSLGESSKI | ||||
| GISDISSLSE | KTFQTLECQH | KRSRRVRRSK | GCDCCGEKSQ | PQEKSLIGLK | ||||
| NTENNDVEIS | ETKKADVQAP | VSPSETSQAN | PYSEGQFLDE | HHSVNFHLGL | ||||
| KEDNDTINDS | LIVSETKSKE | NTMQESLPSG | IVNFREEICD | MDSSEAMSLE | ||||
| SQESPNENFK | TVGPCLGDSK | NVSQESLETK | EEKPEETPKM | ELSLENVTVE | ||||
| GNACKVTESN | LEKAKTMELN | VGNEASFHGQ | ERTKTGISEE | AAIEENKRND | ||||
| DSEADTAKLN | AKEVATEEFN | SDISLSDNTT | PVKLNAQTEI | SEQTAAGELD | ||||
| GGNDVSDLHS | SEETNTKMKN | NEEMMIGEAM | AETGHDGETE | NEGITTKTSK | ||||
| PDEAETNMLT | AEMDNFVCDT | VEMSTEEGII | DANKTETNTE | YSKSEEKLDN | ||||
| NQMVMESDIL | QEDHHTSQKV | EEPSQCLASG | TAISELIIED | NNASPQKLRE | ||||
| LDPSLVSAND | SPSGMQTRCV | WSPLASPSTS | ILKRGLKRSQ | EDEISSPVNK | ||||
| VRRVSFADPI | YQAGLADDID | RRCSIVRSHS | SNSSPIGKSV | KTSPTTQSKH | ||||
| NTTSAKGFLS | PGSRSPKFKS | SKKCLISEMA | KESIPCPTES | VYPPLVNCVA | ||||
| PVDIILPQIT | SNMWARGLGQ | LIRAKNIKTI | GDLSTLTASE | IKTLPIRSPK | ||||
| VSNVKKALRI | YHEQQVKTRG | LEEIPVFDIS | EKTVNGIENK | SLSPDEERLV | ||||
| SDIIDPVALE | IPLSKNLLAQ | ISALALQLDS | EDLHNYSGSQ | LFEMHEKLSC | ||||
| MANSVIKNLQ | SRWRSPSHEN | SI |
Funkcija
RIF1 i RIF2 zatvaraju krajeve hromosoma (telomere) u kvascima.[9] Kod viših eukariota, Rif1 je uključen u odgovor na oštećenje DNK, organizaciju hromatinske arhitekture i regulaciju vremena replikacije. Pokazalo se da se RIF1 u jedru vezuje za RNK .[10]
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000080345 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036202 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Silverman J, Takai H, Buonomo SB, Eisenhaber F, de Lange T (septembar 2004). "Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint". Genes & Development. 18 (17): 2108–19. doi:10.1101/gad.1216004. PMC 515289. PMID 15342490.
- ^ Adams IR, McLaren A (april 2004). "Identification and characterisation of mRif1: a mouse telomere-associated protein highly expressed in germ cells and embryo-derived pluripotent stem cells". Developmental Dynamics. 229 (4): 733–44. doi:10.1002/dvdy.10471. PMID 15042697. S2CID 22138565.
- ^ "Entrez Gene: RIF1 RAP1 interacting factor homolog (yeast)".
- ^ "UniProt, Q5UIP0" (jezik: ebg.). Pristupljeno 18. 11. 2021.CS1 održavanje: nepoznati jezik (link)
- ^ Ribeyre C, Shore D (2012). "Anticheckpoint pathways at telomeres in yeast". Nature Structural & Molecular Biology. 19 (3): 307–13. doi:10.1038/nsmb.2225. PMID 22343724. S2CID 10636976.
- ^ Conrad T, Albrecht AS, de Melo Costa VR, Sauer S, Meierhofer D, Ørom UA (1. 1. 2016). "Serial interactome capture of the human cell nucleus". Nature Communications. 7: 11212. Bibcode:2016NatCo...711212C. doi:10.1038/ncomms11212. PMC 4822031. PMID 27040163.
Dopunska literatura
- Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (april 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
- Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (april 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
- Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (august 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
- Xu L, Blackburn EH (decembar 2004). "Human Rif1 protein binds aberrant telomeres and aligns along anaphase midzone microtubules". The Journal of Cell Biology. 167 (5): 819–30. doi:10.1083/jcb.200408181. PMC 2172464. PMID 15583028.
- Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (oktobar 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
- Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (novembar 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
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