ZNF83
Protein 83 cinkovog prsta je protein koji je kod ljudi kodiran genom ZNF83.[3][4]
- Aminokiselinska sekvenca
- Simboli
C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MHGRKDDAQK | QPVKNQLGLN | PQSHLPELQL | FQAEGKIYKY | DHMEKSVNSS | ||||
| SLVSPPQRIS | STVKTHISHT | YECNFVDSLF | TQKEKANIGT | EHYKCSERGK | ||||
| AFHQGLHFTI | HQIIHTKETQ | FKCDICGKIF | NKKSNLASHQ | RIHTGEKPYK | ||||
| CNECGKVFHN | MSHLAQHRRI | HTGEKPYKCN | ECGKVFNQIS | HLAQHQRIHT | ||||
| GEKPYKCNEC | GKVFHQISHL | AQHRTIHTGE | KPYECNKCGK | VFSRNSYLVQ | ||||
| HLIIHTGEKP | YRCNVCGKVF | HHISHLAQHQ | RIHTGEKPYK | CNECGKVFSH | ||||
| KSSLVNHWRI | HTGEKPYKCN | ECGKVFSHKS | SLVNHWRIHT | GEKPYKCNEC | ||||
| GKVFSRNSYL | AQHLIIHAGE | KPYKCDECDK | AFSQNSHLVQ | HHRIHTGEKP | ||||
| YKCDECGKVF | SQNSYLAYHW | RIHTGEKAYK | CNECGKVFGL | NSSLAHHRKI | ||||
| HTGEKPFKCN | ECGKAFSMRS | SLTNHHAIHT | GEKHFKCNEC | GKLFRDNSYL | ||||
| VRHQRFHAGK | KSNTCN |
Interakcije
Pokazalo se da proteini cinkovog prsta ulaze u interakciju s nukleinskim kiselinama i imaju različite funkcije. Domen cinkovog prsta je konzervirani motiv aminokiselinske sekvence koji sadrži po dva posebno postavljena cisteina i histidina, koji su uključeni u koordinaciju cinka. Proteini povezani sa Kruppelom čine jednu porodicu proteina cinkovih prstiju.[4]
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000167766 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Marine JC, Bellefroid EJ, Bourguignon C, Riviere M, Lecoq PJ, Poncelet DA, Szpirer J, Martial JA, Szpirer C (Oct 1994). "Assignment of the human ZNF83 (HPF1) zinc finger gene to chromosome 19q13.3-q13.4". Genomics. 21 (1): 285–6. doi:10.1006/geno.1994.1262. PMID 8088807.
- ^ a b "Entrez Gene: ZNF83 zinc finger protein 83".
Dopunska literatura
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Abrink M, Aveskogh M, Hellman L (1995). "Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937". DNA Cell Biol. 14 (2): 125–36. doi:10.1089/dna.1995.14.125. PMID 7865130.
- Bellefroid EJ, Lecocq PJ, Benhida A, et al. (1989). "The human genome contains hundreds of genes coding for finger proteins of the Krüppel type". DNA. 8 (6): 377–87. doi:10.1089/dna.1.1989.8.377. PMID 2505992.
Vanjski linkovi
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