UTY
Histonska demetilaza UTY je enzim koji je kod ljudi kodiran genom UTY.[3][4][5]
Ovaj gen kodira protein koji sadrži tetratrikopeptid-ponavljanje za koji se smatra da je uključen u interakcije protein-protein. Manji je antigen histokompatibilnost, koji može inducirati odbacivanje transplantata presađenih muških matičnih ćelija. Alternativna prerada RNK rezultira u više varijanti transkripta koji kodiraju različite izoforme.[5]
Interakcije
Pokazano je da UTY ima interakcije sa TLE1 [6] i WDR90.[7]
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000183878 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Greenfield A, Scott D, Pennisi D, Ehrmann I, Ellis P, Cooper L, et al. (decembar 1996). "An H-YDb epitope is encoded by a novel mouse y chromosome gene". nature genetics. 14 (4): 474–8. doi:10.1038/ng1296-474. PMID 8944031.
- ^ Greenfield A, Carrel L, Pennisi D, Philippe C, Quaderi N, Siggers P, et al. (april 1998). "The UTX gene escapes X inactivation in mice and humans". Human Molecular Genetics. 7 (4): 737–42. doi:10.1093/hmg/7.4.737. PMID 9499428.
- ^ a b "Entrez Gene: UTY ubiquitously transcribed tetratricopeptide repeat gene, Y-linked".
- ^ Grbavec D, Lo R, Liu Y, Greenfield A, Stifani S (januar 1999). "Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms". The Biochemical Journal. 337 ( Pt 1) (1): 13–7. doi:10.1042/0264-6021:3370013. PMC 1219929. PMID 9854018.
- ^ "STRING: functional protein association networks". string-db.org. Arhivirano s originala, 15. 5. 2013. Pristupljeno 7. 5. 2015.
Dopunska literatura
- Lahn BT, Page DC (oktobar 1997). "Functional coherence of the human Y chromosome". Science. 278 (5338): 675–80. Bibcode:1997Sci...278..675L. doi:10.1126/science.278.5338.675. PMID 9381176.
- Grbavec D, Lo R, Liu Y, Greenfield A, Stifani S (januar 1999). "Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms". The Biochemical Journal. 337 ( Pt 1) (1): 13–7. doi:10.1042/0264-6021:3370013. PMC 1219929. PMID 9854018.
- Warren EH, Gavin MA, Simpson E, Chandler P, Page DC, Disteche C, et al. (mart 2000). "The human UTY gene encodes a novel HLA-B8-restricted H-Y antigen". Journal of Immunology. 164 (5): 2807–14. doi:10.4049/jimmunol.164.5.2807. PMID 10679124.
- Foresta C, Ferlin A, Moro E (maj 2000). "Deletion and expression analysis of AZFa genes on the human Y chromosome revealed a major role for DBY in male infertility". Human Molecular Genetics. 9 (8): 1161–9. doi:10.1093/hmg/9.8.1161. PMID 10767340.
- Shen P, Wang F, Underhill PA, Franco C, Yang WH, Roxas A, et al. (juni 2000). "Population genetic implications from sequence variation in four Y chromosome genes". Proceedings of the National Academy of Sciences of the United States of America. 97 (13): 7354–9. Bibcode:2000PNAS...97.7354S. doi:10.1073/pnas.97.13.7354. PMC 16549. PMID 10861003.
- Vogt MH, Goulmy E, Kloosterboer FM, Blokland E, de Paus RA, Willemze R, Falkenburg JH (novembar 2000). "UTY gene codes for an HLA-B60-restricted human male-specific minor histocompatibility antigen involved in stem cell graft rejection: characterization of the critical polymorphic amino acid residues for T-cell recognition". Blood. 96 (9): 3126–32. PMID 11049993.
- Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (maj 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
- Agate RJ, Choe M, Arnold AP (februar 2004). "Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches". Molecular Biology and Evolution. 21 (2): 384–96. doi:10.1093/molbev/msh027. PMID 14660691.
- Gerrard DT, Filatov DA (juni 2005). "Positive and negative selection on mammalian Y chromosomes". Molecular Biology and Evolution. 22 (6): 1423–32. doi:10.1093/molbev/msi128. PMID 15758204.
Content Disclaimer
Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.
- The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
- There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
- It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
- Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
- Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.
Index:
pl ar de en es fr it arz nl ja pt ceb sv uk vi war zh ru af ast az bg zh-min-nan bn be ca cs cy da et el eo eu fa gl ko hi hr id he ka la lv lt hu mk ms min no nn ce uz kk ro simple sk sl sr sh fi ta tt th tg azb tr ur zh-yue hy my ace als am an hyw ban bjn map-bms ba be-tarask bcl bpy bar bs br cv nv eml hif fo fy ga gd gu hak ha hsb io ig ilo ia ie os is jv kn ht ku ckb ky mrj lb lij li lmo mai mg ml zh-classical mr xmf mzn cdo mn nap new ne frr oc mhr or as pa pnb ps pms nds crh qu sa sah sco sq scn si sd szl su sw tl shn te bug vec vo wa wuu yi yo diq bat-smg zu lad kbd ang smn ab roa-rup frp arc gn av ay bh bi bo bxr cbk-zam co za dag ary se pdc dv dsb myv ext fur gv gag inh ki glk gan guw xal haw rw kbp pam csb kw km kv koi kg gom ks gcr lo lbe ltg lez nia ln jbo lg mt mi tw mwl mdf mnw nqo fj nah na nds-nl nrm nov om pi pag pap pfl pcd krc kaa ksh rm rue sm sat sc trv stq nso sn cu so srn kab roa-tara tet tpi to chr tum tk tyv udm ug vep fiu-vro vls wo xh zea ty ak bm ch ny ee ff got iu ik kl mad cr pih ami pwn pnt dz rmy rn sg st tn ss ti din chy ts kcg ve
