TDGF1
Transmembranski protein 158 jest protein koji je kod ljudi kodiran genom TMEM158 sa hromosoma 3.[5][6][7]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 300 aminokiselina, а molekulska težina 30.404 Da.[8].
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MLPLLAALLA | AACPLPPVRG | GAADAPGLLG | VPSNASVNAS | SADEPIAPRL | ||||
| LASAAPGPPE | RPGPEEAAAA | AAPCNISVQR | QMLSSLLVRW | GRPRGFQCDL | ||||
| LLFSTNAHGR | AFFAAAFHRV | GPPLLIEHLG | LAAGGAQQDL | RLCVGCGWVR | ||||
| GRRTGRLRPA | AAPSAAAATA | GAPTALPAYP | AAEPPGPLWL | QGEPLHFCCL | ||||
| DFSLEELQGE | PGWRLNRKPI | ESTLVACFMT | LVIVVWSVAA | LIWPVPIIAG | ||||
| FLPNGMEQRR | TTASTTAATP | AAVPAGTTAA | AAAAAAAAAA | AAVTSGVATK | ||||
Funkcija
Kodirani protein je sličan pacovskom receptoru ćelijske površine za koji je predloženo da funkcionira u neuronskom putu preživljavanja[7]
Konstitutivna aktivacija Ras puta pokreće ireverzibilno zaustavljanje proliferacije koje podsjeća na replikativnu senescenciju. Transkripcija ovog gena je pojačana kao odgovor na aktivaciju Ras puta, ali ne pod drugim uvjetima koji induciraju starenje .
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000241186 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032494 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Hama T, Maruyama M, Katoh-Semba R, Takizawa M, Iwashima M, Nara K (Aug 2001). "Identification and molecular cloning of a novel brain-specific receptor protein that binds to brain injury-derived neurotrophic peptide. Possible role for neuronal survival". J Biol Chem. 276 (34): 31929–35. doi:10.1074/jbc.M100617200. PMID 11399754.
- ^ Barradas M, Gonos ES, Zebedee Z, Kolettas E, Petropoulou C, Delgado MD, Leon J, Hara E, Serrano M (Feb 2002). "Identification of a candidate tumor-suppressor gene specifically activated during Ras-induced senescence". Exp Cell Res. 273 (2): 127–37. doi:10.1006/excr.2001.5434. PMID 11822868.
- ^ a b "Entrez Gene: TMEM158 transmembrane protein 158".
- ^ "UniProt, Q8WZ71" (jezik: eng). Pristupljeno 6. 11. 2021.CS1 održavanje: nepoznati jezik (link)
Dopunska literatura
- Iglesias D, Fernández-Peralta AM, Nejda N, et al. (2006). "RIS1, a gene with trinucleotide repeats, is a target in the mutator pathway of colorectal carcinogenesis". Cancer Genet. Cytogenet. 167 (2): 138–44. doi:10.1016/j.cancergencyto.2005.12.002. PMID 16737913.
- Zirn B, Samans B, Wittmann S, et al. (2006). "Target genes of the WNT/beta-catenin pathway in Wilms tumors". Genes Chromosomes Cancer. 45 (6): 565–74. doi:10.1002/gcc.20319. PMID 16575872. S2CID 84406946.
- Silva J, Silva JM, Barradas M, et al. (2006). "Analysis of the candidate tumor suppressor Ris-1 in primary human breast carcinomas". Mutat. Res. 594 (1–2): 78–85. doi:10.1016/j.mrfmmm.2005.07.017. PMID 16280139.
- Sussan TE, Pletcher MT, Murakami Y, Reeves RH (2006). "Tumor suppressor in lung cancer 1 (TSLC1) alters tumorigenic growth properties and gene expression". Mol. Cancer. 4: 28. doi:10.1186/1476-4598-4-28. PMC 1208945. PMID 16083501.
- Verlinden I, Janssens J, Raus J, Michiels L (2005). "Microdissection and SAGE as a combined tool to reveal gene expression in ductal carcinoma in situ of the breast". Mol. Carcinog. 41 (4): 197–206. doi:10.1002/mc.20055. PMID 15486950. S2CID 19850341.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
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Index:
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