SRCAP
Helikaza SRCAP je enzim koji je kod ljudi kodiran genom SRCAP.[5][6][7]
Pomoći radiajacijske hibridne analize, Nagase et al. (1997) mapirali su gen SRCAP na hromosomu 16.[8]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 3.230 aminokiselina, a molekulska težina 343.555 Da.[9].
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MQSSPSPAHP | QLPVLQTQMV | SDGMTGSNPV | SPASSSSPAS | SGAGGISPQH | ||||
| IAQDSSLDGP | PGPPDGATVP | LEGFSLSQAA | DLANKGPKWE | KSHAEIAEQA | ||||
| KHEAEIETRI | AELRKEGFWS | LKRLPKVPEP | PRPKGHWDYL | CEEMQWLSAD | ||||
| FAQERRWKRG | VARKVVRMVI | RHHEEQRQKE | ERARREEQAK | LRRIASTMAK | ||||
| DVRQFWSNVE | KVVQFKQQSR | LEEKRKKALD | LHLDFIVGQT | EKYSDLLSQS | ||||
| LNQPLTSSKA | GSSPCLGSSS | AASSPPPPAS | RLDDEDGDFQ | PQEDEEEDDE | ||||
| ETIEVEEQQE | GNDAEAQRRE | IELLRREGEL | PLEELLRSLP | PQLLEGPSSP | ||||
| SQTPSSHDSD | TRDGPEEGAE | EEPPQVLEIK | PPPSAVTQRN | KQPWHPDEDD | ||||
| EEFTANEEEA | EDEEDTIAAE | EQLEGEVDHA | MELSELAREG | ELSMEELLQQ | ||||
| YAGAYAPGSG | SSEDEDEDEV | DANSSDCEPE | GPVEAEEPPQ | EDSSSQSDSV | ||||
| EDRSEDEEDE | HSEEEETSGS | SASEESESEE | SEDAQSQSQA | DEEEEDDDFG | ||||
| VEYLLARDEE | QSEADAGSGP | PTPGPTTLGP | KKEITDIAAA | AESLQPKGYT | ||||
| LATTQVKTPI | PLLLRGQLRE | YQHIGLDWLV | TMYEKKLNGI | LADEMGLGKT | ||||
| IQTISLLAHL | ACEKGNWGPH | LIIVPTSVML | NWEMELKRWC | PSFKILTYYG | ||||
| AQKERKLKRQ | GWTKPNAFHV | CITSYKLVLQ | DHQAFRRKNW | RYLILDEAQN | ||||
| IKNFKSQRWQ | SLLNFNSQRR | LLLTGTPLQN | SLMELWSLMH | FLMPHVFQSH | ||||
| REFKEWFSNP | LTGMIEGSQE | YNEGLVKRLH | KVLRPFLLRR | VKVDVEKQMP | ||||
| KKYEHVIRCR | LSKRQRCLYD | DFMAQTTTKE | TLATGHFMSV | INILMQLRKV | ||||
| CNHPNLFDPR | PVTSPFITPG | ICFSTASLVL | RATDVHPLQR | IDMGRFDLIG | ||||
| LEGRVSRYEA | DTFLPRHRLS | RRVLLEVATA | PDPPPRPKPV | KMKVNRMLQP | ||||
| VPKQEGRTVV | VVNNPRAPLG | PVPVRPPPGP | ELSAQPTPGP | VPQVLPASLM | ||||
| VSASPAGPPL | IPASRPPGPV | LLPPLQPNSG | SLPQVLPSPL | GVLSGTSRPP | ||||
| TPTLSLKPTP | PAPVRLSPAP | PPGSSSLLKP | LTVPPGYTFP | PAAATTTSTT | ||||
| TATATTTAVP | APTPAPQRLI | LSPDMQARLP | SGEVVSIGQL | ASLAQRPVAN | ||||
| AGGSKPLTFQ | IQGNKLTLTG | AQVRQLAVGQ | PRPLQRNVVH | LVSAGGQHHL | ||||
| ISQPAHVALI | QAVAPTPGPT | PVSVLPSSTP | STTPAPTGLS | LPLAANQVPP | ||||
| TMVNNTGVVK | IVVRQAPRDG | LTPVPPLAPA | PRPPSSGLPA | VLNPRPTLTP | ||||
| GRLPTPTLGT | ARAPMPTPTL | VRPLLKLVHS | PSPEVSASAP | GAAPLTISSP | ||||
| LHVPSSLPGP | ASSPMPIPNS | SPLASPVSST | VSVPLSSSLP | ISVPTTLPAP | ||||
| ASAPLTIPIS | APLTVSASGP | ALLTSVTPPL | APVVPAAPGP | PSLAPSGASP | ||||
| SASALTLGLA | TAPSLSSSQT | PGHPLLLAPT | SSHVPGLNST | VAPACSPVLV | ||||
| PASALASPFP | SAPNPAPAQA | SLLAPASSAS | QALATPLAPM | AAPQTAILAP | ||||
| SPAPPLAPLP | VLAPSPGAAP | VLASSQTPVP | VMAPSSTPGT | SLASASPVPA | ||||
