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UBAC1

UBAC1

Dostupne strukture

Pretraga ortologa: PDBe RCSB

Spisak PDB ID kodova
2DAI

Identifikatori

Vanjski ID-jevi

OMIM: 608129 MGI: 1920995 HomoloGene: 9409 GeneCards: UBAC1

Lokacija gena (čovjek)

Hrom.	Hromosom 9 (čovjek)^[1]

Bend	9q34.3	Početak	135,932,969 bp^[1]
Bend	9q34.3	Kraj	135,961,373 bp^[1]

Lokacija gena (miš)

Hrom.	Hromosom 2 (miš)^[2]

Bend	2\|2 A3	Početak	25,888,555 bp^[2]
Bend	2\|2 A3	Kraj	25,911,759 bp^[2]

Obrazac RNK ekspresije

Više referentnih podataka o ekspresiji

Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine
Ćelijska komponenta	• ćelijska membrana • Golđijev aparat • Egzosom • citoplazma • citosol
Biološki proces	• protein ubiquitination
Izvori:Amigo / QuickGO

Vrste

Čovjek

Miš


10422


98766


ENSG00000130560


ENSMUSG00000036352


Q9BSL1


Q8VDI7

RefSeq (mRNK)


NM_016172


NM_133835 NM_001362681

RefSeq (bjelančevina)


NP_057256


NP_598596 NP_001349610

Lokacija (UCSC)

Chr 9: 135.93 – 135.96 Mb

Chr 2: 25.89 – 25.91 Mb

PubMed pretraga

^[3]

^[4]

Pogledaj/uredi – čovjek

Pogledaj/uredi – miš

Ubikvitinu pridruženi protein 1 sa domenom je protein koji je kod ljudi kodiran genom UBAC1.^[5]^[6]^[7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 405 aminokiselina, а molekulska težina 45.338 Da.^[8]

D: Asparaginska kiselina

E: Glutaminska kiselina

Y: Tirozin

10		20		30		40		50
MFVQEEKIFA		GKVLRLHICA		SDGAEWLEEA		TEDTSVEKLK		ERCLKHCAHG
SLEDPKSITH		HKLIHAASER		VLSDARTILE		ENIQDQDVLL		LIKKRAPSPL
PKMADVSAEE		KKKQDQKAPD		KEAILRATAN		LPSYNMDRAA		VQTNMRDFQT
ELRKILVSLI		EVAQKLLALN		PDAVELFKKA		NAMLDEDEDE		RVDEAALRQL
TEMGFPENRA		TKALQLNHMS		VPQAMEWLIE		HAEDPTIDTP		LPGQAPPEAE
GATAAASEAA		AGASATDEEA		RDELTEIFKK		IRRKREFRAD		ARAVISLMEM
GFDEKEVIDA		LRVNNNQQNA		ACEWLLGDRK		PSPEELDKGI		DPDSPLFQAI
LDNPVVQLGL		TNPKTLLAFE		DMLENPLNST		QWMNDPETGP		VMLQISRIFQ
TLNRT

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000130560 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036352 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Li C, Rodriguez M, Adamson JW, Banerjee D (Aug 2000). "Identification of a glialblastoma cell differentiation factor-related gene mRNA in human microvascular endothelial cells". Genomics. 65 (3): 243–52. doi:10.1006/geno.2000.6176. PMID 10857748.
^ Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
^ "Entrez Gene: UBADC1 ubiquitin associated domain containing 1".
^ "UniProt, Q9BSL1". Pristupljeno 12. 9. 2021.

Dopunska literatura

Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Tao Y, Kupfer R, Stewart BJ, et al. (2006). "AIRE recruits multiple transcriptional components to specific genomic regions through tethering to nuclear matrix". Mol. Immunol. 43 (4): 335–45. doi:10.1016/j.molimm.2005.02.018. PMID 16310047.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Kotoshiba S, Kamura T, Hara T, et al. (2005). "Molecular dissection of the interaction between p27 and Kip1 ubiquitylation-promoting complex, the ubiquitin ligase that regulates proteolysis of p27 in G1 phase". J. Biol. Chem. 280 (18): 17694–700. doi:10.1074/jbc.M500866200. PMID 15746103.
Kamura T, Hara T, Matsumoto M, et al. (2005). "Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase". Nat. Cell Biol. 6 (12): 1229–35. doi:10.1038/ncb1194. PMID 15531880. S2CID 12225217.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.

Vanjski linkovi

p r u PDB galerija
2dai: Solution Structure of the First UBA Domain in the Human Ubiquitin Associated Domain Containing 1 (UBADC1)

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