SARDH
| SARDH | |||||||||||||||||||||||||
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| Identifikatori | |||||||||||||||||||||||||
| Aliasi | SARDH | ||||||||||||||||||||||||
| Vanjski ID-jevi | OMIM: 604455 MGI: 2183102 HomoloGene: 5149 GeneCards: SARDH | ||||||||||||||||||||||||
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| Ortolozi | |||||||||||||||||||||||||
| Vrste | Čovjek | Miš | |||||||||||||||||||||||
| Entrez | |||||||||||||||||||||||||
| Ensembl | |||||||||||||||||||||||||
| UniProt | |||||||||||||||||||||||||
| RefSeq (mRNK) | |||||||||||||||||||||||||
| RefSeq (bjelančevina) | |||||||||||||||||||||||||
| Lokacija (UCSC) | Chr 9: 133.66 – 133.74 Mb | Chr 2: 27.08 – 27.14 Mb | |||||||||||||||||||||||
| PubMed pretraga | [3] | [4] | |||||||||||||||||||||||
| Wikipodaci | |||||||||||||||||||||||||
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Mitohondrijska sarkozin-dehidrogenaza je enzim koji je kod ljudi kodiran genom SARDH.[5][6]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 918 aminokiselina, а molekulska težina 101.037 Da.[7]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MASLSRALRV | AAAHPRQSPT | RGMGPCNLSS | AAGPTAEKSV | PYQRTLKEGQ | ||||
| GTSVVAQGPS | RPLPSTANVV | VIGGGSLGCQ | TLYHLAKLGM | SGAVLLERER | ||||
| LTSGTTWHTA | GLLWQLRPSD | VEVELLAHTR | RVVSRELEEE | TGLHTGWIQN | ||||
| GGLFIASNRQ | RLDEYKRLMS | LGKAYGVESH | VLSPAETKTL | YPLMNVDDLY | ||||
| GTLYVPHDGT | MDPAGTCTTL | ARAASARGAQ | VIENCPVTGI | RVWTDDFGVR | ||||
| RVAGVETQHG | SIQTPCVVNC | AGVWASAVGR | MAGVKVPLVA | MHHAYVVTER | ||||
| IEGIQNMPNV | RDHDASVYLR | LQGDALSVGG | YEANPIFWEE | VSDKFAFGLF | ||||
| DLDWEVFTQH | IEGAINRVPV | LEKTGIKSTV | CGPESFTPDH | KPLMGEAPEL | ||||
| RGFFLGCGFN | SAGMMLGGGC | GQELAHWIIH | GRPEKDMHGY | DIRRFHHSLT | ||||
| DHPRWIRERS | HESYAKNYSV | VFPHDEPLAG | RNMRRDPLHE | ELLGQGCVFQ | ||||
| ERHGWERPGW | FHPRGPAPVL | EYDYYGAYGS | RAHEDYAYRR | LLADEYTFAF | ||||
| PPHHDTIKKE | CLACRGAAAV | FDMSYFGKFY | LVGLDARKAA | DWLFSADVSR | ||||
| PPGSTVYTCM | LNHRGGTESD | LTVSRLAPSH | QASPLAPAFE | GDGYYLAMGG | ||||
| AVAQHNWSHI | TTVLQDQKSQ | CQLIDSSEDL | GMISIQGPAS | RAILQEVLDA | ||||
| DLSNEAFPFS | THKLLRAAGH | LVRAMRLSFV | GELGWELHIP | KASCVPVYRA | ||||
| VMAAGAKHGL | INAGYRAIDS | LSIEKGYRHW | HADLRPDDSP | LEAGLAFTCK | ||||
| LKSPVPFLGR | EALEQQRAAG | LRRRLVCFTM | EDKVPMFGLE | AIWRNGQVVG | ||||
| HVRRADFGFA | IDKTIAYGYI | HDPSGGPVSL | DFVKSGDYAL | ERMGVTYGAQ | ||||
| AHLKSPFDPN | NKRVKGIY |
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000123453 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000009614 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Eschenbrenner M, Jorns MS (Nov 1999). "Cloning and mapping of the cDNA for human sarcosine dehydrogenase, a flavoenzyme defective in patients with sarcosinemia". Genomics. 59 (3): 300–8. doi:10.1006/geno.1999.5886. PMID 10444331.
- ^ "Entrez Gene: SARDH sarcosine dehydrogenase".
- ^ "UniProt, Q9UL12". Pristupljeno 11. 9. 2021.
Dopunska literatura
- Porter DH, Cook RJ, Wagner C (1986). "Enzymatic properties of dimethylglycine dehydrogenase and sarcosine dehydrogenase from rat liver". Arch. Biochem. Biophys. 243 (2): 396–407. doi:10.1016/0003-9861(85)90516-8. PMID 2417560.
- London RE, Gabel SA, Funk A (1988). "Metabolism of excess methionine in the liver of intact rat: an in vivo 2H NMR study". Biochemistry. 26 (22): 7166–72. doi:10.1021/bi00396a044. PMID 2447942.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Bergeron F, Otto A, Blache P, et al. (1998). "Molecular cloning and tissue distribution of rat sarcosine dehydrogenase". Eur. J. Biochem. 257 (3): 556–61. doi:10.1046/j.1432-1327.1998.2570556.x. PMID 9839943.
- Gilbert JR, Kumar A, Newey S, et al. (2000). "Physical and cDNA mapping in the DBH region of human chromosome 9q34". Hum. Hered. 50 (3): 151–7. doi:10.1159/000022905. PMID 10686491. S2CID 43238824.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Vanjski linkovi
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