| PTPVLAPSST | QTMLPAPVPS | PLPSPASTQT | LALAPALAPT | LGGSSPSQTL | ||||
| SLGTGNPQGP | FPTQTLSLTP | ASSLVPTPAQ | TLSLAPGPPL | GPTQTLSLAP | ||||
| APPLAPASPV | GPAPAHTLTL | APASSSASLL | APASVQTLTL | SPAPVPTLGP | ||||
| AAAQTLALAP | ASTQSPASQA | SSLVVSASGA | APLPVTMVSR | LPVSKDEPDT | ||||
| LTLRSGPPSP | PSTATSFGGP | RPRRQPPPPP | RSPFYLDSLE | EKRKRQRSER | ||||
| LERIFQLSEA | HGALAPVYGT | EVLDFCTLPQ | PVASPIGPRS | PGPSHPTFWT | ||||
| YTEAAHRAVL | FPQQRLDQLS | EIIERFIFVM | PPVEAPPPSL | HACHPPPWLA | ||||
| PRQAAFQEQL | ASELWPRARP | LHRIVCNMRT | QFPDLRLIQY | DCGKLQTLAV | ||||
| LLRQLKAEGH | RVLIFTQMTR | MLDVLEQFLT | YHGHLYLRLD | GSTRVEQRQA | ||||
| LMERFNADKR | IFCFILSTRS | GGVGVNLTGA | DTVVFYDSDW | NPTMDAQAQD | ||||
| RCHRIGQTRD | VHIYRLISER | TVEENILKKA | NQKRMLGDMA | IEGGNFTTAY | ||||
| FKQQTIRELF | DMPLEEPSSS | SVPSAPEEEE | ETVASKQTHI | LEQALCRAED | ||||
| EEDIRAATQA | KAEQVAELAE | FNENDGFPAG | EGEEAGRPGA | EDEEMSRAEQ | ||||
| EIAALVEQLT | PIERYAMKFL | EASLEEVSRE | ELKQAEEQVE | AARKDLDQAK | ||||
| EEVFRLPQEE | EEGPGAGDES | SCGTGGGTHR | RSKKAKAPER | PGTRVSERLR | ||||
| GARAETQGAN | HTPVISAHQT | RSTTTPPRCS | PARERVPRPA | PRPRPTPASA | ||||
| PAAIPALVPV | PVSAPVPISA | PNPITILPVH | ILPSPPPPSQ | IPPCSSPACT | ||||
| PPPACTPPPA | HTPPPAQTCL | VTPSSPLLLG | PPSVPISASV | TNLPLGLRPE | ||||
| AELCAQALAS | PESLELASVA | SSETSSLSLV | PPKDLLPVAV | EILPVSEKNL | ||||
| SLTPSAPSLT | LEAGSIPNGQ | EQEAPDSAEG | TTLTVLPEGE | ELPLCVSESN | ||||
| GLELPPSAAS | DEPLQEPLEA | DRTSEELTEA | KTPTSSPEKP | QELVTAEVAA | ||||
| PSTSSSATSS | PEGPSPARPP | RRRTSADVEI | RGQGTGRPGQ | PPGPKVLRKL | ||||
| PGRLVTVVEE | KELVRRRRQQ | RGAASTLVPG | VSETSASPGS | PSVRSMSGPE | ||||
| SSPPIGGPCE | AAPSSSLPTP | PQQPFIARRH | IELGVTGGGS | PENGDGALLA | ||||
| ITPPAVKRRR | GRPPKKNRSP | ADAGRGVDEA | PSSTLKGKTN | GADPVPGPET | ||||
| LIVADPVLEP | QLIPGPQPLG | PQPVHRPNPL | LSPVEKRRRG | RPPKARDLPI | ||||
| PGTISSAGDG | NSESRTQPPP | HPSPLTPLPP | LLVCPTATVA | NTVTTVTIST | ||||
| SPPKRKRGRP | PKNPPSPRPS | QLPVLDRDST | SVLESCGLGR | RRQPQGQGES | ||||
| EGSSSDEDGS | RPLTRLARLR | LEAEGMRGRK | SGGSMVVAVI | QDDLDLADSG | ||||
| PGGLELTPPV | VSLTPKLRST | RLRPGSLVPP | LETEKLPRKR | AGAPVGGSPG | ||||
| LAKRGRLQPP | SPLGPEGSVE | ESEAEASGEE | EEGDGTPRRR | PGPRRLVGTT | ||||
| NQGDQRILRS | SAPPSLAGPA | VSHRGRKAKT |
- Simboli
C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000080603 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053877 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Johnston H, Kneer J, Chackalaparampil I, Yaciuk P, Chrivia J (Jul 1999). "Identification of a novel SNF2/SWI2 protein family member, SRCAP, which interacts with CREB-binding protein". J Biol Chem. 274 (23): 16370–6. doi:10.1074/jbc.274.23.16370. PMID 10347196.
