Ovaj gen kodira endopeptidazu koja cijepa specifične supstrate slijedeći aspartatne ostatke Kodirani protein prolazi posttranslacijsku autoproteolitsku obradu da bi se generirale alfa i beta podjedinice, koje se ponovno okupljaju u aktivni alfa2-beta2 heterotetramer. Potrebno je cijepati MLL, protein potreban za održavanje ekspresije gena HOX i TFIIA, bazni faktor transkripcije. Utvrđeno je da cijepanje transkripcijskog faktora II A pokreće spermatogenezu.[7]
Opisane su alternativno prerađene varijante transkripta, ali njihova biološka valjanost nije utvrđena.[6]
Taspaza1 je prekomjerno izražena u primarnim ljudskim karcinomima i funkcionira kao neonkogen ovisna proteaza, koja koordinira karcinomskuproliferaciju ćelija i apoptozu. Zato taspaza 1 može poslužiti kao nova terapijska meta protiv raka.[8]
Khan JA, Dunn BM, Tong L (2006). "Crystal structure of human Taspase1, a crucial protease regulating the function of MLL". Structure. 13 (10): 1443–52. doi:10.1016/j.str.2005.07.006. PMID16216576.
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