TTI2
| TTI2 | |||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||||||||||||||||
| Aliasi | TTI2 | ||||||||||||||||||||||||
| Vanjski ID-jevi | OMIM: 614426 MGI: 2384576 HomoloGene: 11836 GeneCards: TTI2 | ||||||||||||||||||||||||
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| Ortolozi | |||||||||||||||||||||||||
| Vrste | Čovjek | Miš | |||||||||||||||||||||||
| Entrez | |||||||||||||||||||||||||
| Ensembl | |||||||||||||||||||||||||
| UniProt | |||||||||||||||||||||||||
| RefSeq (mRNK) | |||||||||||||||||||||||||
| RefSeq (bjelančevina) | |||||||||||||||||||||||||
| Lokacija (UCSC) | Chr 8: 33.47 – 33.51 Mb | Chr 8: 31.64 – 31.65 Mb | |||||||||||||||||||||||
| PubMed pretraga | [3] | [4] | |||||||||||||||||||||||
| Wikipodaci | |||||||||||||||||||||||||
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TELO2 interaktivni protein 2 je protein koji je kod ljudi kodiran genom TTI2 .[5]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 508 aminokiselina, а molekulska težina 56.915 Da.[6]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MELDSALEAP | SQEDSNLSEE | LSHSAFGQAF | SKILHCLARP | EARRGNVKDA | ||||
| VLKDLGDLIE | ATEFDRLFEG | TGARLRGMPE | TLGQVAKALE | KYAAPSKEEE | ||||
| GGGDGHSEAA | EKAAQVGLLF | LKLLGKVETA | KNSLVGPAWQ | TGLHHLAGPV | ||||
| YIFAITHSLE | QPWTTPRSRE | VAREVLTSLL | QVTECGSVAG | FLHGENEDEK | ||||
| GRLSVILGLL | KPDLYKESWK | NNPAIKHVFS | WTLQQVTRPW | LSQHLERVLP | ||||
| ASLVISDDYQ | TENKILGVHC | LHHIVLNVPA | ADLLQYNRAQ | VLYHAISNHL | ||||
| YTPEHHLIQA | VLLCLLDLFP | ILEKTLHWKG | DGARPTTHCD | EVLRLILTHM | ||||
| EPEHRLLLRR | TYARNLPAFV | NRLGILTVRH | LKRLERVIIG | YLEVYDGPEE | ||||
| EARLKILETL | KLLMQHTWPR | VSCRLVVLLK | ALLKLICDVA | RDPNLTPESV | ||||
| KSALLQEATD | CLILLDRCSQ | GRVKGLLAKI | PQSCEDRKVV | NYIRKVQQVS | ||||
| EGAPYNGT |
Funkcija
Ovaj gen kodira regulator odgovora na oštećenje DNK. Protein je komponenta trostrukog T-kompleksa (TTT) koji takođe uključuje telomerne proteine za regulaciju dužine i TELO2 protein u interakciji 1.
TTT kompleks je uključen u ćelijsku otpornost na stresove oštećenja DNK i može djelovati kao regulator obilja proteinskih kinaza, povezanih s fosfoinozitid-3-kinazom (PIKK).
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000129696 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031577 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: TELO2 interacting protein 2". Pristupljeno 14. 12. 2016.
- ^ "UniProt, Q6NXR4" (jezik: engleski). Pristupljeno 22. 9. 2021.
Dopunska literatura
- Hurov KE, Cotta-Ramusino C, Elledge SJ (2010). "A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability". Genes Dev. 24 (17): 1939–50. doi:10.1101/gad.1934210. PMC 2932975. PMID 20810650.
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Index:
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