- ^ Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Sep 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
- ^ "Entrez Gene: SRCAP Snf2-related CBP activator protein".
- ^ Nagase, T., Ishikawa, K., Nakajima, D., Ohira, M., Seki, N., Miyajima, N., Tanaka, A., Kotani, H., Nomura, N., Ohara, O. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. DNA Res. 4: 141-150, 1997. PubMed: 9205841
- ^ "UniProt, Q6ZRS2". Pristupljeno 9. 7. 2021.
Dopunska literatura
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Ghosh AK, Majumder M, Steele R, et al. (2000). "Hepatitis C virus NS5A protein modulates transcription through a novel cellular transcription factor SRCAP". J. Biol. Chem. 275 (10): 7184–8. doi:10.1074/jbc.275.10.7184. PMID 10702287.
- Xu X, Chackalaparampil I, Monroy MA, et al. (2001). "Adenovirus DNA binding protein interacts with the SNF2-related CBP activator protein (SrCap) and inhibits SrCap-mediated transcription". J. Virol. 75 (21): 10033–40. doi:10.1128/JVI.75.21.10033-10040.2001. PMC 114578. PMID 11581372.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Monroy MA, Schott NM, Cox L, et al. (2004). "SNF2-related CBP activator protein (SRCAP) functions as a coactivator of steroid receptor-mediated transcription through synergistic interactions with CARM-1 and GRIP-1". Mol. Endocrinol. 17 (12): 2519–28. doi:10.1210/me.2003-0208. PMID 14500758.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Cai Y, Jin J, Florens L, et al. (2005). "The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes". J. Biol. Chem. 280 (14): 13665–70. doi:10.1074/jbc.M500001200. PMID 15647280.
- Eissenberg JC, Wong M, Chrivia JC (2005). "Human SRCAP and Drosophila melanogaster DOM are homologs that function in the notch signaling pathway". Mol. Cell. Biol. 25 (15): 6559–69. doi:10.1128/MCB.25.15.6559-6569.2005. PMC 1190335. PMID 16024792.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Ruhl DD, Jin J, Cai Y, et al. (2006). "Purification of a human SRCAP complex that remodels chromatin by incorporating the histone variant H2A.Z into nucleosomes". Biochemistry. 45 (17): 5671–7. doi:10.1021/bi060043d. PMID 16634648.
- Cai Y, Jin J, Gottschalk AJ, et al. (2007). "Purification and assay of the human INO80 and SRCAP chromatin remodeling complexes". Methods. 40 (4): 312–7. doi:10.1016/j.ymeth.2006.06.023. PMC 3092633. PMID 17101442.
- Wong MM, Cox LK, Chrivia JC (2007). "The chromatin remodeling protein, SRCAP, is critical for deposition of the histone variant H2A.Z at promoters". J. Biol. Chem. 282 (36): 26132–9. doi:10.1074/jbc.M703418200. PMID 17617668.
Vanjski linkovi
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Index:
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