SLU7
Pre-iRNK-splajsing faktor SLU7 jest protein koji je kod ljudi kodiran genom SLU7 sa hromosoma 5.[5][6][7]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 586 aminokiselina, а molekulska težina 68.387 Da.[8]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MSATVVDAVN | AAPLSGSKEM | SLEEPKKMTR | EDWRKKKELE | EQRKLGNAPA | ||||
| EVDEEGKDIN | PHIPQYISSV | PWYIDPSKRP | TLKHQRPQPE | KQKQFSSSGE | ||||
| WYKRGVKENS | IITKYRKGAC | ENCGAMTHKK | KDCFERPRRV | GAKFTGTNIA | ||||
| PDEHVQPQLM | FDYDGKRDRW | NGYNPEEHMK | IVEEYAKVDL | AKRTLKAQKL | ||||
| QEELASGKLV | EQANSPKHQW | GEEEPNSQME | KDHNSEDEDE | DKYADDIDMP | ||||
| GQNFDSKRRI | TVRNLRIRED | IAKYLRNLDP | NSAYYDPKTR | AMRENPYANA | ||||
| GKNPDEVSYA | GDNFVRYTGD | TISMAQTQLF | AWEAYDKGSE | VHLQADPTKL | ||||
| ELLYKSFKVK | KEDFKEQQKE | SILEKYGGQE | HLDAPPAELL | LAQTEDYVEY | ||||
| SRHGTVIKGQ | ERAVACSKYE | EDVKIHNHTH | IWGSYWKEGR | WGYKCCHSFF | ||||
| KYSYCTGEAG | KEIVNSEECI | INEITGEESV | KKPQTLMELH | QEKLKEEKKK | ||||
| KKKKKKKHRK | SSSDSDDEEK | KHEKLKKALN | AEEARLLHVK | ETMQIDERKR | ||||
| PYNSMYETRE | PTEEEMEAYR | MKRQRPDDPM | ASFLGQ |
Funkcija
Splajsing pre-iRNK događa se u dva uzastopna transesterifikacijska koraka. Protein kodiran ovim genom je faktor prerade, za koji je utvrđeno da je neophodan tokom drugog katalitskog koraka u procesu prerade pre-iRNK. Povezuje se sa splajsosomom i sadrži motiv cinkovog zgloba, koji se nalazi u drugim faktorima splajsinga i uključen je u interakcije protein-proteini protein-nukleinske kiseline.[7]
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000164609 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020409 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Chua K, Reed R (maj 1999). "Human step II splicing factor hSlu7 functions in restructuring the spliceosome between the catalytic steps of splicing". Genes Dev. 13 (7): 841–50. doi:10.1101/gad.13.7.841. PMC 316594. PMID 10197984.
- ^ Shomron N, Alberstein M, Reznik M, Ast G (Mar 2005). "Stress alters the subcellular distribution of hSlu7 and thus modulates alternative splicing". J Cell Sci. 118 (Pt 6): 1151–9. doi:10.1242/jcs.01720. PMID 15728250.
- ^ a b "Entrez Gene: SLU7 SLU7 splicing factor homolog (S. cerevisiae)".
- ^ "UniProt, O95391" (jezik: engleski). Pristupljeno 20. 10. 2021.
Dopunska literatura
- Alberstein M, Amit M, Vaknin K, et al. (2008). "Regulation of transcription of the RNA splicing factor hSlu7 by Elk-1 and Sp1 affects alternative splicing". RNA. 13 (11): 1988–99. doi:10.1261/rna.492907. PMC 2040095. PMID 17804646.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
- Shomron N, Reznik M, Ast G (2005). "Splicing factor hSlu7 contains a unique functional domain required to retain the protein within the nucleus". Mol. Biol. Cell. 15 (8): 3782–95. doi:10.1091/mbc.E04-02-0152. PMC 491837. PMID 15181151.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Chua K, Reed R (2001). "An upstream AG determines whether a downstream AG is selected during catalytic step II of splicing". Mol. Cell. Biol. 21 (5): 1509–14. doi:10.1128/MCB.21.5.1509-1514.2001. PMC 86697. PMID 11238888.
- Chua K, Reed R (2000). "The RNA splicing factor hSlu7 is required for correct 3' splice-site choice". Nature. 402 (6758): 207–10. doi:10.1038/46086. PMID 10647016. S2CID 4428185.
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Index:
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